DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and PAK4

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	NP_001014831.1	Gene:	PAK4 / 10298	HGNCID:	16059	Length:	591	Species:	Homo sapiens

Alignment Length:	311	Identity:	89/311 - (28%)
Similarity:	156/311 - (50%)	Gaps:	39/311 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 LSHPTYKAFVFKDLSPNESIGLPEEINKTYYVN-RKLGSGAYGLVRLVYDTRTCQQFAMKIVKKN 208
            :||..::|.:...:.|.:.        ::|..| .|:|.|:.|:|.:.....:.:..|:|  |.:
Human   299 VSHEQFRAALQLVVDPGDP--------RSYLDNFIKIGEGSTGIVCIATVRSSGKLVAVK--KMD 353

  Fly   209 MLSGARPSTNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNK 273
            :....|....|       ||..||::..|..||.|::.....|.:::|:||:.||.|.:.:...:
Human   354 LRKQQRRELLF-------NEVVIMRDYQHENVVEMYNSYLVGDELWVVMEFLEGGALTDIVTHTR 411

  Fly   274 LLSEDISKLYFYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMR 338
            :..|.|:.:.. .:..|:..||.:|:.|||:|.|::|| |:|..  :|:||||....|.|:...|
Human   412 MNEEQIAAVCL-AVLQALSVLHAQGVIHRDIKSDSILL-THDGR--VKLSDFGFCAQVSKEVPRR 472

  Fly   339 -TLCGTPLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKG---R 399
             :|.|||.::|||::   .|..|..:|||||||:::...:.|..|:.:|....|.:.|:..   |
Human   473 KSLVGTPYWMAPELI---SRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRDNLPPR 534

  Fly   400 FAYGHPSWKSVSQRAKLLINQMLIVDPERRPSIDDVLQSSWLRDAPMLQKA 450
            ....|    .||...|..::::|:.||.:|.:..::|:.      |.|.||
Human   535 LKNLH----KVSPSLKGFLDRLLVRDPAQRATAAELLKH------PFLAKA 575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	3/10 (30%)
		STKc_Chk2	167..441	CDD:270986	81/278 (29%)
		S_TKc	174..441	CDD:214567	81/271 (30%)
PAK4	NP_001014831.1	CRIB_PAK_like	10..55	CDD:238526
		Linker	25..320		4/28 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	95..301		0/1 (0%)
		GEF-interaction domain (GID)	298..323		5/31 (16%)
		STKc_PAK4	300..591	CDD:132988	89/310 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910