DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lok and PNCK

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001034671.3	Gene:	PNCK / 139728	HGNCID:	13415	Length:	426	Species:	Homo sapiens

Alignment Length:	274	Identity:	98/274 - (35%)
Similarity:	152/274 - (55%)	Gaps:	12/274 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   168 EEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIM 232
            |:|:..|.:..:|||||:..|.|..:..:....|:|.:.|..|.|...        .|.||..::
Human    92 EDISSVYEIRERLGSGAFSEVVLAQERGSAHLVALKCIPKKALRGKEA--------LVENEIAVL 148

  Fly   233 KNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDR 297
            :.:|||.:|.:.|:.:.|..:|:.:|.:.||:|.:||:.....:|..:.....|:..||.|||..
Human   149 RRISHPNIVALEDVHESPSHLYLAMELVTGGELFDRIMERGSYTEKDASHLVGQVLGAVSYLHSL 213

  Fly   298 GITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTK 362
            ||.||||||:|:|..|..|::.:.|||||||| :|..:::.|.||||.|||||:|   .::.|.|
Human   214 GIVHRDLKPENLLYATPFEDSKIMVSDFGLSK-IQAGNMLGTACGTPGYVAPELL---EQKPYGK 274

  Fly   363 KVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPE 427
            .||:|:|||:.:..|.|..||.||.......||.:..:.:..|.|..:|:.||..|..:|..||:
Human   275 AVDVWALGVISYILLCGYPPFYDESDPELFSQILRASYEFDSPFWDDISESAKDFIRHLLERDPQ 339

  Fly   428 RRPSIDDVLQSSWL 441
            :|.:....|:..|:
Human   340 KRFTCQQALRHLWI 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	97/272 (36%)
		S_TKc	174..441	CDD:214567	95/266 (36%)
PNCK	NP_001034671.3	STKc_CaMKI_beta	94..370	CDD:271071	97/272 (36%)
PNCK	NP_001034671.3	S_TKc	98..353	CDD:214567	95/266 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910