DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lok and RGD1565071

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_017450658.1	Gene:	RGD1565071 / 368175	RGDID:	1565071	Length:	493	Species:	Rattus norvegicus

Alignment Length:	318	Identity:	94/318 - (29%)
Similarity:	167/318 - (52%)	Gaps:	34/318 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 SPNESIGLPEEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVK--KNMLSGARPSTNFSD 221
            :||:     :.:...|.:...||.|::|.|:|.:..:|....|:|.|:  |..:.|
  Rat     4 NPNK-----KTLRSQYRMAFLLGQGSFGNVKLAWHRKTQALVAIKSVEICKKTIRG--------- 54

  Fly   222 PDRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQ 286
               :|:|..|:::|.||.::.:..::.....::.:|:::.||:|:..|.....|.|:.:|..|.|
  Rat    55 ---ILSEMTILESLHHPNIISLFQVLLTSSQIHFILQYVPGGNLVELIREEGPLPEEQAKKMFGQ 116

  Fly   287 MCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEV 351
            :..|::|.|.|||.|||:||.|:|:   |....:|:.|||::...:..::::|.|||..:.|||:
  Rat   117 VVSALRYCHSRGIVHRDIKPQNILI---DAAGNVKLIDFGVAIKCRPGTLLKTQCGTRGFCAPEI 178

  Fly   352 LITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKL 416
            ::  |.....||.|:|||||:||...:|..||.........|::..|  .|..|:  .:|.:.:.
  Rat   179 VL--GEPYDGKKADVWSLGVLLFFLTTGYFPFRGGTTDQIKQKVTTG--TYTIPT--HLSGQLEN 237

  Fly   417 LINQMLIVDPERRPSIDDVLQSSWLRDA-----PMLQKAKRLMK-LDGMEIEEENFLE 468
            ||:|:|.|.||.||||:::....|::..     ||.....:::: |.||.....:.||
  Rat   238 LIHQILTVSPELRPSIEEIENHPWIKKCEVNIPPMTDPDYKIIEMLCGMGYNANDILE 295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	84/275 (31%)
		S_TKc	174..441	CDD:214567	84/268 (31%)
RGD1565071	XP_017450658.1	STKc_AMPK-like	13..261	CDD:270905	84/268 (31%)
RGD1565071	XP_017450658.1	UBA_MARK_Par1	275..312	CDD:270522	5/21 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910