DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and Dapk2

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_036010488.1	Gene:	Dapk2 / 13143	MGIID:	1341297	Length:	490	Species:	Mus musculus

Alignment Length:	308	Identity:	84/308 - (27%)
Similarity:	152/308 - (49%)	Gaps:	19/308 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   159 SPNESIGLPEEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPD 223
            |||......:::...|.:..:||||.:.:|:...:..|..::|.|.:||.....:|......:.:
Mouse     8 SPNMETFKQQKVEDFYDIGEELGSGQFAIVKKCREKSTGLEYAAKFIKKRQSRASRRGVCREEIE 72

  Fly   224 RVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMC 288
            |   |..|::.:.||.::.:||:.:....|.::||.:.||:|.:.:...:.|||:.:..:..|:.
Mouse    73 R---EVSILRQVLHPNIITLHDVYENRTDVVLILELVSGGELFDFLAQKESLSEEEATSFIKQIL 134

  Fly   289 HAVKYLHDRGITHRDLKPDNV-LLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVL 352
            ..|.|||.:.|.|.||||:|: ||:.|.....:|:.||||:..::.....:.:.|||.:||||::
Mouse   135 DGVNYLHTKKIAHFDLKPENIMLLDKNIPIPHIKLIDFGLAHEIEDGVEFKNIFGTPEFVAPEIV 199

  Fly   353 ITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLL 417
               ..|....:.|:||:||:.:..|||..||..:........|....:.:....:...|:.||..
Mouse   200 ---NYEPLGLEADMWSIGVITYILLSGASPFLGDTKQETLANITAVSYDFDEEFFSQTSELAKDF 261

  Fly   418 INQMLIVDPERRPSIDDVLQSSWL------------RDAPMLQKAKRL 453
            |.::|:.:..:|.:|.:.|:..|:            :..|...|.|||
Mouse   262 IRKLLVKETRKRLTIQEALRHPWITSKGEARAPEQWKAQPAQLKTKRL 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	75/274 (27%)
		S_TKc	174..441	CDD:214567	75/267 (28%)
Dapk2	XP_036010488.1	STKc_DAPK2	17..285	CDD:271098	75/273 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910