DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lok and AgaP_AGAP003108

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_562866.4	Gene:	AgaP_AGAP003108 / 1273778	VectorBaseID:	AGAP003108	Length:	941	Species:	Anopheles gambiae

Alignment Length:	311	Identity:	69/311 - (22%)
Similarity:	133/311 - (42%)	Gaps:	67/311 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   167 PEEINKTY-----YVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVL 226
            |.::|..:     ::.:.||.|.:|.|.:.......:.....:|...||.......:..|   ::
Mosquito   590 PIDLNWEFPRNKLHLGKSLGEGMFGKVVMAEAHGLVKGHPSTVVAVKMLKEGHTDADVKD---LV 651

  Fly   227 NEAKIMKNL-SHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLN-----RIISN---------KLLS 276
            .|.::||.: .|..::.:.....|...:|:::|:...|:|.|     |..||         |:|:
Mosquito   652 CEMEVMKMIGKHVNIINLLGCCCKDGPLYVIVEYAPHGNLKNFLRSHRFGSNYEATNEKEKKILT 716

  Fly   277 EDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMR-TL 340
            :.....:.||:...:::|..|...||||...|:|:..|   .::|::||||::.:......| |.
Mosquito   717 QKELISFAYQIARGMEHLASRRCIHRDLAARNILVSDN---YVMKIADFGLARDIHDQEYYRKTT 778

  Fly   341 CG-TPL-YVAPEVLITGGREAYTKKVDIWSLGVVLFTCLS-GTLPFSDEYGTPAAQQIKKGRFAY 402
            .| .|: ::|||.|   ..:.|..:.|:||.||:|:..:: |..|:      |:.
Mosquito   779 TGKLPIRWMAPESL---EEKFYDSQSDVWSFGVLLWEIMTLGGNPY------PSI---------- 824

  Fly   403 GHPSWKSVSQRAK----------------LLINQMLIVDPERRPSIDDVLQ 437
              |:|.::.:..|                |.:.:.....||.||:..:::|
Mosquito   825 --PTWDNLLEHLKKGKRMEKPPLCSIEIYLFMRECWHYRPEERPTFSEIVQ 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	69/311 (22%)
		S_TKc	174..441	CDD:214567	67/304 (22%)
AgaP_AGAP003108	XP_562866.4	I-set	95..170	CDD:254352
		Ig	98..170	CDD:299845
		Ig	291..370	CDD:299845
		IG_like	293..370	CDD:214653
		IG_like	384..473	CDD:214653
		Ig	393..474	CDD:299845
		PKc_like	590..880	CDD:304357	69/311 (22%)
		STYKc	602..875	CDD:214568	67/299 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910