DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and Nek8

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001099274.1	Gene:	Nek8 / 287473	RGDID:	1306897	Length:	698	Species:	Rattus norvegicus

Alignment Length:	264	Identity:	81/264 - (30%)
Similarity:	135/264 - (51%)	Gaps:	23/264 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 RKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDR--VLNEAKIMKNLSHPCV 240
            |.:|.||:|:|.|      |.:   |..:|.::....|....:..:|  ..||.:::|.|:||.|
  Rat     8 RVVGRGAFGIVHL------CLR---KADQKLVIIKQIPVEQMTKEERQAAQNECQVLKLLNHPNV 63

  Fly   241 VRMHDIVDKPDSVYMVLEFMRGGDLLNRIIS--NKLLSEDISKLYFYQMCHAVKYLHDRGITHRD 303
            :..::...:..::.:.:|:..||.|...|..  |.||.|:....:|.|:..|:.::|...|.|||
  Rat    64 IEYYENFLEDKALMIAMEYAPGGTLAEFIQKRCNSLLEEETILHFFVQILLALHHVHTHLILHRD 128

  Fly   304 LKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTKKVDIWS 368
            ||..|:||:.:  ..::|:.|||:||.:...|...|:.|||.|::|| |..|  :.|.:|.|||:
  Rat   129 LKTQNILLDKH--RMVVKIGDFGISKILSSKSKAYTVVGTPCYISPE-LCEG--KPYNQKSDIWA 188

  Fly   369 LGVVLFTCLSGTLPFSDEYGTPA-AQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSI 432
            ||.||:...|....| :....|| ..:|..|.||   |.....|...:.|:..:|.::|.:||.:
  Rat   189 LGCVLYELASLKRAF-EAANLPALVLKIMSGTFA---PISDRYSPELRQLVLSLLSLEPAQRPPL 249

  Fly   433 DDVL 436
            ..::
  Rat   250 SHIM 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	81/264 (31%)
		S_TKc	174..441	CDD:214567	81/264 (31%)
Nek8	NP_001099274.1	STKc_Nek8	3..258	CDD:270859	81/264 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	281..307
		ATS1	318..663	CDD:227511
		RCC1 1	415..466
		RCC1 2	467..518
		RCC1 3	520..571
		RCC1 4	585..636
		RCC1 5	638..689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910