DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and Mapkapk2

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_835203.1	Gene:	Mapkapk2 / 289014	RGDID:	631362	Length:	386	Species:	Rattus norvegicus

Alignment Length:	316	Identity:	96/316 - (30%)
Similarity:	164/316 - (51%)	Gaps:	40/316 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   170 INKTYYV-NRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMK 233
            |...|.| ::.||.|..|.|..::|.||.|:||:|:::              |..:...|.::..
  Rat    45 ITDDYKVTSQVLGLGINGKVLRIFDKRTQQKFALKMLQ--------------DCPKARREVELHW 95

  Fly   234 NLSHPCVVRMHDIVDKPDSVY-------MVLEFMRGGDLLNRI--ISNKLLSEDISKLYFYQMCH 289
            ..|. |...:| |||..:::|       :|:|.:.||:|.:||  ..::..:|..:......:..
  Rat    96 RASQ-CPHIVH-IVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGE 158

  Fly   290 AVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLIT 354
            |::|||...|.|||:||:|:|..:.....:||::|||.:|.....:.:.|.|.||.|||||||
  Rat   159 AIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVL-- 221

  Fly   355 GGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYG---TPAAQ-QIKKGRFAYGHPSWKSVSQRAK 415
             |.|.|.|..|:|||||:::..|.|..||...:|   :|..: :|:.|::.:.:|.|..||:..|
  Rat   222 -GPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVK 285

  Fly   416 LLINQMLIVDPERRPSIDDVLQSSWLRDAPMLQK----AKRLMKLD---GMEIEEE 464
            :||..:|..:|.:|.:|.:.:...|:..:..:.:    ..|::|.|   ..:::||
  Rat   286 MLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEE 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	90/284 (32%)
		S_TKc	174..441	CDD:214567	89/280 (32%)
Mapkapk2	NP_835203.1	STKc_MAPKAPK2	47..349	CDD:271072	95/314 (30%)
Mapkapk2	NP_835203.1	S_TKc	54..311	CDD:214567	87/275 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910