DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and Dclk3

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_766516.2	Gene:	Dclk3 / 245038	MGIID:	3039580	Length:	790	Species:	Mus musculus

Alignment Length:	280	Identity:	95/280 - (33%)
Similarity:	168/280 - (60%)	Gaps:	24/280 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   169 EINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMK 233
            ::.|.|.:...:|.|.:..|:......|.|.:|||::.|:.|.|..        |.|.:|..|::
Mouse   509 DVEKHYDIGGVIGDGNFATVKECRHRETKQAYAMKMIDKSQLKGKE--------DIVDSEILIIQ 565

  Fly   234 NLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRG 298
            :||||.:|::|::.:....:|:::|:::||||.:.|:.|....|..:.:....:|.|:.::||:.
Mouse   566 SLSHPNIVKLHEVYETEAEIYLIMEYVQGGDLFDAIVENVKFPEPEAAVMITDLCKALVHMHDKN 630

  Fly   299 ITHRDLKPDNVLLETNDEETL-LKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTK 362
            |.|||:||:|:|::.|::::: ||::||||:|:|.:.  :.|:||||.|||||:|   ..:.|..
Mouse   631 IVHRDVKPENLLVQRNEDKSITLKLADFGLAKYVVRP--IFTVCGTPTYVAPEIL---SEKGYGL 690

  Fly   363 KVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQ------IKKGRFAYGHPSWKSVSQRAKLLINQM 421
            :||:|:.||:|:..|.|..||.    :|...|      |:.|:|.:..|.|.::|..||.|:..:
Mouse   691 EVDMWAAGVILYILLCGFPPFR----SPERDQDELFNIIQVGQFEFLSPYWDNISDAAKDLVRNL 751

  Fly   422 LIVDPERRPSIDDVLQSSWL 441
            |.|||::|.:.:.|||..|:
Mouse   752 LEVDPKKRYTAEQVLQHPWI 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	94/278 (34%)
		S_TKc	174..441	CDD:214567	93/273 (34%)
Dclk3	NP_766516.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..37
		UBQ	92..177	CDD:294102
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	201..290
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	315..506
		PKc_like	513..770	CDD:304357	93/273 (34%)
		S_TKc	514..771	CDD:214567	93/273 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101842
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810