DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and nek8

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_620776.1	Gene:	nek8 / 171094	ZFINID:	ZDB-GENE-020509-1	Length:	697	Species:	Danio rerio

Alignment Length:	274	Identity:	88/274 - (32%)
Similarity:	145/274 - (52%)	Gaps:	27/274 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 EEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVL--NEAK 230
            |:..||    :.:|.||:|:|.|   .|.....|:.|:|:      .|....:..:|:.  ||.:
Zfish     2 EKYEKT----KVVGRGAFGIVHL---CRRRTDSALVILKE------IPVEQMTRDERLAAQNECQ 53

  Fly   231 IMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIIS--NKLLSEDISKLYFYQMCHAVKY 293
            ::|.||||.::..::...:..::.:.:|:..||.|.:.|..  |.||.||.....|.|:..|:.:
Zfish    54 VLKLLSHPNIIEYYENFLEDKALMIAMEYAPGGTLADYIQKRCNSLLDEDTILHSFVQILLALYH 118

  Fly   294 LHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGRE 358
            :|::.|.|||||..|:||:.:  :.::|:.|||:||.:...|...|:.|||.|::|| |..|  :
Zfish   119 VHNKLILHRDLKTQNILLDKH--QMIVKIGDFGISKILVSKSKAYTVVGTPCYISPE-LCEG--K 178

  Fly   359 AYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPA-AQQIKKGRFAYGHPSWKSVSQRAKLLINQML 422
            .|.:|.|||:||.||:...|....| :....|| ..:|..|.||   |.....|...:.||..||
Zfish   179 PYNQKSDIWALGCVLYELASLKRAF-EAANLPALVLKIMSGTFA---PISDRYSPELRQLILNML 239

  Fly   423 IVDPERRPSIDDVL 436
            .:||.:||.:::::
Zfish   240 NLDPSKRPQLNEIM 253

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	88/274 (32%)
		S_TKc	174..441	CDD:214567	85/268 (32%)
nek8	NP_620776.1	STKc_Nek8	3..258	CDD:270859	87/273 (32%)
		S_TKc	4..255	CDD:214567	87/272 (32%)
		ATS1	309..662	CDD:227511
		RCC1 1	417..468
		RCC1 2	469..520
		RCC1 3	521..586
		RCC1 4	587..636
		RCC1 5	637..689
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910