DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and Gm14147

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001365536.1	Gene:	Gm14147 / 381390	MGIID:	3651555	Length:	640	Species:	Mus musculus

Alignment Length:	294	Identity:	100/294 - (34%)
Similarity:	155/294 - (52%)	Gaps:	32/294 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   154 VFKDLSPN--ESIGLPEEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIV---KKNMLSGA 213
            |.:||..|  |...|.|.    |.:...||.|.:|.|:|.....|..:.|:||:   :||.|
Mouse     6 VCQDLRSNTFEEAALTEH----YEILTTLGQGTFGDVKLANHLVTQTKVAIKILPQNRKNPL--- 63

  Fly   214 RPSTNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSED 278
                       |..|.:|||:|.||.::::..|:|...::::|||...||:|:|||.....|:|.
Mouse    64 -----------VQPEIEIMKSLDHPHIIKLLHIIDTTRNIFIVLEHAVGGELMNRIEEFGYLAEV 117

  Fly   279 ISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGT 343
            .....|.|:.:|::|.|::||.||||||:|:||   |....:|::||||...:.....:.|.|||
Mouse   118 ECHRLFKQLVYALQYCHEKGIVHRDLKPENILL---DHRGNVKLTDFGLGTKIIMGQKLVTFCGT 179

  Fly   344 PLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWK 408
            ..|.|||:....|.:.  :..|:|||||||:...:|.|||:........|:|..|::    |...
Mouse   180 LPYCAPELFEDRGYDG--RATDVWSLGVVLYFMATGCLPFNGYSYEAIKQKIIAGKY----PRSF 238

  Fly   409 SVSQRAKLLINQMLIVDPERRPSIDDVLQSSWLR 442
            |:|.....:|.::|.|:|..||::.|:.:..||:
Mouse   239 SLSPELWEVIAKLLTVNPGERPTVHDIARFKWLK 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	1/1 (100%)
		STKc_Chk2	167..441	CDD:270986	92/276 (33%)
		S_TKc	174..441	CDD:214567	91/269 (34%)
Gm14147	NP_001365536.1	STKc_AMPK-like	23..270	CDD:270905	91/273 (33%)
Gm14147	NP_001365536.1	UBA_MARK_Par1	290..328	CDD:270522
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910