Protein Alignment lok and TLK2

DIOPT Version :9

• Sequence 1: NP_477219.1
• Gene: lok / 35288
• FlyBaseID: FBgn0019686
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: XP_024306320.1
• Gene: TLK2 / 11011
• HGNCID: 11842
• Length: 779
• Species: Homo sapiens
• Alignment Length: 450
• Identity: 118/450 - (26%)
• Similarity: 188/450 - (41%)
• Gaps: 99/450 - (22%)

  Fly    38 KNIKIKSLGTSSKYRIIYTHSSFSVDLNNDEFTAGRGEANDLI-LTLNDLPEKILTRISKVHF-I 100
            |..|.|:.|..::     |.||.:.:|.:   ||....|:.|: |||.:..|:  ..|.|:.. .
Human   368 KQRKSKTNGAENE-----TPSSGNTELKD---TAPALGAHSLLRLTLAEYHEQ--EEIFKLRLGH 422

  Fly   101 IKRANCEL---------TNPVYIQDLSRNGTFVNNEKIGTNRMRILKNDDVISLSHPTYKAFVFK 156
            :|:...|:         ...::|::|.|    ::||            |:.....|||
Human   423 LKKEEAEIQAELERLERVRNLHIRELKR----IHNE------------DNSQFKDHPT------- 464

  Fly   157 DLSPNESIGLPEEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSD 221
                         :|..|.:...||.|.:..|...:|....:..|:||.:.|        .|:.|
Human   465 -------------LNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLN--------KNWRD 508

  Fly   222 PDR------VLNEAKIMKNLSHPCVVRMHDIVD-KPDSVYMVLEFMRGGDLLNRIISNKLLSEDI 279
            ..:      ...|.:|.|.|.||.:|:::|... ..||...|||:..|.||...:..:||:||..
Human   509 EKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKE 573

  Fly   280 SKLYFYQMCHAVKYLHD--RGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDS------- 335
            ::....|:.:|:|||::  ..|.|.||||.|:||........:|::||||||.:..||
Human   574 ARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGM 638

  Fly   336 -VMRTLCGTPLYVAPEVLITGGR-EAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQ---- 394
             :.....||..|:.||..:.|.. ...:.|||:||:||:.:.||.|..||    |...:||
Human   639 ELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPF----GHNQSQQDILQ 699

  Fly   395 ----IKKGRFAYGHPSWKSVSQRAKLLINQMLIVDPERRPSIDDVLQSSWLRDAPMLQKA 450
                :|.....:  |....|:..||..|.:.|....|.|..:..:....:|  .|.::|:
Human   700 ENTILKATEVQF--PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL--LPHIRKS 755

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	28/127 (22%)
		STKc_Chk2	167..441	CDD:270986	86/299 (29%)
		S_TKc	174..441	CDD:214567	85/292 (29%)
TLK2	XP_024306320.1	SMC_N	<209..>444	CDD:330553	20/85 (24%)
		STKc_TLK2	462..770	CDD:270943	92/329 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910