DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sick and NAV2

DIOPT Version :9

Sequence 1:NP_001260606.1 Gene:sick / 35277 FlyBaseID:FBgn0263873 Length:2707 Species:Drosophila melanogaster
Sequence 2:NP_001231892.1 Gene:NAV2 / 89797 HGNCID:15997 Length:2488 Species:Homo sapiens


Alignment Length:2747 Identity:788/2747 - (28%)
Similarity:1145/2747 - (41%) Gaps:801/2747 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly   465 HTVPTESNYVLFNPGPVP------SRHVQYKIRKPRPLSTHSDADSGFLSPCSPEEMRANPAILV 523
            |..|..:       ||.|      |:....|...|..:...|....|...|....        |.
Human    26 HVPPARA-------GPQPCYLKLGSKVEVSKTTYPSQIPLKSQVLQGLQEPAGEG--------LP 75

  Fly   524 LQQCDSVQ-GY-MEIYTDWANYYLERAKSKRKVTDLSADCRDGLLLAEVIEAVTSFKVPDLVKKP 586
            |::..||: |: .:|||||||:||.::..||.:.||..|..||:|||::|:.|.:.|:.|:...|
Human    76 LRKSGSVENGFDTQIYTDWANHYLAKSGHKRLIRDLQQDVTDGVLLAQIIQVVANEKIEDINGCP 140

  Fly   587 KNQQQMFDNVNSCLHVLRSQSVGGLENITTNDICAGRLKAVLALFFALSRFKQQAKQTKSIGVGC 651
            ||:.||.:|:::||:.|.::.: .::.::..:|..|.|||:|.|||:|||:|||.:|.:...:  
Human   141 KNRSQMIENIDACLNFLAAKGI-NIQGLSAEEIRNGNLKAILGLFFSLSRYKQQQQQPQKQHL-- 202

  Fly   652 GGGVGGSSSTLTGSGSVLGIGIGGLRTPGSSL----------------NQDKNQQEQQQQQQQQQ 700
            ...:..:.|.:.|:.|....|     ||...:                .|.|.|.|.|.....:.
Human   203 SSPLPPAVSQVAGAPSQCQAG-----TPQQQVPVTPQAPCQPHQPAPHQQSKAQAEMQSSASSKD 262

  Fly   701 TPQQLAQSLENGNEMVNRQIAP--------AYAKVNGGTAIPLPATVMVQRRCPP----DKVRPL 753
            :.|........|.:.::|...|        :.||..||      :|....||...    ||.:|:
Human   263 SSQSKIIRFTLGQKKISRLPGPTARVSAAGSEAKTRGG------STTANNRRSQSFNNYDKSKPV 321

  Fly   754 ----PPTPNH--------TPSIPGL----------GKSGSDFNTSRPNSPPTSNHTIQSLKSGNN 796
                ||..:|        ..|.||:          |.|.:..|.|..::.|......:..:|.:.
Human   322 TSPPPPPSSHEKEPLASSASSHPGMSDNAPASLESGSSSTPTNCSTSSAIPQPGAATKPWRSKSL 386

  Fly   797 N----------SLRPPSIKSGIPSPSSPQTAP-QKHSMLDKLKLFNKEKQQNAVNAASVASKTQI 850
            :          |::||..::..|:|.:.:.|| .:.|||:||||||   .:....|.........
Human   387 SVKHSATVSMLSVKPPGPEAPRPTPEAMKPAPNNQKSMLEKLKLFN---SKGGSKAGEGPGSRDT 448

  Fly   851 QSKRTSSSSGFSSARSERSDSSLSLNDGHGSQLKPPSISV----------------SSQKPQPKT 899
            ..:|..:...|..:....:.|.:....|..|  ..|.|::                ||.|...|.
Human   449 SCERLETLPSFEESEELEAASRMLTTVGPAS--SSPKIALKGIAQRTFSRALTNKKSSLKGNEKE 511

