DRSC/TRiP Functional Genomics Resources

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Protein Alignment lok and EPHA6

DIOPT Version :9

Sequence 1:NP_477219.1 Gene:lok / 35288 FlyBaseID:FBgn0019686 Length:476 Species:Drosophila melanogaster
Sequence 2:XP_006713655.1 Gene:EPHA6 / 285220 HGNCID:19296 Length:1146 Species:Homo sapiens


Alignment Length:517 Identity:111/517 - (21%)
Similarity:184/517 - (35%) Gaps:157/517 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 ASNIWTQVESQPMEKIVWGRLYGK--NIKIKSLGTSSKYRI---IYTHSSFSVDLNNDEFTAGRG 74
            |...|..:..:..|::.:.....|  ::.|..|..::||..   :.|.:.:|......||..| .
Human   583 APAFWHYLRVEEHEQLTYSSTRSKAPSVIITGLKPATKYVFHIRVRTATGYSGYSQKFEFETG-D 646

  Fly    75 EANDL----------------------ILTLNDLPEKILTRISKVHFIIKRANCELTNPVYIQDL 117
            |.:|:                      ||||               |.:....|:.    ||:  
Human   647 ETSDMAAEQGQILVIATAAVGGFTLLVILTL---------------FFLITGRCQW----YIK-- 690

  Fly   118 SRNGTFVNNEKIGTNRMRILKNDDVISLSHPTYKAFVFKDLSPNESIGLPE---EINKT-YYVNR 178
               ....:.||    |...|:|.   .|..|..|.::..|...:.|:.:.|   ||:.: ..:.|
Human   691 ---AKMKSEEK----RRNHLQNG---HLRFPGIKTYIDPDTYEDPSLAVHEFAKEIDPSRIRIER 745

  Fly   179 KLGSGAYGLV---RLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHPCV 240
            .:|:|.:|.|   ||....:.....|:|.:|...:.  |...:|      |.||.||....||.:
Human   746 VIGAGEFGEVCSGRLKTPGKREIPVAIKTLKGGHMD--RQRRDF------LREASIMGQFDHPNI 802

  Fly   241 VRMHDIVDKPD------------------------------------------SVYMVLEFMRGG 263
            :|:..:|.|..                                          .|.:|:|:|..|
Human   803 IRLEGVVTKRSFPAIGVEAFCPSFLRAGFLNSIQAPHPVPGGGSLPPRIPAGRPVMIVVEYMENG 867

  Fly   264 DLLNRIISNKLLSEDISKLYFYQM-------CHAVKYLHDRGITHRDLKPDNVLLETNDEETLLK 321
            .|      :..|.:........|:       ...:|||.|.|..||||...|:|:.:|   .:.|
Human   868 SL------DSFLRKHDGHFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSN---LVCK 923

  Fly   322 VSDFGLSKFVQKD-SVMRTLCGTPL---YVAPEVLITGGREAYTK---KVDIWSLGVVLFTCLS- 378
            |||||||:.::.| ....|..|..:   :.|||.:      ||.|   ..|.||.|:|::..:| 
Human   924 VSDFGLSRVLEDDPEAAYTTTGGKIPIRWTAPEAI------AYRKFSSASDAWSYGIVMWEVMSY 982

  Fly   379 GTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLI----VDPERRPSIDDVL 436
            |..|:.:.........|::|   |..|:    .......::|:::    .:...||...|::
Human   983 GERPYWEMSNQDVILSIEEG---YRLPA----PMGCPASLHQLMLHCWQKERNHRPKFTDIV 1037

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lokNP_477219.1 FHA 39..156 CDD:238017 27/141 (19%)
STKc_Chk2 167..441 CDD:270986 78/338 (23%)
S_TKc 174..441 CDD:214567 75/327 (23%)
EPHA6XP_006713655.1 EphR_LBD_A6 128..300 CDD:198452
fn3 427..521 CDD:278470
FN3 537..644 CDD:238020 12/60 (20%)
EphA2_TM 664..736 CDD:291255 19/102 (19%)
PTKc_EphR_A 736..1044 CDD:270651 76/332 (23%)
Pkinase_Tyr 741..1040 CDD:285015 75/327 (23%)
SAM 1068..1135 CDD:197735
SAM_EPH-A6 1071..1134 CDD:188946
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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