DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lok and drl

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001260566.1	Gene:	drl / 44355	FlyBaseID:	FBgn0015380	Length:	645	Species:	Drosophila melanogaster

Alignment Length:	365	Identity:	74/365 - (20%)
Similarity:	140/365 - (38%)	Gaps:	105/365 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   131 TNRMRILKNDD------VISLSH-----------PTYKAFV--FKDLSPNESIGLPEEINKTYY- 175
            :|.:.::|...      :.|.:|           |||....  |::....     |||.|:...
  Fly   276 SNGVHLIKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPFREYEHE-----PEEFNRRLQE 335

  Fly   176 ---------VNRKLGSGAYG-LVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAK 230
                     ::..:..|.:| :.|..|:  .||:..:|.|.::   .::...|.     :|.|:.
  Fly   336 LTVQKCRVRLSCLVQEGNFGRIYRGTYN--DCQEVLVKTVAQH---ASQLQVNL-----LLQESM 390

  Fly   231 IMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDIS----------KLYFY 285
            ::...|||.|:.:..|..:..:...|| :...|.:.|.    |...:|.|          .|...
  Fly   391 MLYEASHPNVLSVLGISIEDYATPFVL-YAATGSVRNL----KSFLQDPSYARSVTTIQTVLMGS 450

  Fly   286 QMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFV-------QKDSVMRTLCGT 343
            |:..|:::||:.|:.|:|:...|.::   |::..:|::|..||:.:       ..|...|.:
  Fly   451 QLAMAMEHLHNHGVIHKDIAARNCVI---DDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPI--- 509

  Fly   344 PLYVAPEVLITGGREAYTKKVDIWSLGVVLF-TCLSGTLPFSDEYGTPAAQQIKKG-RFA--YGH 404
             .:::.|.|   .:..|.:..|:||.||::: .|..|.||:::.........:|.| |.|  :..
  Fly   510 -KWLSLEAL---QKSHYNEGSDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNC 570

  Fly   405 PS---------WKSVSQRAKLLINQMLIVDPERRPSIDDV 435
            |.         |.|:               |..|||...:
  Fly   571 PDELFTIMAYCWASM---------------PAERPSFSQL 595

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	7/43 (16%)
		STKc_Chk2	167..441	CDD:270986	66/310 (21%)
		S_TKc	174..441	CDD:214567	62/303 (20%)
drl	NP_001260566.1	WIF	21..157	CDD:128745
		PTK_Ryk	336..606	CDD:270639	62/300 (21%)
		Pkinase_Tyr	343..599	CDD:285015	62/293 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910