DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and dclk2

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_012811056.1	Gene:	dclk2 / 100487296	XenbaseID:	XB-GENE-960488	Length:	727	Species:	Xenopus tropicalis

Alignment Length:	297	Identity:	96/297 - (32%)
Similarity:	155/297 - (52%)	Gaps:	27/297 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   161 NESIGLPEEIN-----------KTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGAR 214
            |..:..||.:|           :.|.:.:.:|.|.:.:|:...:..|.::||:||:.|....|..
Frog   374 NGLLNSPEGLNGNKFTDASIILEKYKIGKVIGDGNFAVVKECVERSTGKEFALKIIDKAKCCGKE 438

  Fly   215 PSTNFSDPDRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDI 279
                    ..:.||..|::.:.||.::.:.:.:|....:|:|:|.::||||.:.|.|:...:|..
Frog   439 --------HLIENEVSILRQVKHPNIIMLIEEMDTTAELYLVMELVKGGDLFDAITSSTKYTERD 495

  Fly   280 SKLYFYQMCHAVKYLHDRGITHRDLKPDNVLL-ETNDEETLLKVSDFGLSKFVQKDSVMRTLCGT 343
            :....|.:..|:||||...|.|||:||:|:|: |..|:...||:.||||:..|  |..:.|:|||
Frog   496 ASAMVYNLASAMKYLHGLHIVHRDIKPENLLVCEYPDKTKSLKLGDFGLATVV--DGPLYTVCGT 558

  Fly   344 PLYVAPEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYG--TPAAQQIKKGRFAYGHPS 406
            |.|||||::...|   |..|||||:.||:.:..|.|..||..|..  .....||..|:..:..|.
Frog   559 PTYVAPEIIAETG---YGLKVDIWAAGVITYILLCGFPPFRSENNLQEDLFDQILIGKLEFPSPY 620

  Fly   407 WKSVSQRAKLLINQMLIVDPERRPSIDDVLQSSWLRD 443
            |.:::..||.||:.||.|:.|.|.:.:.:|...|:.|
Frog   621 WDNITDSAKELISCMLQVNVEERYTAEQILSHPWVSD 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	93/287 (32%)
		S_TKc	174..441	CDD:214567	90/269 (33%)
dclk2	XP_012811056.1	DCX1_DCLK2	70..154	CDD:340661
		DCX2	193..276	CDD:340589
		STKc_DCKL2	396..654	CDD:271086	90/270 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000