  Fly   900 KQSKLLAAQQKKEQANKATKLDKKEKSPARSLNKEESGNESRSSTMGRTGKSSLVRAVGGVEKNT 964
            |:.     ||:::...|:..|.|: .|....|:.:|...|..|               |......
Human   512 KEK-----QQREKDKEKSKDLAKR-ASVTERLDLKEEPKEDPS---------------GAAVPEM 555

  Fly   965 PKTSSK-SSLHSKSDSKSSLKAPQLLQSPSSGGLPKP-IAAIKGTS---KLPSLGG---GAGHLP 1021
            ||.||| :|...|....:|.|...:  :||..|:||| :.::.|.|   ..||..|   .:|.|.
Human   556 PKKSSKIASFIPKGGKLNSAKKEPM--APSHSGIPKPGMKSMPGKSPSAPAPSKEGERSRSGKLS 618

  Fly  1022 AAESQQNQQLLKRETSDISSNISQPPPAEPPISTHAHIHQNQT--------------------PP 1066
            :...||..||..|.:|. ||:::......|..:|..|...:||                    |.
Human   619 SGLPQQKPQLDGRHSSS-SSSLASSEGKGPGGTTLNHSISSQTVSGSVGTTQTTGSNTVSVQLPQ 682

  Fly  1067 P-------------PYYANSQP------TSHISSHGFLSEPS----TPQHS-SGIYG----SSRL 1103
            |             |:...||.      |:..||.|...|||    |.|.: ..:.|    :.||
Human   683 PQQQYNHPNTATVAPFLYRSQTDTEGNVTAESSSTGVSVEPSHFTKTGQPALEELTGEDPEARRL 747

  Fly  1104 PPPKSALSAPRKLEYN--------------------------AGPHILS---SPT---HHQRQGL 1136
            ...|:.....:.||..                          :|..|||   .||   ....|..
Human   748 RTVKNIADLRQNLEETMSSLRGTQVTHSTLETTFDTNVTTEMSGRSILSLTGRPTPLSWRLGQSS 812

  Fly  1137 PRPLVNSAPNTPTASPNKFHTIPSKIVGT-----IYESKEEQLLPAPPPASGGSSILPMRPLLRG 1196
            ||.....||:.....|.:.:.  |:.:.|     :|.:...:.|     ||.|||:         
Human   813 PRLQAGDAPSMGNGYPPRANA--SRFINTESGRYVYSAPLRRQL-----ASRGSSV--------- 861

  Fly  1197 YNSHVTLPTRGARGGHHPHQSYLDFCESDIGQGYCSDGDALRVGSSPGGSRFHDIDNGYLSEGSS 1261
              .||.:..:..      .:..|:....| ..||.||||.|     ....|..||.:||:::|..
Human   862 --CHVDVSDKAG------DEMDLEGISMD-APGYMSDGDVL-----SKNIRTDDITSGYMTDGGL 912

  Fly  1262 GLNGPSSSAGGISPGKHFLSMMRARTQLPTT------------------IEERIRNSRGSLDSIG 1308
            ||.  :.....:..|   ::::|...|..|:                  |.:.|.|.  |.|.|.
Human   913 GLY--TRRLNRLPDG---MAVVRETLQRNTSLGLGDADSWDDSSSVSSGISDTIDNL--STDDIN 970

  Fly  1309 TAANGSSAASQASSSGGS------TTTHAQNNNNN---------NNNNSGGGAKMDGSPHHRPGS 1358
            |:::.||.|:..:||..:      ...|:|...|:         ::..|..|.||:      |||
Human   971 TSSSISSYANTPASSRKNLDVQTDAEKHSQVERNSLWSGDDVKKSDGGSDSGIKME------PGS 1029

  Fly  1359 R----------------NGRDN--------WSK---------MPE------------PLNG---- 1374
            :                :|:.|        |.:         ||.            |..|    
Human  1030 KWRRNPSDVSDESDKSTSGKKNPVISQTGSWRRGMTAQVGITMPRTKPSAPAGALKTPGTGKTDD 1094

