DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and Cdk6

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_034003.1	Gene:	Cdk6 / 12571	MGIID:	1277162	Length:	326	Species:	Mus musculus

Alignment Length:	316	Identity:	77/316 - (24%)
Similarity:	140/316 - (44%)	Gaps:	66/316 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   171 NKTYYVNRKLGSGAYGLVRLVYDTRTCQQF-AMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKN 234
            ::.|....::|.||||.|....|.:...:| |:|.|:........|.:       .:.|..::::
Mouse    10 DQQYECVAEIGEGAYGKVFKARDLKNGGRFVALKRVRVQTSEEGMPLS-------TIREVAVLRH 67

  Fly   235 L---SHPCVVRMHDI-----VDKPDSVYMVLEFMRGGDL---LNRIISNKLLSEDISKLYFYQMC 288
            |   .||.|||:.|:     .|:...:.:|.|.: ..||   |:::....:.:|.|..:.| |:.
Mouse    68 LETFEHPNVVRLFDVCTVSRTDRETKLTLVFEHV-DQDLTTYLDKVPEPGVPTETIKDMMF-QLL 130

  Fly   289 HAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLI 353
            ..:.:||...:.||||||.|:|:.::.:   :|::||||::.......:.::..|..|.|||||:
Mouse   131 RGLDFLHSHRVVHRDLKPQNILVTSSGQ---IKLADFGLARIYSFQMALTSVVVTLWYRAPEVLL 192

  Fly   354 TGGREAYTKKVDIWSLGVV---------LFTCLSGT-----------LPFSDE-----------Y 387
               :.:|...||:||:|.:         ||...|..           ||..::           :
Mouse   193 ---QSSYATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDIIGLPGEEDWPRDVALPRQAF 254

  Fly   388 GTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSIDDVLQSSWLRD 443
            .:.:||.|:|  |.      ..:.:..|.|:.:.|..:|.:|.|....|...:.:|
Mouse   255 HSKSAQPIEK--FV------TDIDELGKDLLLKCLTFNPAKRISAYGALNHPYFQD 302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	76/312 (24%)
		S_TKc	174..441	CDD:214567	76/309 (25%)
Cdk6	NP_034003.1	STKc_CDK6	11..300	CDD:270846	76/311 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910