|
Fly 465 HTVPTESNYVLFNPGPVP------SRHVQYKIRKPRPLSTHSDADSGFLSPCSPEEMRANPAILV 523
|..|..: ||.| |:....|...|..:...|....|...|.... |.
Human 26 HVPPARA-------GPQPCYLKLGSKVEVSKTTYPSQIPLKSQVLQGLQEPAGEG--------LP 75
Fly 524 LQQCDSVQ-GY-MEIYTDWANYYLERAKSKRKVTDLSADCRDGLLLAEVIEAVTSFKVPDLVKKP 586
|::..||: |: .:|||||||:||.::..||.:.||..|..||:|||::|:.|.:.|:.|:...|
Human 76 LRKSGSVENGFDTQIYTDWANHYLAKSGHKRLIRDLQQDVTDGVLLAQIIQVVANEKIEDINGCP 140
Fly 587 KNQQQMFDNVNSCLHVLRSQSVGGLENITTNDICAGRLKAVLALFFALSRFKQQAKQTKSIGVGC 651
||:.||.:|:::||:.|.::.: .::.::..:|..|.|||:|.|||:|||:|||.:|.:...:
Human 141 KNRSQMIENIDACLNFLAAKGI-NIQGLSAEEIRNGNLKAILGLFFSLSRYKQQQQQPQKQHL-- 202
Fly 652 GGGVGGSSSTLTGSGSVLGIGIGGLRTPGSSL----------------NQDKNQQEQQQQQQQQQ 700
...:..:.|.:.|:.|....| ||...: .|.|.|.|.|.....:.
Human 203 SSPLPPAVSQVAGAPSQCQAG-----TPQQQVPVTPQAPCQPHQPAPHQQSKAQAEMQSSASSKD 262
Fly 701 TPQQLAQSLENGNEMVNRQIAP--------AYAKVNGGTAIPLPATVMVQRRCPP----DKVRPL 753
:.|........|.:.::|...| :.||..|| :|....||... ||.:|:
Human 263 SSQSKIIRFTLGQKKISRLPGPTARVSAAGSEAKTRGG------STTANNRRSQSFNNYDKSKPV 321
Fly 754 ----PPTPNH--------TPSIPGL----------GKSGSDFNTSRPNSPPTSNHTIQSLKSGNN 796
||..:| ..|.||: |.|.:..|.|..::.|......:..:|.:.
Human 322 TSPPPPPSSHEKEPLASSASSHPGMSDNAPASLESGSSSTPTNCSTSSAIPQPGAATKPWRSKSL 386
Fly 797 N----------SLRPPSIKSGIPSPSSPQTAP-QKHSMLDKLKLFNKEKQQNAVNAASVASKTQI 850
: |::||..::..|:|.:.:.|| .:.|||:|||||| .:....|.........
Human 387 SVKHSATVSMLSVKPPGPEAPRPTPEAMKPAPNNQKSMLEKLKLFN---SKGGSKAGEGPGSRDT 448
Fly 851 QSKRTSSSSGFSSARSERSDSSLSLNDGHGSQLKPPSISV----------------SSQKPQPKT 899
..:|..:...|..:....:.|.:....|..| ..|.|:: ||.|...|.
Human 449 SCERLETLPSFEESEELEAASRMLTTVGPAS--SSPKIALKGIAQRTFSRALTNKKSSLKGNEKE 511
Fly 900 KQSKLLAAQQKKEQANKATKLDKKEKSPARSLNKEESGNESRSSTMGRTGKSSLVRAVGGVEKNT 964
|:. ||:::...|:..|.|: .|....|:.:|...|..| |......
Human 512 KEK-----QQREKDKEKSKDLAKR-ASVTERLDLKEEPKEDPS---------------GAAVPEM 555
Fly 965 PKTSSK-SSLHSKSDSKSSLKAPQLLQSPSSGGLPKP-IAAIKGTS---KLPSLGG---GAGHLP 1021
||.||| :|...|....:|.|...: :||..|:||| :.::.|.| ..||..| .:|.|.
Human 556 PKKSSKIASFIPKGGKLNSAKKEPM--APSHSGIPKPGMKSMPGKSPSAPAPSKEGERSRSGKLS 618
Fly 1022 AAESQQNQQLLKRETSDISSNISQPPPAEPPISTHAHIHQNQT--------------------PP 1066
:...||..||..|.:|. ||:::......|..:|..|...:|| |.
