DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and STK38L

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_024304657.1	Gene:	STK38L / 23012	HGNCID:	17848	Length:	521	Species:	Homo sapiens

Alignment Length:	344	Identity:	84/344 - (24%)
Similarity:	133/344 - (38%)	Gaps:	108/344 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 LGSGAYGLVRLVYDTRTCQQFAMKIVKK-NMLSGARPSTNFSDPDRVLNEAKIMKNLSHPCVVRM 243
            :|.||:|.||||....|...:||||::| :||...:.:       .:..|..|:.......||:|
Human    96 IGRGAFGEVRLVQKKDTGHIYAMKILRKSDMLEKEQVA-------HIRAERDILVEADGAWVVKM 153

  Fly   244 HDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDN 308
            ........::|:::||:.|||::..::....|:|:.::.|..:...|:..:|..|..|||:||||
Human   154 FYSFQDKRNLYLIMEFLPGGDMMTLLMKKDTLTEEETQFYISETVLAIDAIHQLGFIHRDIKPDN 218

  Fly   309 VLLETNDEETLLKVSDFGL------------------------------------------SKFV 331
            :||   |.:..:|:|||||                                          .|.:
Human   219 LLL---DAKGHVKLSDFGLCTGLKKAHRTEFYRNLTHNPPSDFCKFGCCFSSFPWLRYCREQKVL 280

  Fly   332 QKDSVMRTLC---------------------------------------------------GTPL 345
            ....::..||                                                   |||.
Human   281 SLSPLLNPLCFRCICIFFLWRAFFPRDYNSILLKLAFQNMNSKRKAETWKKNRRQLAYSTVGTPD 345

  Fly   346 YVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSV 410
            |:||||.:..|   |.|..|.|||||:::..|.|..||..|......:::...:.....|....:
Human   346 YIAPEVFMQTG---YNKLCDWWSLGVIMYEMLIGYPPFCSETPQETYRKVMNWKETLVFPPEVPI 407

  Fly   411 SQRAKLLINQMLIVDPERR 429
            |::||.||.:..| |.|.|
Human   408 SEKAKDLILRFCI-DSENR 425

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	84/344 (24%)
		S_TKc	174..441	CDD:214567	84/344 (24%)
STK38L	XP_024304657.1	STKc_NDR2	87..509	CDD:270776	84/344 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910