DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment lok and chek2

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_031750712.1	Gene:	chek2 / 100144952	XenbaseID:	XB-GENE-5765421	Length:	516	Species:	Xenopus tropicalis

Alignment Length:	515	Identity:	196/515 - (38%)
Similarity:	292/515 - (56%)	Gaps:	77/515 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MARDT----QGTQGT------------QSQASNIWTQVESQPMEKIV---------------WGR 34
            |:|||    |.:|||            ||.:|...:.:|:.|::.:.               |||
Frog     2 MSRDTKTESQQSQGTSSSSSSAPQSYSQSSSSGTLSSLETVPVQDLASIPKDPEIDEDIPQPWGR 66

  Fly    35 LYGKNIKIKSLGTSSKYRIIYTHSSFSVDLNND----EFTAGRGEANDLILTLNDLP-----EKI 90
            |:       :||...              ||:|    |:..||.:..|...   |:|     |:.
Frog    67 LW-------ALGRGF--------------LNHDCLLEEYVFGRDKKCDYTF---DIPVINQTERY 107

  Fly    91 LTRISKVHFIIKRANCELTNPV-YIQDLSRNGTFVNNEKIGTNRMRILKNDDVISLSHPTYKAFV 154
            .| .||.||.|.|......:|| ||:|||.||||||.|.||..:...|.|:..|:||..:.|.||
Frog   108 KT-YSKRHFRIFREFGHGHSPVAYIEDLSGNGTFVNKEIIGRGKKLPLTNNAEIALSLSSNKVFV 171

  Fly   155 FKDLSPNESIGLPEEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNF 219
            |.|||.::....|::.:..|.::|.:||||.|.|:|.:....|::.|:||:.|...   :.||:.
Frog   172 FSDLSVDDQTIYPKDFSDKYIMSRPIGSGACGEVKLAFQKSACKKVAVKIISKRKF---KMSTSS 233

  Fly   220 SD-PDRVLNEAKIMKNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLY 283
            :: |..|..|.:|:|.:.|||::::.:..|..|..|:|||.|.||:|.::::|:..|.|..:|||
Frog   234 NEHPISVDTEIEILKKIDHPCIIKIENFFDSEDFFYIVLELMEGGELFDKVVSSTRLRESTAKLY 298

  Fly   284 FYQMCHAVKYLHDRGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVA 348
            ||||..||:|||:.|:.||||||:||||.:::||..:|::|||.||.:.:.|:||||||||.|:|
Frog   299 FYQMLLAVQYLHENGVIHRDLKPENVLLSSSNEECCIKITDFGQSKILGETSLMRTLCGTPTYLA 363

  Fly   349 PEVLITGGREAYTKKVDIWSLGVVLFTCLSGTLPFSDEYG-TPAAQQIKKGRFAYGHPSWKSVSQ 412
            ||||.|.|...|::.||.|||||:||.||||..|||::.. .|...||.:|::.|...:|.:||:
Frog   364 PEVLNTAGTTGYSRAVDYWSLGVILFVCLSGYPPFSEQNSKIPLKNQIAEGKYTYIPAAWDAVSE 428

  Fly   413 RAKLLINQMLIVDPERRPSIDDVLQSSWLRDAPMLQKAKRLMKLDGMEIEEENFLEPPTK 472
            :|..|:.::|:||||:|.:....|:..||:|..|...|:|||.  |:    ::.:.||:|
Frog   429 QALDLVKKLLVVDPEQRLTTKQALEHPWLQDDDMKHTAERLMY--GV----DHTMPPPSK 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017	43/126 (34%)
		STKc_Chk2	167..441	CDD:270986	120/275 (44%)
		S_TKc	174..441	CDD:214567	119/268 (44%)
chek2	XP_031750712.1	FHA	64..173	CDD:238017	47/133 (35%)
chek2	XP_031750712.1	STKc_Chk2	184..457	CDD:270986	120/275 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	249	1.000	Domainoid score	I2089
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H38289
Inparanoid	1	1.050	309	1.000	Inparanoid score	I2562
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1510589at2759
OrthoFinder	1	1.000	-	-		FOG0002433
OrthoInspector	1	1.000	-	-		oto102615
Panther	1	1.100	-	-	LDO	PTHR44167
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1619
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	11.070