DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment barr and ncaph

DIOPT Version :9

Sequence 1:	NP_001286094.1	Gene:	barr / 35287	FlyBaseID:	FBgn0014127	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_001073665.1	Gene:	ncaph / 570062	ZFINID:	ZDB-GENE-070112-652	Length:	690	Species:	Danio rerio

Alignment Length:	819	Identity:	203/819 - (24%)
Similarity:	314/819 - (38%)	Gaps:	230/819 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TPLRRS------AVGSYQEGVSRMLTPF------NDDEAERREARRRTLLQQH------------ 48
            ||..|.      |:| ::..:|...||.      ||||.|||:.||..::..|
Zfish     6 TPTARQRQWSSPALG-HKAALSTTSTPLLDNIQGNDDEQERRQRRRSRVIDLHGVNDSSINEAGT 69

  Fly    49 HRSS-------TLESIEDNETIKNCLELYNGNKVSKDNAWNLMLIDSLANLLDHHHKRMSNFKMA 106
            |.|:       .|.|.:.:|....|::|...||::..||:.|.|||.:|::|......: |||:|
Zfish    70 HSSAGTPAAVPKLSSAQISEHYSTCIKLSTENKITTKNAFGLHLIDYMADILKEKDSEL-NFKVA 133

  Fly   107 GSSLEASSKVYGLRVDSIYLDAMRISAGLSARTLTDKQINAAEDDDGPQGEQATGEGQDSAQQAA 171
            ..:|:||:|:|.:|||:::.||.|:..||.:.|      ...|..|| ..|....||....|.||
Zfish   134 AGTLDASTKIYAVRVDAVHADAYRVLGGLGSET------KPKESQDG-DDETEAAEGSQGEQVAA 191

  Fly   172 KEAAPKPKRQKKPISTVTKNRETLNSRLDTAPLQ---DPVFGKL------NSTVGSINASNRLMH 227
            |:...:|     |..||.:|...:|  |..:.::   ||:|.::      |||.|       :..
Zfish   192 KQTKKRP-----PKKTVEQNLSNIN--LSESEMKCEVDPMFQRMAASFDENSTAG-------VFL 242

  Fly   228 NILPSFDS--ELRLRTTYNFWNSEESTEEVQDHTTLNAEMEQWPATSLMSTNLMRKLLPHAERSN 290
            ::|.|.||  |||..:......|:....:| .|..:.|.    |.|..:.|...|.:.|..|
Zfish   243 SVLFSEDSCCELRFPSHMTLLKSQLPPVQV-SHQNVPAS----PFTGHLKTLEDRPICPSLE--- 299

  Fly   291 LRPLHTGYIITS-APNPKSANEKAAEVVQDEDHDEGLDNADDMCVNEISMAFDINAECEP----M 350
                  .:..|. .|...:...:..|.::..:|                 |||:||:.||    .
Zfish   300 ------DFSFTRWTPEQTTNLNQLLEKMKQGEH-----------------AFDVNADIEPDEDDA 341

  Fly   351 PDL---------DGPPPLVLEVDSNELEE---------------LTAEEQMVINNCRRLRKQTEF 391
            ||.         :|.|.     |:.|.:|               :...|..:...|.:|..|..
Zfish   342 PDFGDNFDADVDEGRPG-----DNEEFKEHKEACSKSPQNGRGVIPIGEVDIATMCLQLSDQPR- 400

  Fly   392 IEDLRPVDGNSKLEYSY---RPMDQISQFWAGPSHWKFKRTRPRSTFSQTNGQVDTQPIRTQRAK 453
                         ||||   |.|    ..|.||.:|.||....:.                |:..
Zfish   401 -------------EYSYFSPRTM----ATWVGPGYWLFKPGHKQD----------------QKPD 432

  Fly   454 KSAHLNANRRAKALDY-GNVT-ENFFQ--QLDTTIRQRKANFQKKWDPRKLILPTKFELDPDLFF 514
            |.....|.:....:|: .::. .|:|:  :..|||.:...|...|    |..||..|:..|....
Zfish   433 KEPRKRAPKNPLIIDFKADINFHNYFKTTRAATTISKSALNTSNK----KTTLPADFQYPPSNLS 493

  Fly   515 KYESAPSIKLS----KR-AGEPDSDEGGDLGIDMDADMHHDDDNDQELFNNEHFTDAVPANVSVI 574
            :....||..||    || :||...|.|           .:|       :||.:.|    ||....
Zfish   494 QLNLKPSNTLSAEGKKRLSGELSEDIG-----------EYD-------YNNANDT----ANFCPG 536

  Fly   575 AAIAAEQAAEASMMNVSAGEIGLTQMNATCNNTVFEIGTE---------FEGAPSQVAKVIVPFA 630
            ......:.||.         .|.:..:.|...|.|.:.|:         ....|.::..:.:.:|
Zfish   537 LQEGDSEDAEG---------FGGSDNSQTDRPTPFSLDTDDISTYGEDCLVPEPHKLNIIEINYA 592

  Fly   631 KRAKVIDMKNLKKSCNSLIQKQLLNAVPEETIPSHPKKKGEHYSK--GFASFQQVYQKLPDLLTT 693
            :.||.:|||.||.:...|:.:.     ||:|.   .:.:.|..::  |..||.|..:.|...|.:
Zfish   593 RTAKKMDMKKLKTTMWGLLTES-----PEKTA---KQVESEDTTEVPGEKSFSQSIRNLVQRLPS 649

  Fly   694 KMSDSLSPSVAFYAVLHLANDLKLRLIPQEDLEDFQIRQ 732
            .|:.:||..:||.|:|||||:..|.|...:.:.|..|:|
Zfish   650 AMATNLSVPLAFVALLHLANEKNLELHKIDGMTDIIIKQ 688

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
barr	NP_001286094.1	Cnd2	7..731	CDD:283450	201/816 (25%)
ncaph	NP_001073665.1	Cnd2	26..687	CDD:283450	196/795 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596566
Domainoid	1	1.000	128	1.000	Domainoid score	I5282
eggNOG	1	0.900	-	-		E1_COG5229
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133986
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4650
OMA	1	1.010	-	-		QHG55639
OrthoDB	1	1.010	-	-		D159113at33208
OrthoFinder	1	1.000	-	-		FOG0004936
OrthoInspector	1	1.000	-	-		oto38651
orthoMCL	1	0.900	-	-		OOG6_103100
Panther	1	1.100	-	-	LDO	PTHR13108
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3476
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	15	14.770