DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and SIK2

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_056006.1	Gene:	SIK2 / 23235	HGNCID:	21680	Length:	926	Species:	Homo sapiens

Alignment Length:	268	Identity:	83/268 - (30%)
Similarity:	151/268 - (56%)	Gaps:	16/268 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 YYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHP 238
            |.:...||.|.:.:|:|.....|..:.|:||:.|:.|...       :.:::..|.:|||.|.||
Human    20 YDIEGTLGKGNFAVVKLGRHRITKTEVAIKIIDKSQLDAV-------NLEKIYREVQIMKMLDHP 77

  Fly   239 CVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRD 303
            .:::::.:::....:|:|.|:.:.|::.:.:.::..|:|..::..|:|:..||.|.|.|.|.|||
Human    78 HIIKLYQVMETKSMLYLVTEYAKNGEIFDYLANHGRLNESEARRKFWQILSAVDYCHGRKIVHRD 142

  Fly   304 LKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTKKVDIWS 368
            ||.:|:||:.|..   :|::|||...|.:...::.|.||:|.|.||||.  .|::....::||||
Human   143 LKAENLLLDNNMN---IKIADFGFGNFFKSGELLATWCGSPPYAAPEVF--EGQQYEGPQLDIWS 202

  Fly   369 LGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSID 433
            :||||:..:.|.|||.........|::.:|||...:    .:|:..:.||.:||::||.:|.:|.
Human   203 MGVVLYVLVCGALPFDGPTLPILRQRVLEGRFRIPY----FMSEDCEHLIRRMLVLDPSKRLTIA 263

  Fly   434 DVLQSSWL 441
            .:.:..|:
Human   264 QIKEHKWM 271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	82/266 (31%)
		S_TKc	174..441	CDD:214567	82/266 (31%)
SIK2	NP_056006.1	STKc_SIK	19..271	CDD:270973	82/266 (31%)
		UBA_SIK2	297..341	CDD:270592
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	644..666
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	742..776
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..896
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910