DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and cmk-1

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_500139.1	Gene:	cmk-1 / 176989	WormBaseID:	WBGene00000553	Length:	348	Species:	Caenorhabditis elegans

Alignment Length:	284	Identity:	103/284 - (36%)
Similarity:	151/284 - (53%)	Gaps:	19/284 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 SPNESIGLPEEINKTYYVNRKLGSGAYGLVRLVYDTRTC-QQFAMKIVKKNMLSGARPSTNFSDP 222
            :||.:      |.:.|.....||:||:..|.|....... |.:|:|.:.|..|.|...|..
Worm    13 APNAT------IREKYDFRDVLGTGAFSKVFLAESKSDAGQMYAVKCIDKKALKGKEESLE---- 67

  Fly   223 DRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQM 287
                ||.|:::.|.|..:|::.|..|:...||:|:|.:.||:|.:||::....:|..:.....|:
Worm    68 ----NEIKVLRKLRHNNIVQLFDTYDEKQFVYLVMELVTGGELFDRIVAKGSYTEQDASNLIRQV 128

  Fly   288 CHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVL 352
            ..||.::||.|:.||||||:|:|....||::.:.:||||||| .:...||.|.||||.|||||||
Worm   129 LEAVGFMHDNGVVHRDLKPENLLYYNQDEDSKIMISDFGLSK-TEDSGVMATACGTPGYVAPEVL 192

  Fly   353 ITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLL 417
               .::.|.|.||:||:||:.:..|.|..||.||.......||.||.:.:..|.|..:|..||..
Worm   193 ---QQKPYGKAVDVWSIGVIAYILLCGYPPFYDESDANLFAQIIKGEYEFDAPYWDQISDSAKDF 254

  Fly   418 INQMLIVDPERRPSIDDVLQSSWL 441
            |..::..|||.|.:..|.|...|:
Worm   255 ITHLMCCDPEARFTCQDALSHPWI 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	100/274 (36%)
		S_TKc	174..441	CDD:214567	99/267 (37%)
cmk-1	NP_500139.1	STKc_CaMKI	18..277	CDD:270985	100/270 (37%)
cmk-1	NP_500139.1	S_TKc	22..278	CDD:214567	99/267 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910