DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and PhKgamma

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_511129.3	Gene:	PhKgamma / 32120	FlyBaseID:	FBgn0011754	Length:	560	Species:	Drosophila melanogaster

Alignment Length:	293	Identity:	94/293 - (32%)
Similarity:	158/293 - (53%)	Gaps:	25/293 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 DLSPNESIGLPEEINKTYYVNRK----LGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPST 217
            ||.|:      ::..|.:|...:    ||.|....||...:..|.::||.||:.    .||...:
  Fly     8 DLLPD------KDAAKGFYAKYEPKEILGRGISSTVRRCIEKETGKEFAAKIID----LGATTES 62

  Fly   218 NFSDPDRVL----NEAKIMKN-LSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSE 277
            ..::|..:|    .|..|::. :.||.::.:.|:.:....|::|.|....|:|.:.:.|...|||
  Fly    63 GETNPYHMLEATRQEISILRQVMGHPYIIDLQDVFESDAFVFLVFELCPKGELFDYLTSVVTLSE 127

  Fly   278 DISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCG 342
            ..::....|:...|:|:|.:.|.||||||:|:||   ||...:|::|||.:|.:|:...:..|||
  Fly   128 KKTRTIMRQIFEGVEYIHAKSIVHRDLKPENILL---DENHNVKITDFGFAKQLQEGEKLTNLCG 189

  Fly   343 TPLYVAPEVL---ITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGH 404
            ||.|:|||.|   :..|...|:::||||:.||::||.|.|..||.........:.|.:|::::..
  Fly   190 TPGYLAPETLKCNMFEGSPGYSQEVDIWACGVIMFTLLVGCPPFWHRKQMVMLRNIMEGKYSFTS 254

  Fly   405 PSWKSVSQRAKLLINQMLIVDPERRPSIDDVLQ 437
            |.|..:|:..|.||.:.|:|||.:|.::.:||:
  Fly   255 PEWADISEDPKDLIRKCLVVDPSQRITVKEVLR 287

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	91/283 (32%)
		S_TKc	174..441	CDD:214567	90/276 (33%)
PhKgamma	NP_511129.3	STKc_PhKG	19..291	CDD:270995	90/276 (33%)
PhKgamma	NP_511129.3	S_TKc	23..291	CDD:214567	89/272 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR44167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010