  Fly  1375 ----QKVEKSDKSSPSRRSMGGGG--SGSSSKQGSPSSSSRTKGVPPSFGYVKRANGSIASTAEQ 1433
                :|...|.|:|..:||....|  ||..||:..||||........|||: |:.:||.|     
Human  1095 AKVSEKGRLSPKASQVKRSPSDAGRSSGDESKKPLPSSSRTPTANANSFGF-KKQSGSAA----- 1153

  Fly  1434 QNIAMMMAAG-GAGANGLPCGRTAHVSAVPRTASGRKVA-GGTQTLPNDMNKLP--PNTQHRSF- 1493
             .:||:.|:| ...:.....|:....||:...::|||.: .|.|...:....|.  .|.|:||. 
Human  1154 -GLAMITASGVTVTSRSATLGKIPKSSALVSRSAGRKSSMDGAQNQDDGYLALSSRTNLQYRSLP 1217

  Fly  1494 ------SLTGPTATQLSQSIRERLATGSHSLPKP----------GSDLHVFQHRISNRGGTRHDG 1542
                  |..|......:.||...:::.|..||.|          ||.|....::..     :..|
Human  1218 RPSKSNSRNGAGNRSSTSSIDSNISSKSAGLPVPKLREPSKTALGSSLPGLVNQTD-----KEKG 1277

  Fly  1543 SLSDTQTYA---EVK----------PEYSSYAMWLKHSNTAG---SRLSDGESVEQLQIGS---- 1587
            ..||.::.|   .||          |..:|.....|:.:.|.   .||..|:..:|:.|.:    
Human  1278 ISSDNESVASCNSVKVNPAAQPVSSPAQTSLQPGAKYPDVASPTLRRLFGGKPTKQVPIATAENM 1342

  Fly  1588 ----------PALTRHGHKMIHNRSGGPGQMAGQMSG--------NESPYVQSPR---------- 1624
                      ..:|:.|:  :.:.||.....:|..|.        |:||...||.          
Human  1343 KNSVVISNPHATMTQQGN--LDSPSGSGVLSSGSSSPLYSKNVDLNQSPLASSPSSAHSAPSNSL 1405

  Fly  1625 ---MNRSNS-----------------------------------------IRSTKSEKMYPSMMS 1645
               .|.|:|                                         |.|:|.:.:.|.:.:
Human  1406 TWGTNASSSSAVSKDGLGFQSVSSLHTSCESIDISLSSGGVPSHNSSTGLIASSKDDSLTPFVRT 1470

  Fly  1646 RAGEVEI----------EPYYC------------------LP-VGTNGVLTAQMAAAMAA----Q 1677
            .:.:..:          .|.:|                  || .|.....|:|:.....|    :
Human  1471 NSVKTTLSESPLSSPAASPKFCRSTLPRKQDSDPHLDRNTLPKKGLRYTPTSQLRTQEDAKEWLR 1535

  Fly  1678 SQAAQGNPGVGVNVGGVAWSQPTSPTPLTRGPFN------TAAGASVLSP----THGTTSAAGLV 1732
            |.:|.|......|....:.|..|||:. ||..|:      |....|:.:|    ||..::|.|..
Human  1536 SHSAGGLQDTAANSPFSSGSSVTSPSG-TRFNFSQLASPTTVTQMSLSNPTMLRTHSLSNADGQY 1599

  Fly  1733 GP-----------------------GGGAGG------------------------GAMVGHRLTY 1750
            .|                       |....|                        ...:.|...|
Human  1600 DPYTDSRFRNSSMSLDEKSRTMSRSGSFRDGFEEESWEKSSVDNFVSRLHSSLHFSLPLFHHARY 1664

