DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment lok and CHEK2

DIOPT Version :9

Sequence 1:NP_477219.1 Gene:lok / 35288 FlyBaseID:FBgn0019686 Length:476 Species:Drosophila melanogaster
Sequence 2:XP_011528141.1 Gene:CHEK2 / 11200 HGNCID:16627 Length:596 Species:Homo sapiens


Alignment Length:534 Identity:188/534 - (35%)
Similarity:282/534 - (52%) Gaps:79/534 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 ARDTQGTQGTQSQASNIWTQ-----------VESQPME--KIVWGRLYGKNIKIKSLGTSSKYRI 53
            ::.:..:.||.|....:.||           .:.:|.|  ...|.||:.......:|.|.|.:  
Human    60 SQSSHSSSGTLSSLETVSTQELYSIPEDQEPEDQEPEEPTPAPWARLWALQDGFANLETESGH-- 122

  Fly    54 IYTHSSFSVDLN-----------------------------NDEFTAGRGEANDLILTLNDLPEK 89
             .|.|...:.|:                             ||.:..||.::.:..     ..|.
Human   123 -VTQSDLELLLSSDPPASASQSAGIRGVRHHPRPVCSLKCVNDNYWFGRDKSCEYC-----FDEP 181

  Fly    90 ILTR------ISKVHF-IIKRANCELTNPVYIQDLSRNGTFVNNEKIGTNRMRILKNDDVISLSH 147
            :|.|      .||.|| |.:....:.:...||:|.|.||||||.|.:|..:.|.|.|:..|:||.
Human   182 LLKRTDKYRTYSKKHFRIFREVGPKNSYIAYIEDHSGNGTFVNTELVGKGKRRPLNNNSEIALSL 246

  Fly   148 PTYKAFVFKDLSPNESIGLPEEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSG 212
            ...|.|||.||:.::....|:.:...|.:::.|||||.|.|:|.::.:||::.|:||:.|...  
Human   247 SRNKVFVFFDLTVDDQSVYPKALRDEYIMSKTLGSGACGEVKLAFERKTCKKVAIKIISKRKF-- 309

  Fly   213 ARPSTNFSDPD-RVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLS 276
            |..|...:||. .|..|.:|:|.|:|||::::.:..|..| .|:|||.|.||:|.::::.||.|.
Human   310 AIGSAREADPALNVETEIEILKKLNHPCIIKIKNFFDAED-YYIVLELMEGGELFDKVVGNKRLK 373

  Fly   277 EDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLC 341
            |...|||||||..||:|||:.||.||||||:||||.:.:|:.|:|::|||.||.:.:.|:|||||
Human   374 EATCKLYFYQMLLAVQYLHENGIIHRDLKPENVLLSSQEEDCLIKITDFGHSKILGETSLMRTLC 438

  Fly   342 GTPLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAA--QQIKKGRFAYGH 404
            |||.|:|||||::.|...|.:.||.|||||:||.||||..||| |:.|..:  .||..|::.:..
Human   439 GTPTYLAPEVLVSVGTAGYNRAVDCWSLGVILFICLSGYPPFS-EHRTQVSLKDQITSGKYNFIP 502

  Fly   405 PSWKSVSQRAKLLINQMLIVDPERRPSIDDVLQSSWLRDAPMLQKAKRLMKLDGMEIEEEN---- 465
            ..|..||::|..|:.::|:|||:.|.:.::.|:..||:|..|.:|.:.|       :.|||    
Human   503 EVWAEVSEKALDLVKKLLVVDPKARFTTEEALRHPWLQDEDMKRKFQDL-------LSEENESTA 560

  Fly   466 ----FLEPPTKRSR 475
                ..:|.|.|.|
Human   561 LPQVLAQPSTSRKR 574

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lokNP_477219.1 FHA 39..156 CDD:238017 39/152 (26%)
STKc_Chk2 167..441 CDD:270986 123/276 (45%)
S_TKc 174..441 CDD:214567 122/269 (45%)
CHEK2XP_011528141.1 FHA <166..254 CDD:238017 30/92 (33%)
STKc_Chk2 266..539 CDD:270986 123/276 (45%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165152927
Domainoid 1 1.000 241 1.000 Domainoid score I2247
eggNOG 1 0.900 - - E1_KOG0615
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H38289
Inparanoid 1 1.050 297 1.000 Inparanoid score I2740
Isobase 1 0.950 - 0 Normalized mean entropy S1885
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D1510589at2759
OrthoFinder 1 1.000 - - FOG0002433
OrthoInspector 1 1.000 - - oto88745
orthoMCL 1 0.900 - - OOG6_101842
Panther 1 1.100 - - LDO PTHR44167
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2971
SonicParanoid 1 1.000 - - X1619
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.740

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