DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and LOC100494929

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_004917824.1	Gene:	LOC100494929 / 100494929	-ID:	-	Length:	1019	Species:	Xenopus tropicalis

Alignment Length:	499	Identity:	111/499 - (22%)
Similarity:	186/499 - (37%)	Gaps:	104/499 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 TQVESQPMEKIVWGRLYGKNIKIKSLGTSSKYRIIYTHSSFSVDLNNDEFTAGRGEANDLILTLN 84
            |:..|..::.:..|.:|...::..:||....|     .....::.:.::..|.....:..||.::
Frog   501 TRSSSMTVDGLKPGTIYIFKVRAHTLGGQGVY-----GGEIELETSTEDMVAIADAGHITILAIS 560

  Fly    85 DLPEKILTRISKVHFIIK-----RANCELTNPVYIQDLSRNGTFVNNEKIGTNRMRILKNDDVIS 144
            .....||.......|.:.     ..:|..:||.:.......|........|..:.:...::|.:.
Frog   561 AAGGLILLIFLVTCFFLSGRSVYTRSCCGSNPPHPDPKKNRGYAPLMIHCGYIKAKQDPDEDKMQ 625

  Fly   145 LSH-----PTYKAFV----FKDLSPNESI-GLPEEIN-KTYYVNRKLGSGAYGLV-----RLVYD 193
            ..|     |..|.::    ::|  ||::: ...:||: ....:.|.:|:|.:|.|     ||...
Frog   626 FQHGRVKLPGSKTYIHPHTYED--PNQAVRDFAKEIDASAIRIERVIGAGEFGEVCSGRLRLPSK 688

  Fly   194 TRTCQQFAMKIVKKNMLSGARPSTNFSDPDR--VLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMV 256
            ...|  .|:|.:|          ..:|:..|  .|.||.||....||.::|:..:|.|...|.::
Frog   689 REIC--VAIKSLK----------AGYSEKQRRDFLGEASIMGQFDHPNIIRLEGVVTKCKPVMII 741

  Fly   257 LEFMRGGDLLNRIISNKLLSEDISKLYFYQM-------CHAVKYLHDRGITHRDLKPDNVLLETN 314
            .|||..|.|      :..|.:...:....|:       ...:|||.|....||||...|:|:.:|
Frog   742 TEFMENGSL------DTFLKKHDGQFTVIQLVGMLRGIASGMKYLSDMNYVHRDLAARNILVNSN 800

  Fly   315 DEETLLKVSDFGLSKFVQKD--SVMRTLCG-TPL-YVAPEVLITGGREAYTKKVDIWSLGVVLFT 375
               .:.||||||||:.::.|  :...|..| .|: :.|||.:   ....:|...|:||.|:|::.
Frog   801 ---LVCKVSDFGLSRVLEDDPEAAYTTRGGKIPIRWTAPEAI---AYRKFTSASDVWSYGIVMWE 859

  Fly   376 CLS-GTLPFSDEYGTPAAQQIKKGRFAYGHP---------------SW-KSVSQRAKL------- 416
            .:| |..|:.:.......:.|.:|   |..|               .| |..|.|.|.
Frog   860 VISYGERPYWEMSNQDVIKAIDEG---YRLPPPMDCPVVLHQLMLDCWQKCRSDRPKFGQIVNVL 921

  Fly   417 ------------LINQMLIVDPERRPSIDDVLQSSWLRDAPMLQ 448
                        |.|.....||....|:.......||....|.|
Frog   922 DKYIRTPSSLNELANSSTWQDPSMHDSMPVTTVEQWLEAIKMSQ 965

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	18/130 (14%)
		STKc_Chk2	167..441	CDD:270986	82/328 (25%)
		S_TKc	174..441	CDD:214567	80/320 (25%)
LOC100494929	XP_004917824.1	EphR_LBD_A	46..217	CDD:198441
		FN3	342..448	CDD:238020
		FN3	449..540	CDD:238020	7/43 (16%)
		EphA2_TM	560..659	CDD:373140	15/100 (15%)
		PTKc_EphR_A	659..925	CDD:270651	76/292 (26%)
		SAM_EPH-R	950..1010	CDD:188887	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910