  Fly  1751 PKKNDEVHGSAASLLSGGSSLYGNAEERQAHEIRRLKRELQDARDQVLSLSSQLSTNAHVVTAFE 1815
                :.||||:.||:|..||:|...||:...|||:|:|||..::::|.:|::||:.|||:|.|||
Human  1665 ----ELVHGSSLSLVSSTSSVYSTPEEKCQSEIRKLRRELDASQEKVSALTTQLTANAHLVAAFE 1725

  Fly  1816 QSLSNMTNRLHQLTATAERKDGELTDMRQTIELLRKQSIQAGLTTAHMQSMGVQTQGQGQVQGQA 1880
            |||.|||.||..||.|||:||.||.::|:|||||:||                            
Human  1726 QSLGNMTIRLQSLTMTAEQKDSELNELRKTIELLKKQ---------------------------- 1762

  Fly  1881 LGQALGQPGSDQKPPNSGSQRAINA----------NNG---SMPLGMQRQHSTDSMCSLNSISSG 1932
                           |:.:|.|||.          .||   |..|.::||||:||:.|:||.:|.
Human  1763 ---------------NAAAQAAINGVINTPELNCKGNGTAQSADLRIRRQHSSDSVSSINSATSH 1812

  Fly  1933 CSAA---QDKNKANKKKGW---LRSSFTKAFSRNAKISKTSRHVGHHHHHNHSQQELASGKLPLH 1991
            .|..   :..:|..|:|.|   |||||.:||.:.......|.|.......:.|..  :|.||| |
Human  1813 SSVGSNIESDSKKKKRKNWVNELRSSFKQAFGKKKSPKSASSHSDIEEMTDSSLP--SSPKLP-H 1874

  Fly  1992 NGHGEPLGLASLATQPAPPLPNSKQSSPAKTVTLIDNAKPIDAIDQEDQHVVEDLKKQLREKDLV 2056
            ||          :|...|.|.||..:|      ||.     :.:|.|.:.|:: |:.:||:|::.
Human  1875 NG----------STGSTPLLRNSHSNS------LIS-----ECMDSEAETVMQ-LRNELRDKEMK 1917

  Fly  2057 LTDIRLEALSSASQLESLKEMMNKMRAEMMSLKHNNERLQKLVTTRSLAGSEASLGQAISPNGSV 2121
            ||||||||||||.||:.|:|.||:|::|:..||..|:||:          ||:        .|| 
Human  1918 LTDIRLEALSSAHQLDQLREAMNRMQSEIEKLKAENDRLK----------SES--------QGS- 1963

  Fly  2122 AGSSEVSRRYSLADSNSRPPMELPARLSEELELEEDCLPPAPAPEQPPPPAPNGVSVAPLSPSTH 2186
             |.|....:.|::.|    |.:........|.|.|                           ||.
Human  1964 -GCSRAPSQVSISAS----PRQSMGLSQHSLNLTE---------------------------STS 1996

  Fly  2187 VDLTPPPPALEAAPMASPVHMASATEELADVCDGKKIAIACYLGQPEAFAKYCEELQELDGFYAN 2251
            :|:           :.......||.:|     .|:.:.|.         ..:.||::        
Human  1997 LDM-----------LLDDTGECSARKE-----GGRHVKIV---------VSFQEEMK-------- 2028

  Fly  2252 GHEADSQSQSERKSNYTSASCNEFVIACTYISGKTTWQNLDYVVRKTFKDYVARIDPGTNLGLNT 2316
             .:.||:.             :.|:|.|..:||||.|..||.|||:.||:|:..:||.:.||||:
Human  2029 -WKEDSRP-------------HLFLIGCIGVSGKTKWDVLDGVVRRLFKEYIIHVDPVSQLGLNS 2079

  Fly  2317 DSITSYHLGEAKRGPEMGFPELLPCGYIVGSVRTLYICLQGVG-----SLAFDSLIPRSIVHRYI 2376
            ||:..|.:||.||......||||||||:||...|:.:.::|:.     ||.|:||||:.|:.||:
Human  2080 DSVLGYSIGEIKRSNTSETPELLPCGYLVGENTTISVTVKGLAENSLDSLVFESLIPKPILQRYV 2144

