DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and Aduk

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_731331.1	Gene:	Aduk / 41112	FlyBaseID:	FBgn0037679	Length:	520	Species:	Drosophila melanogaster

Alignment Length:	303	Identity:	89/303 - (29%)
Similarity:	150/303 - (49%)	Gaps:	22/303 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 YYVNRKLGSGAYGLVRLVYDTRTCQQ---FAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNL 235
            :.:..|||:|:|.   .||..|..:|   .|:|.|:.:.||.       :..:.::.|.::::.|
  Fly     9 FEILEKLGAGSYA---TVYKARHKKQRTYHAIKYVEMSTLSQ-------TSRENLITEIRLLREL 63

  Fly   236 SHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGIT 300
            .|..:|.:.|......::|:|||:...|:|...|.:.|.|.|...:.:..|:..||:|:....::
  Fly    64 KHKYIVTLQDFFWDDKNIYIVLEYCNAGNLSAFIRTKKALPESTCRYFLRQLAAAVQYMRANDVS 128

  Fly   301 HRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTKKVD 365
            |.||||.|:||........|||:|||.::.::...:.:.|.|:|||:|||::   .:..|..|.|
  Fly   129 HFDLKPQNLLLTRGANNVSLKVADFGFAQHLKLGEINQQLKGSPLYMAPEIV---RKHQYDAKAD 190

  Fly   366 IWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRP 430
            :||:||:|:.||.|..|:|.........:|:|.. |...|....:|.....|:.::|..:|..|.
  Fly   191 LWSIGVILYECLFGKAPYSSRTIEELLLRIRKAE-AITLPPNARISNECHDLLRRLLAHEPTARI 254

  Fly   431 SIDDVLQSSW--LRDAP---MLQKAKRLMKLDGMEIEEENFLE 468
            |..|.....:  |:..|   .||||..|:.......|:.|:.|
  Fly   255 SFADFFAHPFLDLKTFPTEHTLQKAIDLVTQACAYDEKHNYKE 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	79/271 (29%)
		S_TKc	174..441	CDD:214567	79/271 (29%)
Aduk	NP_731331.1	S_TKc	9..265	CDD:214567	79/269 (29%)
		PKc_like	13..264	CDD:304357	79/264 (30%)
		MIT_2	274..348	CDD:239147	8/24 (33%)
		MIT	407..472	CDD:282117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910