Human 619 SGLPQQKPQLDGRHSSS-SSSLASSEGKGPGGTTLNHSISSQTVSGSVGTTQTTGSNTVSVQLPQ 682
Fly 1067 P-------------PYYANSQP------TSHISSHGFLSEPS----TPQHS-SGIYG----SSRL 1103
| |:...||. |:..||.|...||| |.|.: ..:.| :.||
Human 683 PQQQYNHPNTATVAPFLYRSQTDTEGNVTAESSSTGVSVEPSHFTKTGQPALEELTGEDPEARRL 747
Fly 1104 PPPKSALSAPRKLEYN--------------------------AGPHILS---SPT---HHQRQGL 1136
...|:.....:.||.. :|..||| .|| ....|..
Human 748 RTVKNIADLRQNLEETMSSLRGTQVTHSTLETTFDTNVTTEMSGRSILSLTGRPTPLSWRLGQSS 812
Fly 1137 PRPLVNSAPNTPTASPNKFHTIPSKIVGT-----IYESKEEQLLPAPPPASGGSSILPMRPLLRG 1196
||.....||:.....|.:.:. |:.:.| :|.:...:.| ||.|||:
Human 813 PRLQAGDAPSMGNGYPPRANA--SRFINTESGRYVYSAPLRRQL-----ASRGSSV--------- 861
Fly 1197 YNSHVTLPTRGARGGHHPHQSYLDFCESDI------GQGYCSDGDALRVGSSPGGSRFHDIDNGY 1255
.||.:..:... |.|: ..||.||||.| ....|..||.:||
Human 862 --CHVDVSDKAGD-------------EMDLEGISMDAPGYMSDGDVL-----SKNIRTDDITSGY 906
Fly 1256 LSEGSSGLNGPSSSAGGISPGKHFLSMMRARTQLPTT------------------IEERIRNSRG 1302
:::|..||. :.....:..| ::::|...|..|: |.:.|.|.
Human 907 MTDGGLGLY--TRRLNRLPDG---MAVVRETLQRNTSLGLGDADSWDDSSSVSSGISDTIDNL-- 964
Fly 1303 SLDSIGTAANGSSAASQASSSGGS------TTTHAQNNNNN---------NNNNSGGGAKMDGSP 1352
|.|.|.|:::.||.|:..:||..: ...|:|...|: ::..|..|.||:
Human 965 STDDINTSSSISSYANTPASSRKNLDVQTDAEKHSQVERNSLWSGDDVKKSDGGSDSGIKME--- 1026
Fly 1353 HHRPGSR----------------NGRDN--------WSK---------MPE------------PL 1372
|||: :|:.| |.: ||. |.
Human 1027 ---PGSKWRRNPSDVSDESDKSTSGKKNPVISQTGSWRRGMTAQVGITMPRTKPSAPAGALKTPG 1088
Fly 1373 NG--------QKVEKSDKSSPSRRSMGGGG--SGSSSKQGSPSSSSRTKGVPPSFGYVKRANGSI 1427
.| :|...|.|:|..:||....| ||..||:..||||........|||: |:.:||.
Human 1089 TGKTDDAKVSEKGRLSPKASQVKRSPSDAGRSSGDESKKPLPSSSRTPTANANSFGF-KKQSGSA 1152
Fly 1428 ASTAEQQNIAMMMAAG-GAGANGLPCGRTAHVSAVPRTASGRKVA-GGTQTLPNDMNKLP--PNT 1488
| .:||:.|:| ...:.....|:....||:...::|||.: .|.|...:....|. .|.
Human 1153 A------GLAMITASGVTVTSRSATLGKIPKSSALVSRSAGRKSSMDGAQNQDDGYLALSSRTNL 1211
Fly 1489 QHRSF-------SLTGPTATQLSQSIRERLATGSHSLPKP----------GSDLHVFQHRISNRG 1536
|:||. |..|......:.||...:::.|..||.| ||.|....::..
