DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and ephb4

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_031755496.1	Gene:	ephb4 / 100497297	XenbaseID:	XB-GENE-5881604	Length:	945	Species:	Xenopus tropicalis

Alignment Length:	354	Identity:	84/354 - (23%)
Similarity:	144/354 - (40%)	Gaps:	86/354 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 FVFKDLSPNESI-GLPEEIN-KTYYVNRKLGSGAYGLV---RLVYDTRTCQQFAMKIVKKNMLSG 212
            |.::|  |||:: ...:||: ....:...:|:|.:|.|   ||....:.....|:|.:|......
Frog   594 FTYED--PNEAVREFAKEIDVSCVKIEEVIGAGEFGEVCRGRLKVPGKKENYVAIKTLKGGYTER 656

  Fly   213 ARPSTNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSE 277
            .|        ...|:||.||...:||.::.:..::.....|.::.|:|..|.|      :..|.:
Frog   657 QR--------REFLSEASIMGQFNHPNIIHLEGVITNNCPVMIITEYMENGAL------DSFLRQ 707

  Fly   278 DISKLYFYQM-------CHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDS 335
            :..:....|:       ...::||.:....||||...|:|:.:|   .:.||||||||:|:|:.|
Frog   708 NDGQFTPIQLVGMLRGIASGMRYLAEMNYVHRDLAARNILVNSN---LVCKVSDFGLSRFLQEGS 769

  Fly   336 VMRTLCG-----TPL-YVAPEVLITGGREAYTKKVDIWSLGVVLFTCLS-GTLPFSD-------- 385
            ...|...     .|: :.|||.:   ....:|...|:|..|:|::..:| |..|:.|
Frog   770 TDPTYTSCLGGKIPIRWTAPEAI---AFRKFTSASDVWGYGIVMWEVMSFGERPYWDMSNQDVIN 831

  Fly   386 ----EYGTPA-----------------AQQIKKGRFA---------YGHPSWKSVSQRAKLLINQ 420
                :|..||                 ..:..:.|||         ..:|:...::.|.:|..:|
Frog   832 AIEQDYRLPAPPDCPTALHQLMLDCWQRDRALRPRFADIVSSLDKLIRNPASLKITTREQLGTSQ 896

  Fly   421 MLIVDPERRP---SIDDVLQSSWLRDAPM 446
            .|:  .:|.|   |...|  |.||:...|
Frog   897 PLL--DQRTPHYSSFSSV--SEWLQAIKM 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	1/2 (50%)
		STKc_Chk2	167..441	CDD:270986	76/332 (23%)
		S_TKc	174..441	CDD:214567	74/324 (23%)
ephb4	XP_031755496.1	EphR_LBD_B4	17..196	CDD:198442
		fn3	325..417	CDD:394996
		fn3	435..520	CDD:394996
		EphA2_TM	541..612	CDD:405290	7/19 (37%)
		PTKc_EphR_B	610..878	CDD:173638	65/287 (23%)
		SAM_superfamily	907..>945	CDD:417767	6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910