DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and Pdik1l

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001157266.1	Gene:	Pdik1l / 230809	MGIID:	2385213	Length:	341	Species:	Mus musculus

Alignment Length:	350	Identity:	91/350 - (26%)
Similarity:	145/350 - (41%)	Gaps:	101/350 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 YYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRV---LNEAKIMKNL 235
            |.:.|::|.|:||:|......:|..:.|:|.::.:.            |:.|   |.|...:.::
Mouse     8 YDLIREVGRGSYGVVYEAVIRKTSARVAVKKIRCHA------------PENVELALREFWALSSI 60

  Fly   236 --SHP-------CVVRMHDIVDK-------------------------PDSVY---MVLEFMRGG 263
              .||       |:::...:|.|                         |.|.|   .|::|..||
Mouse    61 KSQHPNVIHLEECILQKDGMVQKMSHGSNSSLYLQLVETSLKGEIAFDPRSAYYLWFVMDFCDGG 125

  Fly   264 DLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVL-----LETNDEETLLKVS 323
            |:...::|.| .:...:..:..|:..|:.:||...|.||||||||:|     ::|:|.|..|||:
Mouse   126 DMNEYLLSRK-PNRKTNTSFMLQLSSALAFLHKNQIIHRDLKPDNILISQSRMDTSDLEPTLKVA 189

  Fly   324 DFGLSKFVQKDS------------VMRTLCGTPLYVAPEVLITGGREAYTKKVDIWSLGVVLFTC 376
            ||||||......            .:.|.|||..|:||||    ....||.|.||::||::::..
Mouse   190 DFGLSKVCSASGQNPEEPVSVNKCFLSTACGTDFYMAPEV----WEGHYTAKADIFALGIIIWAM 250

  Fly   377 LSGTLPFSD---------EYGTPAAQQIKKGRFAYGHPSW--------KSVSQRAKLLINQMLIV 424
            |. .:.|.|         .|.....:.:..|.....:|..        ||::.|.|.||.:||..
Mouse   251 LE-RITFIDTETKKELLGSYVKQGTEIVPVGEALLENPKMELLIPVKKKSMNGRMKQLIKEMLAA 314

  Fly   425 DPERRPSIDDV---------LQSSW 440
            :|:.||...::         ..|||
Mouse   315 NPQDRPDAFELELRLVQIAFKDSSW 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	90/349 (26%)
		S_TKc	174..441	CDD:214567	90/349 (26%)
Pdik1l	NP_001157266.1	STKc_PDIK1L	7..331	CDD:270879	88/340 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910