DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and unc-51

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_507869.1	Gene:	unc-51 / 180311	WormBaseID:	WBGene00006786	Length:	856	Species:	Caenorhabditis elegans

Alignment Length:	309	Identity:	99/309 - (32%)
Similarity:	161/309 - (52%)	Gaps:	42/309 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 EEINKTYYVNRK-LGSGAYGLV-RLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAK 230
            |:.:...|..|. ||.||:.:| |..|..||....|:|.:.|..:|.::        :.:..|.|
Worm     2 EQFDGFEYSKRDLLGHGAFAIVYRGRYVDRTDVPVAIKAIAKKNISKSK--------NLLTKEIK 58

  Fly   231 IMKNLS---HPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVK 292
            |:|.||   |..:|.:....:.|..||:|:||..||||.:.:.....|:||..:.:..|:.||::
Worm    59 ILKELSSLKHENLVGLLKCTETPTHVYLVMEFCNGGDLADYLQQKTTLNEDTIQHFVVQIAHALE 123

  Fly   293 YLHDRGITHRDLKPDNVLLETNDE-------ETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPE 350
            .::.:||.||||||.|:||..|..       :.::|::|||.::|:....:..||||:|:|:|||
Worm   124 AINKKGIVHRDLKPQNILLCNNSRTQNPHFTDIVIKLADFGFARFLNDGVMAATLCGSPMYMAPE 188

  Fly   351 VLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAY---------GHPS 406
            |:::   ..|..|.|:||:|.:||.||:|..||..:  ||  .|:|    ||         ..|.
Worm   189 VIMS---MQYDAKADLWSIGTILFQCLTGKAPFVAQ--TP--PQLK----AYYEKTRELRPNIPE 242

  Fly   407 WKSVSQRAKLLINQMLIVDPERRPSIDDVLQSSWLRDAPMLQKAKRLMK 455
            |.|.:.|..||  ::|..:.:.|.|.:|.....:|....:...:||:::
Worm   243 WCSPNLRDLLL--RLLKRNAKDRISFEDFFNHPFLTSPLLPSPSKRILE 289

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	96/293 (33%)
		S_TKc	174..441	CDD:214567	95/287 (33%)
unc-51	NP_507869.1	S_TKc	9..275	CDD:214567	95/286 (33%)
		STKc_ULK1_2-like	15..274	CDD:271022	93/279 (33%)
		DUF3543	647..848	CDD:288883
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910