DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and TSSK2

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_443732.3	Gene:	TSSK2 / 23617	HGNCID:	11401	Length:	358	Species:	Homo sapiens

Alignment Length:	287	Identity:	102/287 - (35%)
Similarity:	155/287 - (54%)	Gaps:	25/287 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 KTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVL-NEAKIMKNL 235
            |.|.|...||.|:|..|:..|..|.....|:||:.:.     :..|:|  .:|.| .|..|:..:
Human    10 KGYIVGINLGKGSYAKVKSAYSERLKFNVAVKIIDRK-----KTPTDF--VERFLPREMDILATV 67

  Fly   236 SHPCVVRMHDIVDKPDS-VYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGI 299
            :|..:::.::|.:..|. :|:::|....||||..|.....|.||:::..|.|:..||||.||..|
Human    68 NHGSIIKTYEIFETSDGRIYIIMELGVQGDLLEFIKCQGALHEDVARKMFRQLSSAVKYCHDLDI 132

  Fly   300 THRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDS-----VMRTLCGTPLYVAPEVLITGGREA 359
            .|||||.:|:||   |::..:|:||||.||...:||     :.:|.||:..|.|||||.:   ..
Human   133 VHRDLKCENLLL---DKDFNIKLSDFGFSKRCLRDSNGRIILSKTFCGSAAYAAPEVLQS---IP 191

  Fly   360 YTKKV-DIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLI 423
            |..|| |||||||:|:..:.|::|:.|.......:..|:.|..:  |..|:::...|.||.:||.
Human   192 YQPKVYDIWSLGVILYIMVCGSMPYDDSDIRKMLRIQKEHRVDF--PRSKNLTCECKDLIYRMLQ 254

  Fly   424 VDPERRPSIDDVLQSSWLRDAPMLQKA 450
            .|..:|..||::|..|||:  |...||
Human   255 PDVSQRLHIDEILSHSWLQ--PPKPKA 279

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	97/276 (35%)
		S_TKc	174..441	CDD:214567	96/274 (35%)
TSSK2	NP_443732.3	STKc_TSSK1_2-like	10..272	CDD:271067	97/276 (35%)
		S_TKc	12..272	CDD:214567	96/274 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	302..358
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910