DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and Dclk3

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001178729.1	Gene:	Dclk3 / 316023	RGDID:	1309232	Length:	807	Species:	Rattus norvegicus

Alignment Length:	280	Identity:	99/280 - (35%)
Similarity:	166/280 - (59%)	Gaps:	24/280 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 EINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMK 233
            ::.|.|.:.|.:|.|.:.:|:......|.|.:||||:.|:.|.|..        |.|.:|..|::
  Rat   510 DVEKHYDIGRVIGDGNFAIVKECKHRETRQAYAMKIIDKSQLKGKE--------DIVDSEILIIQ 566

  Fly   234 NLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRG 298
            :||||.:|::|::.:....:|:::|:::||||.:.||.:....|..:.:....:|.|:.::||:.
  Rat   567 SLSHPNIVKLHEVYETEAEIYLIMEYVQGGDLFDAIIESVKFPEPDAAVMITDLCKALVHMHDKK 631

  Fly   299 ITHRDLKPDNVLLETN-DEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTK 362
            |.||||||:|:|::.| |:.|.||::||||:|.|.:.  :.|:||||.|||||:|   ..:.|..
  Rat   632 IVHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRP--IFTVCGTPTYVAPEIL---SEKGYGL 691

  Fly   363 KVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQ------IKKGRFAYGHPSWKSVSQRAKLLINQM 421
            :||:|:.||:|:..|.|..||.    :|...|      |:.|:|.:..|.|.::|..||.|:..:
  Rat   692 EVDMWAAGVILYILLCGFPPFR----SPERDQDELFNIIQLGQFEFLSPYWDNISDAAKDLVRNL 752

  Fly   422 LIVDPERRPSIDDVLQSSWL 441
            |:|||::|.:...||...|:
  Rat   753 LVVDPKKRYTAHQVLHHPWI 772

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	98/278 (35%)
		S_TKc	174..441	CDD:214567	97/273 (36%)
Dclk3	NP_001178729.1	UBQ	92..177	CDD:294102
		PKc_like	514..771	CDD:304357	97/273 (36%)
		S_TKc	515..772	CDD:214567	97/273 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101842
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810