Human 1212 QYRSLPRPSKSNSRNGAGNRSSTSSIDSNISSKSAGLPVPKLREPSKTALGSSLPGLVNQTD--- 1273
Fly 1537 GTRHDGSLSDTQTYA---EVK----------PEYSSYAMWLKHSNTAG---SRLSDGESVEQLQI 1585
:..|..||.::.| .|| |..:|.....|:.:.|. .||..|:..:|:.|
Human 1274 --KEKGISSDNESVASCNSVKVNPAAQPVSSPAQTSLQPGAKYPDVASPTLRRLFGGKPTKQVPI 1336
Fly 1586 GS--------------PALTRHGHKMIHNRSGGPGQMAGQMSG--------NESPYVQSPR---- 1624
.: ..:|:.|: :.:.||.....:|..|. |:||...||.
Human 1337 ATAENMKNSVVISNPHATMTQQGN--LDSPSGSGVLSSGSSSPLYSKNVDLNQSPLASSPSSAHS 1399
Fly 1625 ---------MNRSNS-----------------------------------------IRSTKSEKM 1639
.|.|:| |.|:|.:.:
Human 1400 APSNSLTWGTNASSSSAVSKDGLGFQSVSSLHTSCESIDISLSSGGVPSHNSSTGLIASSKDDSL 1464
Fly 1640 YPSMMSRAGEVEI----------EPYYC------------------LP-VGTNGVLTAQMAAAMA 1675
.|.:.:.:.:..: .|.:| || .|.....|:|:.....
Human 1465 TPFVRTNSVKTTLSESPLSSPAASPKFCRSTLPRKQDSDPHLDRNTLPKKGLRYTPTSQLRTQED 1529
Fly 1676 A----QSQAAQGNPGVGVNVGGVAWSQPTSPTPLTRGPFN------TAAGASVLSP----THGTT 1726
| :|.:|.|......|....:.|..|||:. ||..|: |....|:.:| ||..:
Human 1530 AKEWLRSHSAGGLQDTAANSPFSSGSSVTSPSG-TRFNFSQLASPTTVTQMSLSNPTMLRTHSLS 1593
Fly 1727 SAAGLVGP-----------------------GGGAGG------------------------GAMV 1744
:|.|...| |....| ...:
Human 1594 NADGQYDPYTDSRFRNSSMSLDEKSRTMSRSGSFRDGFEEESWEKSSVDNFVSRLHSSLHFSLPL 1658
Fly 1745 GHRLTYPKKNDEVHGSAASLLSGGSSLYGNAEERQAHEIRRLKRELQDARDQVLSLSSQLSTNAH 1809
.|...| :.||||:.||:|..||:|...||:...|||:|:|||..::::|.:|::||:.|||
Human 1659 FHHARY----ELVHGSSLSLVSSTSSVYSTPEEKCQSEIRKLRRELDASQEKVSALTTQLTANAH 1719
Fly 1810 VVTAFEQSLSNMTNRLHQLTATAERKDGELTDMRQTIELLRKQSIQAGLTTAHMQSMGVQTQGQG 1874
:|.||||||.|||.||..||.|||:||.||.::|:|||||:||
Human 1720 LVAAFEQSLGNMTIRLQSLTMTAEQKDSELNELRKTIELLKKQ---------------------- 1762
Fly 1875 QVQGQALGQALGQPGSDQKPPNSGSQRAINA----------NNG---SMPLGMQRQHSTDSMCSL 1926
|:.:|.|||. .|| |..|.::||||:||:.|:
Human 1763 ---------------------NAAAQAAINGVINTPELNCKGNGTAQSADLRIRRQHSSDSVSSI 1806
Fly 1927 NSISSGCSAA---QDKNKANKKKGW---LRSSFTKAFSRNAKISKTSRHVGHHHHHNHSQQELAS 1985
||.:|..|.. :..:|..|:|.| |||||.:||.:.......|.|.......:.|.. :|
Human 1807 NSATSHSSVGSNIESDSKKKKRKNWVNELRSSFKQAFGKKKSPKSASSHSDIEEMTDSSLP--SS 1869
Fly 1986 GKLPLHNGHGEPLGLASLATQPAPPLPNSKQSSPAKTVTLIDNAKPIDAIDQEDQHVVEDLKKQL 2050
.||| ||| :|...|.|.||..:| ||. :.:|.|.:.|:: |:.:|
Human 1870 PKLP-HNG----------STGSTPLLRNSHSNS------LIS-----ECMDSEAETVMQ-LRNEL 1911
