DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and CG17528

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001036462.1	Gene:	CG17528 / 3355134	FlyBaseID:	FBgn0261387	Length:	748	Species:	Drosophila melanogaster

Alignment Length:	279	Identity:	94/279 - (33%)
Similarity:	155/279 - (55%)	Gaps:	17/279 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   166 LPEEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAK 230
            ||..|..||.:.|.:|.|.:.:|..:...:|...:|:||:.||...|   ..::.|.     |.:
  Fly   469 LPSNIRNTYSLGRIIGDGNFAIVFKIKHRQTGHSYALKIIDKNKCKG---KEHYIDA-----EVR 525

  Fly   231 IMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLH 295
            :||.|:||.::.:...||:..::|:|||::.||||.:.|......||:.|::....:..|:.|||
  Fly   526 VMKKLNHPHIISLILSVDQNTNMYLVLEYVSGGDLFDAITQVTRFSENQSRIMIRHLGAAMTYLH 590

  Fly   296 DRGITHRDLKPDNVLLETNDEETL--LKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGRE 358
            ..||.|||:||:|:|::.::...:  ||::||||:  .:.:.::..:||||.|||||:|:..|
  Fly   591 SMGIVHRDIKPENLLVKLDEHGNVLELKLADFGLA--CEVNDLLYAVCGTPTYVAPEILLEVG-- 651

  Fly   359 AYTKKVDIWSLGVVLFTCLSGTLPF--SDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQM 421
             |..|:|:|:.|::|:..|.|..||  .|....|....|..|.:.:..|.|..:....:.||..|
  Fly   652 -YGLKIDVWAAGIILYILLCGFPPFVAPDNQQEPLFDAIISGIYEFPDPYWSDIGDGVRDLIANM 715

  Fly   422 LIVDPERRPSIDDVLQSSW 440
            |..||:.|.:.:|:|..||
  Fly   716 LQADPDVRFTSEDILDHSW 734

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	93/278 (33%)
		S_TKc	174..441	CDD:214567	90/271 (33%)
CG17528	NP_001036462.1	DCX	153..244	CDD:214711
		DCX	308..396	CDD:214711
		PKc_like	477..734	CDD:304357	88/269 (33%)
		S_TKc	477..734	CDD:214567	88/269 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910