Protein Alignment barr and BRN1

DIOPT Version :10

• Sequence 1: NP_477106.1
• Gene: barr / 35287
• FlyBaseID: FBgn0014127
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_009455.3
• Gene: BRN1 / 852180
• SGDID: S000000193
• Length: 754
• Species: Saccharomyces cerevisiae
• Alignment Length: 834
• Identity: 171/834 - (20%)
• Similarity: 291/834 - (34%)
• Gaps: 239/834 - (28%)

  Fly    30 NDDEAERREARRRTLLQQHHRSSTLESIEDNETIKNCLELYNGNKVSKDNAWNLMLID---SLAN 91
            |:|:.||.|....|     :||:.:.:.|:      .:::...||::..|:||..|||   .|..
Yeast     9 NNDDDERVEYNLFT-----NRSTMMANFEE------WIKMATDNKINSRNSWNFALIDYFYDLDV 62

  Fly    92 LLDHHHKRMSNFKMAGSSLEASSKVYGLRVDSIYLDAMRISAGLSARTLTDKQINAAEDDDGPQG 156
            |.|..:.  .||:.|.::|:...|:|..||||:..:..::.:||:.|     :.|.|.:.|...|
Yeast    63 LKDGENN--INFQKASATLDGCIKIYSSRVDSVTTETGKLLSGLAQR-----KTNGASNGDDSNG 120

  Fly   157 EQATGEGQDSAQQAAKEAAP---------------KPKRQKKPISTVTKNRETLNSR-LDTAPLQ 205
            ....|.|.|| .:|..|..|               :.:...:.:.|.....||:..: ||...:.
Yeast   121 GNGEGLGGDS-DEANIEIDPLTGMPISNDPDVNNTRRRVYNRVLETTLVEFETIKMKELDQELII 184

  Fly   206 DPVFGKLNSTVGSINASNRLMHNILPSFDSELR------LRTTYNFWNS--EESTEEVQDHTTLN 262
            ||:|.|.........|.:.|::.:  :.|:..|      ::.|.|....  :...||:.:..:|
Yeast   185 DPLFKKALVDFDEGGAKSLLLNTL--NIDNTARVIFDASIKDTQNVGQGKLQRKEEELIERDSL- 246

  Fly   263 AEMEQWPATSLMSTNLMRKLLPHAERSNLRPLHTGYIITSAPNPKSANEK--AAEVVQDEDHDEG 325
            .:.|..|:.||:||.                           |..:.|:.  :|..::||....|
Yeast   247 VDDENEPSQSLISTR---------------------------NDSTVNDSVISAPSMEDEILSLG 284

  Fly   326 LD--NADDMCVNEIS--------MAFDINAECEPMPDLDGPPPLVLEVDSNELEELTAEEQM--- 377
            :|  ..|.:.|.|||        :..|||...:           .:|..:|..:....||::
Yeast   285 MDFIKFDQIAVCEISGSIEQLRNVVEDINQAKD-----------FIENVNNRFDNFLTEEELQAA 338

  Fly   378 VINN----------------CRRLRKQTEFIEDLRPVDGNSKLEYSYRPMDQISQF-------WA 419
            |.:|                |...........|.:..|..:....|....|.::.|       |.
Yeast   339 VPDNAEDDSDGFDMGMQQELCYPDENHDNTSHDEQDDDNVNSTTGSIFEKDLMAYFDENLNRNWR 403

  Fly   420 GPSHWK---FKRT-----------RPRSTFSQTNGQ--VDTQPIRTQRAKKSAHLNANRRAKALD 468
            |..|||   ||:.           ..|:|...|..:  .|.:.:.|::..|      .::...:|
Yeast   404 GREHWKVRNFKKANLVNKESDLLEETRTTIGDTTDKNTTDDKSMDTKKKHK------QKKVLEID 462

  Fly   469 YGNVTENFFQ---------QLDTTIRQRKANFQKKWDPRKLILPTKFELDPD----LFFKYESAP 520
            :....::|..         ::|..|:.||       :....:||..|....|    ||.|    |
Yeast   463 FFKTDDSFEDKVFASKGRTKIDMPIKNRK-------NDTHYLLPDDFHFSTDRITRLFIK----P 516

  Fly   521 SIKLS--KRAGEPDSDEGGDLGIDMDADMHHDDDNDQELFNNEHFTDAVPANVSVIAAIAAEQAA 583
            ..|:|  ........|....|........:| .:||.....:|||.           |...|:..
Yeast   517 GQKMSLFSHRKHTRGDVSSGLFEKSTVSANH-SNNDIPTIADEHFW-----------ADNYERKE 569

  Fly   584 EASMMNVSAGEIGLTQMNATCN-----------NTVFEIGTEFEGAPS-------------QVAK 624
            :.......:.|:|.....|..|           |..|| ||:.....|             .:.:
Yeast   570 QEEKEKEQSKEVGDVVGGALDNPFEDDMDGVDFNQAFE-GTDDNEEASVKLDLQDDEDHKFPIRE 633

  Fly   625 VIVPFAKRAKVIDMKNLKK----SCNSLIQKQLLNAVPEETIPSHPKKKGEHYSKGFA------- 678
            ..|.:::.:|.:|::.|||    |.|:|||:             |..:|....|...:
Yeast   634 NKVTYSRVSKKVDVRRLKKNVWRSINNLIQE-------------HDSRKNREQSSNDSETHTEDE 685

  Fly   679 -----SFQQVYQKLPDLLTTKMSDSLSPSVAFYAVLHLANDLKLRLIPQEDLED 727
                 .|..:.|.:..:.:......:|.|..|..:|||||:..|::...|:..|
Yeast   686 STKELKFSDIIQGISKMYSDDTLKDISTSFCFICLLHLANEHGLQITHTENYND 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
barr	NP_477106.1	Cnd2	7..732	CDD:428627	171/834 (21%)
BRN1	NP_009455.3	LOC7	27..754	CDD:227554	163/811 (20%)