Fly 2051 REKDLVLTDIRLEALSSASQLESLKEMMNKMRAEMMSLKHNNERLQKLVTTRSLAGSEASLGQAI 2115
|:|::.||||||||||||.||:.|:|.||:|::|:..||..|:||: ||:
Human 1912 RDKEMKLTDIRLEALSSAHQLDQLREAMNRMQSEIEKLKAENDRLK----------SES------ 1960
Fly 2116 SPNGSVAGSSEVSRRYSLADSNSRPPMELPARLSEELELEEDCLPPAPAPEQPPPPAPNGVSVAP 2180
.|| |.|....:.|::.| |.:........|.|.|
Human 1961 --QGS--GCSRAPSQVSISAS----PRQSMGLSQHSLNLTE------------------------ 1993
Fly 2181 LSPSTHVDLTPPPPALEAAPMASPVHMASATEELADVCDGKKIAIACYLGQPEAFAKYCEELQEL 2245
||.:|: :.......||.:| .|:.:.|. ..:.||::
Human 1994 ---STSLDM-----------LLDDTGECSARKE-----GGRHVKIV---------VSFQEEMK-- 2028
Fly 2246 DGFYANGHEADSQSQSERKSNYTSASCNEFVIACTYISGKTTWQNLDYVVRKTFKDYVARIDPGT 2310
.:.||:. :.|:|.|..:||||.|..||.|||:.||:|:..:||.:
Human 2029 -------WKEDSRP-------------HLFLIGCIGVSGKTKWDVLDGVVRRLFKEYIIHVDPVS 2073
Fly 2311 NLGLNTDSITSYHLGEAKRGPEMGFPELLPCGYIVGSVRTLYICLQGVG-----SLAFDSLIPRS 2370
.||||:||:..|.:||.||......||||||||:||...|:.:.::|:. ||.|:||||:.
Human 2074 QLGLNSDSVLGYSIGEIKRSNTSETPELLPCGYLVGENTTISVTVKGLAENSLDSLVFESLIPKP 2138
Fly 2371 IVHRYISLLTEHRRLILCGPSGTGKSYLARRLAEFLVARSARGNPSEAIATFNVDHKSSKDLRQY 2435
|:.||:|||.||||:||.|||||||:|||.||:|::|.|..|......||||||||||||:||||
Human 2139 ILQRYVSLLIEHRRIILSGPSGTGKTYLANRLSEYIVLREGRELTDGVIATFNVDHKSSKELRQY 2203
Fly 2436 LGHIAEQAAIANGVSELPSVIILDNLHHASALGDVFSCLLSAGPANKLPCIIGTMSQATCNTTNL 2500
|.::|:|....|...::|.|||||||||.|:||::|:.||:. ..:|.|.|||||:|||.:|.||
Human 2204 LSNLADQCNSENNAVDMPLVIILDNLHHVSSLGEIFNGLLNC-KYHKCPYIIGTMNQATSSTPNL 2267
Fly 2501 QLHHNFRWVLTANHMEPVKGFLGRFLRRRLFQLELQTQHPQPELAAVLAWLPSVWQHINRFLEVH 2565
||||||||||.|||.|||||||||||||:|.:.|:..:....||..::.|:|.||.|:|||||.|
Human 2268 QLHHNFRWVLCANHTEPVKGFLGRFLRRKLMETEISGRVRNMELVKIIDWIPKVWHHLNRFLEAH 2332
Fly 2566 SSSDVTIGPRLFLACPMDLKDSQVWFTDIWNYHLSPYLVEAVREGVQLYGRRGGAWNDPSAFIRN 2630
|||||||||||||:||:|:..|:|||||:|||.:.|||:||||||:|||||| ..|.||:.::.:
Human 2333 SSSDVTIGPRLFLSCPIDVDGSRVWFTDLWNYSIIPYLLEAVREGLQLYGRR-APWEDPAKWVMD 2396
Fly 2631 SYPWPYGPD--SVPPLRQINAEDVGLEGVAL-----------TNGDQQDPLLNMLMRLQEAANYS 2682
:|||...|. ..|||.|:..||||.:|.:: .:..:.|||:|||||||||||||
Human 2397 TYPWAASPQQHEWPPLLQLRPEDVGFDGYSMPREGSTSKQMPPSDAEGDPLMNMLMRLQEAANYS 2461
Fly 2683 EAQDQESDCAS-------LDSNV 2698
..|..:||..| |||::
Human 2462 SPQSYDSDSNSNSHHDDILDSSL 2484
| 
