DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lok and AgaP_AGAP002250

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_307935.5	Gene:	AgaP_AGAP002250 / 1269312	VectorBaseID:	AGAP002250	Length:	1114	Species:	Anopheles gambiae

Alignment Length:	552	Identity:	140/552 - (25%)
Similarity:	239/552 - (43%)	Gaps:	119/552 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 TQGTQGTQSQASNIWTQVESQP---MEKIVWGRLYGKNIKIKSLGTSSK---------------- 50
            |..|..|.|.|:|..|...|:|   ..:..:...:...:...|.|:||.
Mosquito   492 TTTTTSTTSVATNTVTGRTSKPPLHSYQHHYQSYHHHQLSTDSCGSSSSGGGVPPAVSMVAGGGT 556

  Fly    51 YRIIYTHS-------------SFSVDL--NNDEFTAGRGEANDLILT-------LNDLPEKILTR 93
            ||   :||             :.|:||  |:|...|.....:.|.::       ...|..::|.:
Mosquito   557 YR---SHSARFMTQHIKILPKTQSLDLADNDDMLEASNRSESQLEISAAGIGPGAGGLRGRVLPK 618

  Fly    94 ISKVHFIIKRANCELTNPVY--IQDLSRNGTFVNNEKIGTNRMRILKNDDVISLSHPTYKAFVFK 156
            :..:.        :.|.|:|  :.....|..: .:.:.|..|.. |:....:|:
Mosquito   619 LQTLE--------QTTRPIYPNVPYSPYNSPY-GSPRSGRRRTP-LRESRRVSI----------- 662

  Fly   157 DLSPNESIGLPEEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNML---SGAR---P 215
                 |..|...::|: |.:..::|.|:||||:|.|.......:||||:.|..|   :|..   |
Mosquito   663 -----EQSGSFLQLNQ-YKLLDQIGQGSYGLVKLAYSEEDSTHYAMKILSKRKLLRKAGLMRRGP 721

  Fly   216 STNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKP--DSVYMVLEFMRGGDLLNRIISNKLLSED 278
            ....|..|||..|..::|.|.||.||::.:::|.|  ||:|:|.|.::.|::|: |.:...|||:
Mosquito   722 KRGTSPLDRVYREIAVLKKLDHPNVVKLVEVLDDPLEDSLYLVFELVQQGEVLS-IPTETPLSEE 785

  Fly   279 ISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGL-SKFVQKDSVMR--TL 340
            .:...|..:...|:|||.:.|.|.||||.|:||..:..   :||:|.|: ::|:.:|:.|.  :.
Mosquito   786 RAWNVFRDVLLGVEYLHYQRIIHGDLKPANLLLSDSGS---VKVADLGVCNEFLGEDAAMNNGST 847

  Fly   341 CGTPLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAY--- 402
            .|||.:.|||.|:.|......|..|||:||..||:.:.|.:||.........::||.....:
Mosquito   848 AGTPAFRAPETLLPGQHFYNGKAADIWALGATLFSLVHGNVPFIATSVPGVYEKIKNDPLEFPAN 912

  Fly   403 --GHPSWKSVSQRAKLLINQMLIVDPERRPSIDDVLQSSW--------------------LRDAP 445
              ..|: .::|:..:.||::||..||::|.::..:.:..|                    :.|..
Mosquito   913 CSSAPA-STISEELRDLISRMLDKDPQQRITLPQIKEHPWMTKHGTVRLPSEEENCRLVQISDED 976

  Fly   446 MLQKAKRLMKLDGM-----EIEEENFLEPPTK 472
            |....|.:.|||.:     .:::.:|..|.||
Mosquito   977 MSSVVKSIPKLDTLILIKTMLKKHSFQNPFTK 1008

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	25/156 (16%)
		STKc_Chk2	167..441	CDD:270986	94/309 (30%)
		S_TKc	174..441	CDD:214567	93/302 (31%)
AgaP_AGAP002250	XP_307935.5	S_TKc	674..952	CDD:214567	92/282 (33%)
AgaP_AGAP002250	XP_307935.5	PKc_like	679..953	CDD:304357	92/278 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910