DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lok and ALK

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_004295.2	Gene:	ALK / 238	HGNCID:	427	Length:	1620	Species:	Homo sapiens

Alignment Length:	332	Identity:	81/332 - (24%)
Similarity:	134/332 - (40%)	Gaps:	58/332 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 ISLSHPTYK------AFVFKDLSPN-------ESIG-LPEEINKTYYVNRKLGSGAYGLVRLVYD 193
            :.|..|.||      :.:..|.:||       .||. |.|...|...:.|.||.||:|   .||:
Human  1071 MELQSPEYKLSKLRTSTIMTDYNPNYCFAGKTSSISDLKEVPRKNITLIRGLGHGAFG---EVYE 1132

  Fly   194 TRTC--------QQFAMKIVKKNMLSGARPSTNFSDPDRV--LNEAKIMKNLSHPCVVRMHDIVD 248
            .:..        .|.|:|.:.:..          |:.|.:  |.||.|:...:|..:||...:..
Human  1133 GQVSGMPNDPSPLQVAVKTLPEVC----------SEQDELDFLMEALIISKFNHQNIVRCIGVSL 1187

  Fly   249 KPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVK-------YLHDRGITHRDLKP 306
            :....:::||.|.||||.:.:...:......|.|....:.|..:       ||.:....|||:..
Human  1188 QSLPRFILLELMAGGDLKSFLRETRPRPSQPSSLAMLDLLHVARDIACGCQYLEENHFIHRDIAA 1252

  Fly   307 DNVLLETNDEETLLKVSDFGLSKFVQKDSVMRT--LCGTPL-YVAPEVLITGGREAYTKKVDIWS 368
            .|.||.......:.|:.|||:::.:.:.|..|.  ....|: ::.||..:.|   .:|.|.|.||
Human  1253 RNCLLTCPGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKWMPPEAFMEG---IFTSKTDTWS 1314

  Fly   369 LGVVLFTCLS-GTLPFSDEYGTPAAQQIKKGRFAYGH--PSWKSVSQRAKLLINQMLIVDPERRP 430
            .||:|:...| |.:|:..:......:.:..|    |.  |. |:.......::.|.....||.||
Human  1315 FGVLLWEIFSLGYMPYPSKSNQEVLEFVTSG----GRMDPP-KNCPGPVYRIMTQCWQHQPEDRP 1374

  Fly   431 SIDDVLQ 437
            :...:|:
Human  1375 NFAIILE 1381

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	4/18 (22%)
		STKc_Chk2	167..441	CDD:270986	71/294 (24%)
		S_TKc	174..441	CDD:214567	69/287 (24%)
ALK	NP_004295.2	MAM	266..427	CDD:279023
		MAM	266..424	CDD:99706
		LDLa	441..467	CDD:197566
		MAM	480..636	CDD:279023
		MAM	480..631	CDD:99706
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	650..674
		FXa_inhibition	987..1021	CDD:291342
		PTKc_ALK_LTK	1109..1385	CDD:270632	71/294 (24%)
		Pkinase_Tyr	1116..1383	CDD:285015	69/287 (24%)
		Inhibitor binding	1197..1199		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1408..1463
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1514..1540
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910