DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and phkg2

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_957256.1	Gene:	phkg2 / 393937	ZFINID:	ZDB-GENE-040426-825	Length:	390	Species:	Danio rerio

Alignment Length:	281	Identity:	94/281 - (33%)
Similarity:	148/281 - (52%)	Gaps:	24/281 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 EEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVK-------KNMLSGARPSTNFSDPDRV 225
            :|..:.|.....:|.|...:||......|.|:||:||::       :..|...:.||
Zfish    18 KEFYQKYDPKEVIGRGVSSVVRRCVHKHTGQEFAVKIIEITAEKMTEQQLEEVKSST-------- 74

  Fly   226 LNEAKIMKNL--SHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMC 288
            |.|..:: ||  .||.::.:.|..:....:::|.:.||.|:|.:.:.....|||..::.....:.
Zfish    75 LKEIHVL-NLVKGHPSIITLIDSYESTAFIFLVFDLMRRGELFDYLTEKVTLSEKETRSMMRALL 138

  Fly   289 HAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVL- 352
            .||:|||...|.||||||:|:||   |::..||:||||.|..:..|..:|.|||||.|:|||:|
Zfish   139 EAVQYLHALNIVHRDLKPENILL---DDQGHLKLSDFGFSVQLGPDEKLRELCGTPGYLAPEILK 200

  Fly   353 --ITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAK 415
              :....|.|.|:||:|:.||:|||.|:|:.||.........:.|.:||:.:..|.|...|...|
Zfish   201 CSMDETHEGYGKEVDLWACGVILFTLLAGSPPFWHRKQLLMLRMIMEGRYQFSSPEWDDRSDTVK 265

  Fly   416 LLINQMLIVDPERRPSIDDVL 436
            .||:::|:|:|..|.:.:..|
Zfish   266 DLISRLLVVEPTIRLTAEQAL 286

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	94/281 (33%)
		S_TKc	174..441	CDD:214567	93/275 (34%)
phkg2	NP_957256.1	STKc_PhKG2	13..291	CDD:271083	94/281 (33%)
phkg2	NP_957256.1	Pkinase	24..291	CDD:278497	93/275 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910