DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment barr and NCAPH

DIOPT Version :9

Sequence 1:	NP_001286094.1	Gene:	barr / 35287	FlyBaseID:	FBgn0014127	Length:	735	Species:	Drosophila melanogaster
Sequence 2:	NP_056156.2	Gene:	NCAPH / 23397	HGNCID:	1112	Length:	741	Species:	Homo sapiens

Alignment Length:	816	Identity:	195/816 - (23%)
Similarity:	319/816 - (39%)	Gaps:	196/816 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTLPRLETPLRRSAVGSYQEGVSRMLTPFNDDEAERREARR-------------RTLLQQHHRSS 52
            |.||| :.||........::      .|.||||.||.:.||             |.|.....||.
Human    36 MPLPR-KAPLNIPGTPVLED------FPQNDDEKERLQRRRSRVFDLQFSTDSPRLLASPSSRSI 93

  Fly    53 TLE-------SIEDNETIKNCLELYNGNKVSKDNAWNLMLIDSLANLLDHHHKRMSNFKMAGSSL 110
            .:.       :.:..|....|::|...||::..||:.|.|||.::.:|.......:|||:|..:|
Human    94 DISATIPKFTNTQITEHYSTCIKLSTENKITTKNAFGLHLIDFMSEILKQKDTEPTNFKVAAGTL 158

  Fly   111 EASSKVYGLRVDSIYLDAMRISAGLSARTLTDKQINAAEDDDGPQGEQATGEGQD--SAQQAAKE 173
            :||:|:|.:|||:::.|..|:..||.              .|.|..|:..|...|  :.:....:
Human   159 DASTKIYAVRVDAVHADVYRVLGGLG--------------KDAPSLEEVEGHVADGSATEMGTTK 209

  Fly   174 AAPKPKRQKKPISTVTKNRETLN-SRLDTAPLQDPVFGKLNSTVGSINASNRLMHNI-LPSFDSE 236
            .|.|||: |....|:.:|...|| |..|.....||:|.|..::....:.:...:..: ...:.||
Human   210 KAVKPKK-KHLHRTIEQNINNLNVSEADRKCEIDPMFQKTAASFDECSTAGVFLSTLHCQDYRSE 273

  Fly   237 LRLRTTYNFWNSEESTEEVQ----DHTTLNAEMEQWPATSLMSTNLMRKLLPHAERSNLRPLHTG 297
            |...:.....::.|..|..:    :.|.|.|.::|.                 ||...:.|...|
Human   274 LLFPSDVQTLSTGEPLELPELGCVEMTDLKAPLQQC-----------------AEDRQICPSLAG 321

  Fly   298 YIITSAPNPKSANEKAAEVVQDEDHDEGLDNADDMCVNEISMAFDINAE-----CEPMPDLDGPP 357
            :..|.              ...|.|:|.:....|. ..:....||||||     |...||    .
Human   322 FQFTQ--------------WDSETHNESVSALVDK-FKKNDQVFDINAEVDESDCGDFPD----G 367

  Fly   358 PLVLEVDSNELEELTA----------EEQMVINNCRRLRKQTEFIE----DLR---PVDGNSKLE 405
            .|..:.|:|:..:.||          :|...:.:|     |.|.|.    |:|   |:......|
Human   368 SLGDDFDANDEPDHTAVGDHEEFRSWKEPCQVQSC-----QEEMISLGDGDIRTMCPLLSMKPGE 427

  Fly   406 YSY---RPMDQISQFWAGPSHWKFKRTRPRSTFSQTNGQVDTQPIRTQRAKKSAHLNAN------ 461
            |||   |.|    ..||||.||:|:..|.:...||:..       :.:..||...::..
Human   428 YSYFSPRTM----SMWAGPDHWRFRPRRKQDAPSQSEN-------KKKSTKKDFEIDFEDDIDFD 481

  Fly   462 ---RRAKALDYGNVTENFFQQLDTTIRQRKANFQKKWDPRKLILPTKFELDPDLFFKYESAPSIK 523
               |:.||               .||..:.....:.|  |...|||.|..:.|...:....|..:
Human   482 VYFRKTKA---------------ATILTKSTLENQNW--RATTLPTDFNYNVDTLVQLHLKPGTR 529

  Fly   524 LSKRAGEPDSDEGGDLGIDMDADMHHDDDNDQELFNNEHFTDAVPANVSVIAAIAAEQAAEASMM 588
            |.|.|          .|..::.: |:::..|.: :||.:.|.      :....:.|..:.:..:.
Human   530 LLKMA----------QGHRVETE-HYEEIEDYD-YNNPNDTS------NFCPGLQAADSDDEDLD 576

  Fly   589 NVSAGEIGLTQMNA-TCN--NTVFEIG--TEFEG-------------APSQVAKVIVPFAKRAKV 635
            ::..|.:|.:.::. .|:  .|..:.|  .|.:|             .|.:|.|:.:.:||.||.
Human   577 DLFVGPVGNSDLSPYPCHPPKTAQQNGDTPEAQGLDITTYGESNLVAEPQKVNKIEIHYAKTAKK 641

  Fly   636 IDMKNLKKSCNSLIQKQLLNAVPEETIPSHPKKKGEHYSKGFASFQQVYQKL-PDL---LTTKMS 696
            :|||.||:|..||:  ..|:....:...:| ::.|:..:....:.:::...| .||   |...|:
Human   642 MDMKKLKQSMWSLL--TALSGKEADAEANH-REAGKEAALAEVADEKMLSGLTKDLQRSLPPVMA 703

  Fly   697 DSLSPSVAFYAVLHLANDLKLRLIPQEDLEDFQIRQ 732
            .:||..:||..:|||||:..|:|...|||.|..:||
Human   704 QNLSIPLAFACLLHLANEKNLKLEGTEDLSDVLVRQ 739

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
barr	NP_001286094.1	Cnd2	7..731	CDD:283450	189/807 (23%)
NCAPH	NP_056156.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67		13/37 (35%)
		Cnd2	55..738	CDD:283450	187/787 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	361..383		6/25 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	447..467		4/26 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160218
Domainoid	1	1.000	128	1.000	Domainoid score	I5323
eggNOG	1	0.900	-	-		E1_COG5229
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133986
Inparanoid	1	1.050	128	1.000	Inparanoid score	I4676
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG55639
OrthoDB	1	1.010	-	-		D159113at33208
OrthoFinder	1	1.000	-	-		FOG0004936
OrthoInspector	1	1.000	-	-		oto90624
orthoMCL	1	0.900	-	-		OOG6_103100
Panther	1	1.100	-	-	LDO	PTHR13108
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R216
SonicParanoid	1	1.000	-	-		X3476
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800