Protein Alignment lok and Chek2

DIOPT Version :10

• Sequence 1: NP_477219.1
• Gene: lok / 35288
• FlyBaseID: FBgn0019686
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: NP_446129.1
• Gene: Chek2 / 114212
• RGDID: 621543
• Length: 545
• Species: Rattus norvegicus
• Alignment Length: 490
• Identity: 187/490 - (38%)
• Similarity: 278/490 - (56%)
• Gaps: 56/490 - (11%)

  Fly     2 ARDTQGTQGTQSQASNIWTQ------VESQPME--KIVWGRLYGKNIKIKSLGTSSKYRIIYTHS 58
            ::.:..:.||.|....:.||      .:.:|.|  ...|.||:.                  ...
  Rat    58 SQSSHSSSGTLSSLETVSTQELCSIPEDQEPEEPGPTPWARLWA------------------LQD 104

  Fly    59 SFS-VDLNNDEFTAGRGEANDLILTLNDLP-----EKILTRISKVHFIIKR----ANCELTNPVY 113
            .|| :|..||.:..||.::.:...   |.|     :|..| .||.||.|.|    .||.:   ||
  Rat   105 GFSNLDCVNDNYWFGRDKSCEYCF---DGPLLKRTDKYRT-YSKKHFRIFREMGPKNCYI---VY 162

  Fly   114 IQDLSRNGTFVNNEKIGTNRMRILKNDDVISLSHPTYKAFVFKDLSPNESIGLPEEINKTYYVNR 178
            ::|.|.||||||.|.||..:...|.|:..|:||....|.|||.||:.::....|:|:...|.:::
  Rat   163 LEDHSGNGTFVNTELIGKGKRCPLSNNSEIALSLCRNKVFVFFDLTVDDQSVYPKELRDEYIMSK 227

  Fly   179 KLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSD-PDRVLNEAKIMKNLSHPCVVR 242
            .|||||.|.|::.::.:||::.|:||:.|...  |..|:..:| ...|..|.:|:|.|:|||:::
  Rat   228 TLGSGACGEVKMAFERKTCKKVAIKIISKRRF--ALGSSREADTAPSVETEIEILKKLNHPCIIK 290

  Fly   243 MHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPD 307
            :.|:.|..| .|:|||.|.||:|.:|::.||.|.|...|||||||..||:|||:.||.||||||:
  Rat   291 IKDVFDVED-YYIVLELMEGGELFDRVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPE 354

  Fly   308 NVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTKKVDIWSLGVV 372
            ||||.:.:|:.|:|::|||.||.:.:.|:||||||||.|:||||||:.|...|::.||.|||||:
  Rat   355 NVLLSSQEEDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLISNGTAGYSRAVDCWSLGVI 419

  Fly   373 LFTCLSGTLPFSDEYGTPAA--QQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSIDDV 435
            ||.||||..||| |:.|..:  .||..|::......|..||::|..|:.::|:|||:.|.:.::.
  Rat   420 LFICLSGYPPFS-EHKTQVSLKDQITSGKYNLIPEVWTDVSEKALDLVKKLLVVDPKARLTTEEA 483

  Fly   436 LQSSWLRDAPMLQKAKRLMKLDGMEIEEENFLEPP 470
            |...||:|..|.:|.:.|:      ::|:|.:..|
  Rat   484 LSHPWLQDEHMKKKFQDLL------VQEKNLVPLP 512

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA_CHK2	32..158	CDD:438718	44/135 (33%)
		STKc_Chk2	167..441	CDD:270986	125/276 (45%)
Chek2	NP_446129.1	FHA_CHK2	96..207	CDD:438718	44/135 (33%)
		STKc_Chk2	216..489	CDD:270986	125/276 (45%)