Protein Alignment barr and NCAPH

DIOPT Version :10

• Sequence 1: NP_477106.1
• Gene: barr / 35287
• FlyBaseID: FBgn0014127
• Length: 735
• Species: Drosophila melanogaster
• Sequence 2: NP_056156.2
• Gene: NCAPH / 23397
• HGNCID: 1112
• Length: 741
• Species: Homo sapiens
• Alignment Length: 816
• Identity: 195/816 - (23%)
• Similarity: 319/816 - (39%)
• Gaps: 196/816 - (24%)

  Fly     1 MTLPRLETPLRRSAVGSYQEGVSRMLTPFNDDEAERREARR-------------RTLLQQHHRSS 52
            |.||| :.||........::      .|.||||.||.:.||             |.|.....||.
Human    36 MPLPR-KAPLNIPGTPVLED------FPQNDDEKERLQRRRSRVFDLQFSTDSPRLLASPSSRSI 93

  Fly    53 TLE-------SIEDNETIKNCLELYNGNKVSKDNAWNLMLIDSLANLLDHHHKRMSNFKMAGSSL 110
            .:.       :.:..|....|::|...||::..||:.|.|||.::.:|.......:|||:|..:|
Human    94 DISATIPKFTNTQITEHYSTCIKLSTENKITTKNAFGLHLIDFMSEILKQKDTEPTNFKVAAGTL 158

  Fly   111 EASSKVYGLRVDSIYLDAMRISAGLSARTLTDKQINAAEDDDGPQGEQATGEGQD--SAQQAAKE 173
            :||:|:|.:|||:::.|..|:..||.              .|.|..|:..|...|  :.:....:
Human   159 DASTKIYAVRVDAVHADVYRVLGGLG--------------KDAPSLEEVEGHVADGSATEMGTTK 209

  Fly   174 AAPKPKRQKKPISTVTKNRETLN-SRLDTAPLQDPVFGKLNSTVGSINASNRLMHNI-LPSFDSE 236
            .|.|||: |....|:.:|...|| |..|.....||:|.|..::....:.:...:..: ...:.||
Human   210 KAVKPKK-KHLHRTIEQNINNLNVSEADRKCEIDPMFQKTAASFDECSTAGVFLSTLHCQDYRSE 273

  Fly   237 LRLRTTYNFWNSEESTEEVQ----DHTTLNAEMEQWPATSLMSTNLMRKLLPHAERSNLRPLHTG 297
            |...:.....::.|..|..:    :.|.|.|.::|.                 ||...:.|...|
Human   274 LLFPSDVQTLSTGEPLELPELGCVEMTDLKAPLQQC-----------------AEDRQICPSLAG 321

  Fly   298 YIITSAPNPKSANEKAAEVVQDEDHDEGLDNADDMCVNEISMAFDINAE-----CEPMPDLDGPP 357
            :..|.              ...|.|:|.:....|. ..:....||||||     |...||    .
Human   322 FQFTQ--------------WDSETHNESVSALVDK-FKKNDQVFDINAEVDESDCGDFPD----G 367

  Fly   358 PLVLEVDSNELEELTA----------EEQMVINNCRRLRKQTEFIE----DLR---PVDGNSKLE 405
            .|..:.|:|:..:.||          :|...:.:|     |.|.|.    |:|   |:......|
Human   368 SLGDDFDANDEPDHTAVGDHEEFRSWKEPCQVQSC-----QEEMISLGDGDIRTMCPLLSMKPGE 427

  Fly   406 YSY---RPMDQISQFWAGPSHWKFKRTRPRSTFSQTNGQVDTQPIRTQRAKKSAHLNAN------ 461
            |||   |.|    ..||||.||:|:..|.:...||:..       :.:..||...::..
Human   428 YSYFSPRTM----SMWAGPDHWRFRPRRKQDAPSQSEN-------KKKSTKKDFEIDFEDDIDFD 481

  Fly   462 ---RRAKALDYGNVTENFFQQLDTTIRQRKANFQKKWDPRKLILPTKFELDPDLFFKYESAPSIK 523
               |:.||               .||..:.....:.|  |...|||.|..:.|...:....|..:
Human   482 VYFRKTKA---------------ATILTKSTLENQNW--RATTLPTDFNYNVDTLVQLHLKPGTR 529

  Fly   524 LSKRAGEPDSDEGGDLGIDMDADMHHDDDNDQELFNNEHFTDAVPANVSVIAAIAAEQAAEASMM 588
            |.|.|          .|..::.: |:::..|.: :||.:.|.      :....:.|..:.:..:.
Human   530 LLKMA----------QGHRVETE-HYEEIEDYD-YNNPNDTS------NFCPGLQAADSDDEDLD 576

  Fly   589 NVSAGEIGLTQMNA-TCN--NTVFEIG--TEFEG-------------APSQVAKVIVPFAKRAKV 635
            ::..|.:|.:.::. .|:  .|..:.|  .|.:|             .|.:|.|:.:.:||.||.
Human   577 DLFVGPVGNSDLSPYPCHPPKTAQQNGDTPEAQGLDITTYGESNLVAEPQKVNKIEIHYAKTAKK 641

  Fly   636 IDMKNLKKSCNSLIQKQLLNAVPEETIPSHPKKKGEHYSKGFASFQQVYQKL-PDL---LTTKMS 696
            :|||.||:|..||:  ..|:....:...:| ::.|:..:....:.:::...| .||   |...|:
Human   642 MDMKKLKQSMWSLL--TALSGKEADAEANH-REAGKEAALAEVADEKMLSGLTKDLQRSLPPVMA 703

  Fly   697 DSLSPSVAFYAVLHLANDLKLRLIPQEDLEDFQIRQ 732
            .:||..:||..:|||||:..|:|...|||.|..:||
Human   704 QNLSIPLAFACLLHLANEKNLKLEGTEDLSDVLVRQ 739

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
barr	NP_477106.1	Cnd2	7..732	CDD:428627	189/808 (23%)
NCAPH	NP_056156.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..67		13/37 (35%)
		Cnd2	55..739	CDD:428627	187/788 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	361..383		6/25 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	447..467		4/26 (15%)