DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lok and PKD

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001262705.1	Gene:	PKD / 42203	FlyBaseID:	FBgn0038603	Length:	906	Species:	Drosophila melanogaster

Alignment Length:	486	Identity:	132/486 - (27%)
Similarity:	231/486 - (47%)	Gaps:	69/486 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ARDTQGTQGTQSQASNIWTQVESQPMEKIVWGRLYGKN-----------IKIKSLGTSSKYRIIY 55
            ::.:...|..|||:|...:...:.|:.:||....:.|.           :...||..:.| |..:
  Fly   361 SKSSSDGQSEQSQSSTSSSPSANIPLMRIVQSVKHTKKRGGQALKEGWLVHYTSLDKAVK-RYYW 424

  Fly    56 THSSFSVDLNNDEFTAGRGEANDLILTLNDLPEKILTRISKVHFIIKRANCELTNPVYIQDLSRN 120
            ...|.::.|    |.:.:|....     .:||...|..|.. |....|..|.....:.:.:||
  Fly   425 RLDSKTITL----FVSEQGSKYH-----KELPLAELLSIES-HLGDPRPECNYCFELRLPNLS-- 477

  Fly   121 GTFVNNE-KIGTNRMRILKNDDVISLSHPTYKAFVFKDLSPN------------------ESIGL 166
             .||..: ::|.      |.:..:.|..|  .:.:..|::.:                  ||...
  Fly   478 -YFVGQDPQVGA------KEEQAVRLPPP--DSGIGSDIAKSWETSIRQAFMHVTNTQCCESEEQ 533

  Fly   167 PEEINKTYYV--NRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEA 229
            .:::.:.|.:  :..||||.:|:|......:|.::.|:|::.|......:.:       ::.||.
  Fly   534 VQDMGQLYQIFPDEVLGSGQFGVVYGGVHKKTQREVAIKVIDKLRFPTKQEA-------QLKNEV 591

  Fly   230 KIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNK--LLSEDISKLYFYQMCHAVK 292
            .|::|:||..||.:..:.:.|:.:::|:|.:: ||:|..|:|:.  .|||.::|....|:..|:|
  Fly   592 AILQNISHCGVVNLERMFETPERIFVVMEKLK-GDMLEMILSHARGRLSERVTKFLITQILIALK 655

  Fly   293 YLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGR 357
            |||.:.|.|.||||:||||.::.|...:|:.|||.::.:.:.|..|::.|||.|:|||||...|
  Fly   656 YLHSQNIVHCDLKPENVLLSSDAEFPQVKLCDFGYARIIGEKSFRRSVVGTPAYLAPEVLRNKG- 719

  Fly   358 EAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQML 422
              |.:.:|:||:||:::..||||.||::|  .....||:...|.|....||.:|..|..|||.:|
  Fly   720 --YNRSLDMWSVGVIIYVSLSGTFPFNEE--EDINDQIQNAAFMYPPNPWKEISSNAIDLINNLL 780

  Fly   423 IVDPERRPSIDDVLQSSWLRDAPMLQKAKRL 453
            .|...:|.::|..|...||:|....:..:.|
  Fly   781 QVKQRKRYTVDKSLLHYWLQDKQTYRDLRNL 811

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	23/128 (18%)
		STKc_Chk2	167..441	CDD:270986	93/277 (34%)
		S_TKc	174..441	CDD:214567	93/270 (34%)
PKD	NP_001262705.1	C1_1	109..154	CDD:278556
		C1	223..272	CDD:197519
		PH_PKD	396..522	CDD:269945	25/147 (17%)
		STKc_PKD	539..798	CDD:270984	93/271 (34%)
		S_TKc	547..799	CDD:214567	92/264 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910