DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and AgaP_AGAP002710

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_312218.5	Gene:	AgaP_AGAP002710 / 1273258	VectorBaseID:	AGAP002710	Length:	1023	Species:	Anopheles gambiae

Alignment Length:	352	Identity:	90/352 - (25%)
Similarity:	146/352 - (41%)	Gaps:	92/352 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 VKKNMLSGARPSTNFSDPD--------RVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMR 261
            |.:..|:|...:...|..|        .||.|||:..:|.||.:|.:..:...|.::.:|:|:.|
Mosquito   117 VHRAFLNGEEVAVKASRQDDEFEVARQNVLQEAKLFWSLKHPNIVSLKGVCLDPKTLCLVMEYAR 181

  Fly   262 GGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDR---GITHRDLKPDNVLLETNDE-----ET 318
            ||. ||:|::.:.:..::...:..|:...:||||..   .:.|||||..|||:..:.:     ..
Mosquito   182 GGS-LNKILAGRKIPPNVLVDWAIQIARGMKYLHCEAPISVIHRDLKSSNVLISESIQHGHLLNK 245

  Fly   319 LLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPF 383
            .||::||||::...:.:.| :..||..::.|||:.:|   .|:|..|:||.||:|:..|:|..|:
Mosquito   246 TLKITDFGLAREAYRTTRM-SAAGTFAWMPPEVIKSG---TYSKASDVWSYGVLLWELLTGETPY 306

  Fly   384 SDEYGTPAAQQIKKGRFAYGHP-----SWKSVSQRAKLLINQMLIVDPERRPSIDDV-------- 435
            ........|..:.....|...|     ||..       |:.....:||.||||..|:
Mosquito   307 KGFDSLSVAYGVAVNTLALPIPKTCPESWGK-------LMKSCWEIDPHRRPSFKDIEKDLDIIA 364

  Fly   436 --------------LQSSWLRD-APMLQK-----------------------------AKRLMKL 456
                          :|..|.:: |.:||:                             |||..:|
Mosquito   365 RSGFAQTPHESFHTMQDGWKKEIAEVLQELRKKEKELRSKEEELTRVQQEQRYKEENLAKREQEL 429

  Fly   457 DGMEIE----EENFL---EPPTKRSRR 476
            ...|||    |...|   ..||.:.|:
Mosquito   430 HAREIELLGRELKILINQNTPTPKKRK 456

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	74/278 (27%)
		S_TKc	174..441	CDD:214567	74/278 (27%)
AgaP_AGAP002710	XP_312218.5	SH3_MLK	28..84	CDD:212809
		STYKc	103..360	CDD:214568	73/254 (29%)
		STKc_MLK	108..363	CDD:270963	73/257 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910