DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and AgaP_AGAP009784

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_318879.3	Gene:	AgaP_AGAP009784 / 1279197	VectorBaseID:	AGAP009784	Length:	462	Species:	Anopheles gambiae

Alignment Length:	470	Identity:	232/470 - (49%)
Similarity:	299/470 - (63%)	Gaps:	39/470 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DTQGTQGTQSQASNIWTQVESQPMEKIVWGRLYGKNIKIKSLGTSSKYRIIYTHSSFSVDLNNDE 68
            |||  ..||:|.:.. |.:||||:|...:|:|.||::|:|||                 ||.:.|
Mosquito     9 DTQ--TATQTQMTQD-TALESQPIEHPSYGQLLGKHVKMKSL-----------------DLRHSE 53

  Fly    69 FTAGRGEANDLILTLNDLPEKILTRISKVHFIIKRANCELTNPVYIQDLSRNGTFVNNEKIGTNR 133
            |..||.....|||..::||...|.||||.||.||:...:.|:|.||.|.|||||:||...||.|:
Mosquito    54 FKVGREGTCHLILDEDNLPPSKLCRISKHHFTIKKDLNDTTSPTYIHDHSRNGTYVNGRLIGPNK 118

  Fly   134 MRILKNDDVISLSHPTYKAFVFKDL--SPNESIGLPEEINKTYYVNRKLGSGAYGLVRLVYDTRT 196
            ..|||::|:||::..:.:|||:.||  |....|...|.::: |:|.|||||||.|.|.|::||.:
Mosquito   119 CMILKHNDIISIAGVSIRAFVYYDLRYSMQSDIKAKELLDR-YHVGRKLGSGACGTVYLLHDTVS 182

  Fly   197 CQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMR 261
            ||.:|||.|.|:.|:........:||.||:||..|||||.||||::||||||||||||||||:|:
Mosquito   183 CQPYAMKHVAKDPLNERSRPKFLNDPLRVMNEVNIMKNLDHPCVIKMHDIVDKPDSVYMVLEYMK 247

  Fly   262 GGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRG------ITHRDLKPDNVL--LETNDEET 318
            |||||:||||...|.|..:||:|.||||||||||::|      .|.|.:...||.  ..|..:.|
Mosquito   248 GGDLLSRIISKGFLPEKTAKLFFLQMCHAVKYLHEQGKLECCENTQRTISSLNVAGRKSTKSDRT 312

  Fly   319 LLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPF 383
            |   ..|.|..|    ::....|....:|..|||.||||.:||:|||||||||||||.|||||||
Mosquito   313 L---EGFVLLTF----ALPFGFCSHLSHVEKEVLQTGGRGSYTRKVDIWSLGVVLFTMLSGTLPF 370

  Fly   384 SDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSIDDVLQSSWLRDAPMLQ 448
            |||||:||.:|||:|.|...|..||.||..||.||..:|.|:|..|||||.:||||||||..::.
Mosquito   371 SDEYGSPAVEQIKRGNFKMRHSVWKQVSSLAKKLIYDILNVNPHSRPSIDTLLQSSWLRDPDIVG 435

  Fly   449 KAKRLMKLDGMEIEE 463
            :|::|||: .:.:||
Mosquito   436 RAEQLMKI-SLRVEE 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	48/116 (41%)
		STKc_Chk2	167..441	CDD:270986	154/281 (55%)
		S_TKc	174..441	CDD:214567	153/274 (56%)
AgaP_AGAP009784	XP_318879.3	FHA	50..139	CDD:238017	40/88 (45%)
		PKc_like	154..428	CDD:304357	154/281 (55%)
		S_TKc	160..428	CDD:214567	153/274 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	374	1.000	Domainoid score	I2469
eggNOG	1	0.900	-	-		E1_KOG0615
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38289
Inparanoid	1	1.050	486	1.000	Inparanoid score	I3163
OMA	1	1.010	-	-		QHG53505
OrthoDB	1	1.010	-	-		D108379at50557
OrthoFinder	1	1.000	-	-		FOG0002433
OrthoInspector	1	1.000	-	-		oto106399
Panther	1	1.100	-	-	LDO	PTHR44167
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1619
TreeFam	1	0.960	-	-
	13	12.940