  Fly  2377 SLLTEHRRLILCGPSGTGKSYLARRLAEFLVARSARGNPSEAIATFNVDHKSSKDLRQYLGHIAE 2441
            |||.||||:||.|||||||:|||.||:|::|.|..|......||||||||||||:|||||.::|:
Human  2145 SLLIEHRRIILSGPSGTGKTYLANRLSEYIVLREGRELTDGVIATFNVDHKSSKELRQYLSNLAD 2209

  Fly  2442 QAAIANGVSELPSVIILDNLHHASALGDVFSCLLSAGPANKLPCIIGTMSQATCNTTNLQLHHNF 2506
            |....|...::|.|||||||||.|:||::|:.||:. ..:|.|.|||||:|||.:|.||||||||
Human  2210 QCNSENNAVDMPLVIILDNLHHVSSLGEIFNGLLNC-KYHKCPYIIGTMNQATSSTPNLQLHHNF 2273

  Fly  2507 RWVLTANHMEPVKGFLGRFLRRRLFQLELQTQHPQPELAAVLAWLPSVWQHINRFLEVHSSSDVT 2571
            ||||.|||.|||||||||||||:|.:.|:..:....||..::.|:|.||.|:|||||.|||||||
Human  2274 RWVLCANHTEPVKGFLGRFLRRKLMETEISGRVRNMELVKIIDWIPKVWHHLNRFLEAHSSSDVT 2338

  Fly  2572 IGPRLFLACPMDLKDSQVWFTDIWNYHLSPYLVEAVREGVQLYGRRGGAWNDPSAFIRNSYPWPY 2636
            |||||||:||:|:..|:|||||:|||.:.|||:||||||:|||||| ..|.||:.::.::|||..
Human  2339 IGPRLFLSCPIDVDGSRVWFTDLWNYSIIPYLLEAVREGLQLYGRR-APWEDPAKWVMDTYPWAA 2402

  Fly  2637 GPD--SVPPLRQINAEDVGLEGVAL-----------TNGDQQDPLLNMLMRLQEAANYSEAQDQE 2688
            .|.  ..|||.|:..||||.:|.::           .:..:.|||:|||||||||||||..|..:
Human  2403 SPQQHEWPPLLQLRPEDVGFDGYSMPREGSTSKQMPPSDAEGDPLMNMLMRLQEAANYSSPQSYD 2467

  Fly  2689 SDCAS-------LDSNV 2698
            ||..|       |||::
Human  2468 SDSNSNSHHDDILDSSL 2484

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sickNP_001260606.1 CH 535..637 CDD:214479 43/101 (43%)
AAA 2382..2531 CDD:214640 96/148 (65%)
AAA_22 2385..2476 CDD:290137 53/90 (59%)
NAV2NP_001231892.1 CH 89..190 CDD:237981 43/101 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..675 113/522 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 706..727 7/20 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 804..824 5/19 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 939..1151 48/220 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1177..1200 7/22 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1213..1283 16/74 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1295..1338 9/42 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1355..1412 12/58 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1440..1460 2/19 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1473..1560 14/86 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1591..1629 4/37 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1790..1887 36/109 (33%)
PRKG1_interact 1907..1959 CDD:292521 29/61 (48%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1951..1985 12/57 (21%)
AAA 2150..2258 CDD:214640 63/108 (58%)
AAA_22 2153..>2240 CDD:290137 51/86 (59%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2423..2488 24/62 (39%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 401 1.000 Domainoid score I735
eggNOG 1 0.900 - - E1_2CMAI
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 861 1.000 Inparanoid score I432
Isobase 1 0.950 - 1 Normalized mean entropy S5133
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001074
OrthoInspector 1 1.000 - - oto89649
orthoMCL 1 0.900 - - OOG6_103597
Panther 1 1.100 - - O PTHR12784
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3248
SonicParanoid 1 1.000 - - X908
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.930

Return to query results.
Submit another query.