DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lok and SBK3

DIOPT Version :9

Sequence 1:	NP_477219.1	Gene:	lok / 35288	FlyBaseID:	FBgn0019686	Length:	476	Species:	Drosophila melanogaster
Sequence 2:	XP_011524600.1	Gene:	SBK3 / 100130827	HGNCID:	44121	Length:	384	Species:	Homo sapiens

Alignment Length:	279	Identity:	71/279 - (25%)
Similarity:	122/279 - (43%)	Gaps:	25/279 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   174 YYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKNLSHP 238
            |::.||||||:||.|.|....:.....|:|:::::::..:.....|.....|.....:::.|:.|
Human    68 YHLIRKLGSGSYGRVLLAQPHQGGPAVALKLLRRDLVLRSTFLREFCVGRCVSAHPGLLQTLAGP 132

  Fly   239 CVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGITHRD 303
                    :..|.......|:...|| |:.::..:.|.|.:.|....|:..|:.:||.||:.|.|
Human   133 --------LQTPRYFAFAQEYAPCGD-LSGMLQERGLPELLVKRVVAQLAGALDFLHSRGLVHAD 188

  Fly   304 LKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPE---VLITGGREAYTKKVD 365
            :||||||: .:...:.:.:.|.||::   .:.........||..||.   :|:..........||
Human   189 VKPDNVLV-FDPVCSRVALGDLGLTR---PEGSPTPAPPVPLPTAPPELCLLLPPDTLPLRPAVD 249

  Fly   366 IWSLGVVLFTCLSGTLPF------SDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIV 424
            .|.|||:||...:...|:      :.|:...|.....|.:.....|.|...:..|..|:..:|.:
Human   250 SWGLGVLLFCAATACFPWDVALAPNPEFEAFAGWVTTKPQPPQPPPPWDQFAPPALALLQGLLDL 314

  Fly   425 DPERRP---SIDDVLQSSW 440
            |||.|.   ::.|.|...|
Human   315 DPETRSPPLAVLDFLGDDW 333

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA	39..156	CDD:238017
		STKc_Chk2	167..441	CDD:270986	71/279 (25%)
		S_TKc	174..441	CDD:214567	71/279 (25%)
SBK3	XP_011524600.1	PKc_like	74..333	CDD:304357	67/271 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910