DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and ssp2

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_588376.1	Gene:	ssp2 / 2539109	PomBaseID:	SPCC74.03c	Length:	576	Species:	Schizosaccharomyces pombe

Alignment Length:	279	Identity:	95/279 - (34%)
Similarity:	159/279 - (56%)	Gaps:	22/279 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 PEEINK----TYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPD-RVL 226
            ||.|:|    .|.:...||.|::|.|:|....:|.|:.|:|.:.:.:|..       ||.. ||.
pombe    23 PEAISKRHIGPYIIRETLGEGSFGKVKLATHYKTQQKVALKFISRQLLKK-------SDMHMRVE 80

  Fly   227 NEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAV 291
            .|...:|.|.||.:::::|::..|..:.||:|: .||:|.:.|:..|.::||..:.:|.|:..|:
pombe    81 REISYLKLLRHPHIIKLYDVITTPTDIVMVIEY-AGGELFDYIVEKKRMTEDEGRRFFQQIICAI 144

  Fly   292 KYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGG 356
            :|.|...|.||||||:|:||   |:...:|::|||||..:...:.::|.||:|.|.||||:  .|
pombe   145 EYCHRHKIVHRDLKPENLLL---DDNLNVKIADFGLSNIMTDGNFLKTSCGSPNYAAPEVI--NG 204

  Fly   357 REAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQM 421
            :.....:||:||.|:||:..|.|.|||.||:.....:::..  ..|..|.:  :|..|:.||.:|
pombe   205 KLYAGPEVDVWSCGIVLYVMLVGRLPFDDEFIPNLFKKVNS--CVYVMPDF--LSPGAQSLIRRM 265

  Fly   422 LIVDPERRPSIDDVLQSSW 440
            ::.||.:|.:|.::.:..|
pombe   266 IVADPMQRITIQEIRRDPW 284

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	95/279 (34%)
		S_TKc	174..441	CDD:214567	91/268 (34%)
ssp2	NP_588376.1	STKc_AMPK_alpha	31..285	CDD:270981	91/271 (34%)
		S_TKc	34..285	CDD:214567	91/268 (34%)
		UBA_SNF1_fungi	305..351	CDD:270519
		AdenylateSensor	451..573	CDD:293187
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910