DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and 4921509C19Rik

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_941057.1	Gene:	4921509C19Rik / 381393	MGIID:	2685851	Length:	640	Species:	Mus musculus

Alignment Length:	292	Identity:	98/292 - (33%)
Similarity:	154/292 - (52%)	Gaps:	32/292 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   156 KDLSPN--ESIGLPEEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIV---KKNMLSGARP 215
            :||..|  |...|.|.    |.:...||.|.:|.|:|.....|..:.|:||:   :||.|
Mouse     8 QDLRSNTFEDAALTEH----YEILTTLGQGTFGEVKLASHLVTQTKVAIKILPKSRKNSL----- 63

  Fly   216 STNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDIS 280
                     |..|.:|||:|.||.::::..|:|...::::|||...||:|::||.....|:|...
Mouse    64 ---------VQPEIEIMKSLDHPHIIKLLHIIDTTRNIFIVLEHAVGGELMSRIEEFGYLAEVEC 119

  Fly   281 KLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPL 345
            ...|.|:.:|::|.|::||.||||||:|:||   |....:|::||||...:.....:.|.|||..
Mouse   120 HRLFKQLVYALQYCHEKGIVHRDLKPENILL---DHRGNVKLTDFGLGTKIIMGQKLVTFCGTLP 181

  Fly   346 YVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSV 410
            |.|||:....|.:.  :..|:|||||||:...:|.|||:........|:|..|::    |...|:
Mouse   182 YCAPELFEDRGYDG--RATDVWSLGVVLYFMATGCLPFNGYSYEAIKQKIIAGKY----PRSFSL 240

  Fly   411 SQRAKLLINQMLIVDPERRPSIDDVLQSSWLR 442
            |.....:|.::|.|:|..||::.|:.:..||:
Mouse   241 SPELWEVIAKLLTVNPGERPTVHDIARFKWLK 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	98/292 (34%)
		STKc_Chk2	167..441	CDD:270986	91/276 (33%)
		S_TKc	174..441	CDD:214567	90/269 (33%)
4921509C19Rik	NP_941057.1	STKc_AMPK-like	23..270	CDD:270905	90/273 (33%)
		UBA_MARK_Par1	290..328	CDD:270522
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	359..399
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	464..509
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..576
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	617..640
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910