DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and AgaP_AGAP008341

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_317116.4	Gene:	AgaP_AGAP008341 / 1277641	VectorBaseID:	AGAP008341	Length:	457	Species:	Anopheles gambiae

Alignment Length:	464	Identity:	195/464 - (42%)
Similarity:	275/464 - (59%)	Gaps:	40/464 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 QVESQPME--------------KIVWGRLYGKNIKIKSLGTSSKYRI-IYTHSS--------FSV 62
            ::.:||::              :..:|:|.|.:.....:|.....|: :.|..|        |..
Mosquito     3 EIATQPLDSETISMDLLTSQTPQSSYGQLVGNSALFGIIGEFLVLRLALETRFSCQFQEQFHFVA 67

  Fly    63 DLNNDEFTAGRGEANDLILTLNDLPEKILTRISKVHFIIKRANCELTNPVYIQDLSRNGTFVNNE 127
            ||.:::|..||.....|.:.....|..|.:.||.:||.:::...:...|.||.|.|.|||:||.:
Mosquito    68 DLCSEKFNVGRDRRCSLAIDEVHFPLPIRSFISNIHFTLEKDLTDRYTPTYIIDNSTNGTYVNGK 132

  Fly   128 KIGTNRMRILKNDDVISLSHPTYKAFVFKDLSPNESIGLPEEI-----NKTYYVNRKLGSGAYGL 187
            .:|.|...||.....||:: .....||:.    .....:|.|:     .|.|::.|.||||::|.
Mosquito   133 LVGRNNRAILLPGSTISIA-CFANIFVYN----QHDYRVPPEVESQALRKRYHIGRTLGSGSFGT 192

  Fly   188 VRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDS 252
            |.:::|..|||.:|:|||||.     |..|.......:.|||.|||.|:||||:||.|.::.|.|
Mosquito   193 VYMLHDVTTCQPYALKIVKKQ-----RYGTKLRGSPSLTNEANIMKKLNHPCVIRMFDFINDPGS 252

  Fly   253 VYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEE 317
            :.||||:|:|||||.||:.|..|.||.:|.||||:|||:.|||.:||||||||||||||:.|||.
Mosquito   253 ISMVLEYMQGGDLLTRIMDNGYLPEDTAKFYFYQLCHAIHYLHSQGITHRDLKPDNVLLKDNDEY 317

  Fly   318 TLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLP 382
            ||:||||||.|||:.....|||:||||.|||||||.:.|::.||::||:|||||||:|.|||.||
Mosquito   318 TLIKVSDFGSSKFLDHTIFMRTICGTPEYVAPEVLESNGQKPYTRQVDVWSLGVVLYTMLSGLLP 382

  Fly   383 FSDEYG-TPAAQQIKKGRFAYGHPSWKSV-SQRAKLLINQMLIVDPERRPSIDDVLQSSWLRDAP 445
            |....| |.||:.:.:|.|:...|.|::| |.|.|.||..:|.|||:.|||::.:|.|.|.|::.
Mosquito   383 FGTMNGMTDAAELVMRGNFSMAQPVWRTVRSFRPKKLIYDILNVDPDERPSVEMLLDSVWFRNSD 447

  Fly   446 MLQKAKRLM 454
            ::|.|:.:|
Mosquito   448 VVQHAQAMM 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	35/125 (28%)
		STKc_Chk2	167..441	CDD:270986	150/280 (54%)
		S_TKc	174..441	CDD:214567	147/268 (55%)
AgaP_AGAP008341	XP_317116.4	PKc_like	173..442	CDD:304357	148/273 (54%)
AgaP_AGAP008341	XP_317116.4	S_TKc	179..443	CDD:214567	147/268 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0615
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53505
OrthoDB	1	1.010	-	-		D1510589at2759
OrthoFinder	1	1.000	-	-		FOG0002433
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44167
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1619
TreeFam	1	0.960	-	-
	8	7.890