DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment COX4 and COX4I1

DIOPT Version :9

Sequence 1:	NP_001260612.1	Gene:	COX4 / 35279	FlyBaseID:	FBgn0032833	Length:	182	Species:	Drosophila melanogaster
Sequence 2:	XP_024305924.1	Gene:	COX4I1 / 1327	HGNCID:	2265	Length:	175	Species:	Homo sapiens

Alignment Length:	171	Identity:	58/171 - (33%)
Similarity:	84/171 - (49%)	Gaps:	23/171 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 AVHTLDKIGKREIVGYGWNGTAC-----------------YADRVDYPLPAV-RFREPTNEINAL 75
            |......:|||.|     :.:.|                 |.||.|:|||.| ..:..:....||
Human     9 ATRVFSLVGKRAI-----STSVCVRAHESVVKSEDFSLPAYMDRRDHPLPEVAHVKHLSASQKAL 68

  Fly    76 RAKEQGDWKKLSTQEIKALYRASFCQTIAEVQAGSGEWKLHLGVSLLFCAAAIWVAVLMNIFVYD 140
            :.||:..|..||..|...|||..|.::.||:..||.|||..:|.::.|......|.:....:||.
Human    69 KEKEKASWSSLSMDEKVELYRIKFKESFAEMNRGSNEWKTVVGGAMFFIGFTALVIMWQKHYVYG 133

  Fly   141 ELPVTFDEEHQKAQLQRIIDLEINPVTGLTSKWDYENKKWK 181
            .||.:||:|....|.:|::|:::||:.||.||||||..:||
Human   134 PLPQSFDKEWVAKQTKRMLDMKVNPIQGLASKWDYEKNEWK 174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
COX4	NP_001260612.1	COX4	50..181	CDD:281003	51/148 (34%)
COX4I1	XP_024305924.1	COX4	42..174	CDD:308537	50/131 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151498
Domainoid	1	1.000	111	1.000	Domainoid score	I6239
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	112	1.000	Inparanoid score	I4860
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48902
OrthoDB	1	1.010	-	-		D1591226at2759
OrthoFinder	1	1.000	-	-		FOG0002054
OrthoInspector	1	1.000	-	-		mtm8593
orthoMCL	1	0.900	-	-		OOG6_103849
Panther	1	1.100	-	-	O	PTHR10707
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4386
SonicParanoid	1	1.000	-	-		X922
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.900