DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lok and Chek2

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_446129.1	Gene:	Chek2 / 114212	RGDID:	621543	Length:	545	Species:	Rattus norvegicus

Alignment Length:	490	Identity:	187/490 - (38%)
Similarity:	278/490 - (56%)	Gaps:	56/490 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ARDTQGTQGTQSQASNIWTQ------VESQPME--KIVWGRLYGKNIKIKSLGTSSKYRIIYTHS 58
            ::.:..:.||.|....:.||      .:.:|.|  ...|.||:.                  ...
  Rat    58 SQSSHSSSGTLSSLETVSTQELCSIPEDQEPEEPGPTPWARLWA------------------LQD 104

  Fly    59 SFS-VDLNNDEFTAGRGEANDLILTLNDLP-----EKILTRISKVHFIIKR----ANCELTNPVY 113
            .|| :|..||.:..||.::.:...   |.|     :|..| .||.||.|.|    .||.:   ||
  Rat   105 GFSNLDCVNDNYWFGRDKSCEYCF---DGPLLKRTDKYRT-YSKKHFRIFREMGPKNCYI---VY 162

  Fly   114 IQDLSRNGTFVNNEKIGTNRMRILKNDDVISLSHPTYKAFVFKDLSPNESIGLPEEINKTYYVNR 178
            ::|.|.||||||.|.||..:...|.|:..|:||....|.|||.||:.::....|:|:...|.:::
  Rat   163 LEDHSGNGTFVNTELIGKGKRCPLSNNSEIALSLCRNKVFVFFDLTVDDQSVYPKELRDEYIMSK 227

  Fly   179 KLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSD-PDRVLNEAKIMKNLSHPCVVR 242
            .|||||.|.|::.::.:||::.|:||:.|...  |..|:..:| ...|..|.:|:|.|:|||:::
  Rat   228 TLGSGACGEVKMAFERKTCKKVAIKIISKRRF--ALGSSREADTAPSVETEIEILKKLNHPCIIK 290

  Fly   243 MHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPD 307
            :.|:.|..| .|:|||.|.||:|.:|::.||.|.|...|||||||..||:|||:.||.||||||:
  Rat   291 IKDVFDVED-YYIVLELMEGGELFDRVVGNKRLKEATCKLYFYQMLLAVQYLHENGIIHRDLKPE 354

  Fly   308 NVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTKKVDIWSLGVV 372
            ||||.:.:|:.|:|::|||.||.:.:.|:||||||||.|:||||||:.|...|::.||.|||||:
  Rat   355 NVLLSSQEEDCLIKITDFGQSKILGETSLMRTLCGTPTYLAPEVLISNGTAGYSRAVDCWSLGVI 419

  Fly   373 LFTCLSGTLPFSDEYGTPAA--QQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSIDDV 435
            ||.||||..||| |:.|..:  .||..|::......|..||::|..|:.::|:|||:.|.:.::.
  Rat   420 LFICLSGYPPFS-EHKTQVSLKDQITSGKYNLIPEVWTDVSEKALDLVKKLLVVDPKARLTTEEA 483

  Fly   436 LQSSWLRDAPMLQKAKRLMKLDGMEIEEENFLEPP 470
            |...||:|..|.:|.:.|:      ::|:|.:..|
  Rat   484 LSHPWLQDEHMKKKFQDLL------VQEKNLVPLP 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	40/126 (32%)
		STKc_Chk2	167..441	CDD:270986	125/276 (45%)
		S_TKc	174..441	CDD:214567	123/269 (46%)
Chek2	NP_446129.1	FHA	96..204	CDD:238017	42/132 (32%)
Chek2	NP_446129.1	STKc_Chk2	216..489	CDD:270986	125/276 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166346516
Domainoid	1	1.000	243	1.000	Domainoid score	I2153
eggNOG	1	0.900	-	-		E1_KOG0615
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38289
Inparanoid	1	1.050	300	1.000	Inparanoid score	I2614
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1510589at2759
OrthoFinder	1	1.000	-	-		FOG0002433
OrthoInspector	1	1.000	-	-		oto95880
orthoMCL	1	0.900	-	-		OOG6_101842
Panther	1	1.100	-	-	LDO	PTHR44167
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1619
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.760