DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sick and NAV1

DIOPT Version :9

Sequence 1:	NP_001260606.1	Gene:	sick / 35277	FlyBaseID:	FBgn0263873	Length:	2707	Species:	Drosophila melanogaster
Sequence 2:	NP_001376546.1	Gene:	NAV1 / 89796	HGNCID:	15989	Length:	2164	Species:	Homo sapiens

Alignment Length:	2415	Identity:	633/2415 - (26%)
Similarity:	949/2415 - (39%)	Gaps:	683/2415 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   711 NGNEMVNRQIAPAYAKVNGGTAIPLPATVMVQRRCP----PDKVRP----LPPTPNHTPSIPGLG 767
            ||...||....|.||     :|||:| ....|.|.|    ..::||    |..:|....| |.||
Human     2 NGMANVNPASRPHYA-----SAIPVP-RASSQTRIPTPGASPQLRPRQAGLALSPQRAAS-PRLG 59

  Fly   768 KSGSDFNTSRP------------------------------NSPPTSNHTIQSLKSGN------- 795
            |:......|.|                              |||.|:.....|.::|:
Human    60 KAAGPSRNSSPRAFRGRGSPKFAGAVRESAEDGEGPFSSPWNSPRTTPKAALSSRAGSGRIGERQ 124

  Fly   796 ----------------NNSLRPPSIKS--------GIPSPSSPQTAPQKHSMLDKLKLFNK---- 832
                            ....|.||..|        |.|....|.:.|.|    |:..:..|
Human   125 GTQGKKKKAQEGTPVCQTRGRSPSRTSFHGETQIPGAPEGRKPPSCPGK----DQRDINYKSSGT 185

  Fly   833 ----EKQQNAVNAASVASKTQIQSKRTSSSSGFSSARSERSDSSLSLNDGHGSQLKPPSISV--- 890
                |..:.|.:.||....:.:|.||.|.|.|           ::|.:..| .|.:|.:.:|
Human   186 PRSLEPDEGAASWASSPVCSPVQGKRPSPSPG-----------AISFSSVH-QQSQPVTATVAPF 238

  Fly   891 -----SSQKPQP----------------KTKQS----------KLLA------------------ 906
                 :.|||.|                :|::|          .|||
Human   239 QYRLQTDQKPGPLSQGSWPLDGYAEPLHETEESFSCMDARIVHALLAGRMLGSSVKSVQPEVELS 303

  Fly   907 -------AQQKKEQANKATKLDKKEKSPARSLNKEESGNESRSSTMG-RTGKSSLV--RAVGG-V 960
                   |.:.:....||...|.:...|.|:......|..:::|... :..||..|  |..|| .
Human   304 SGGGDEGADEPRGAGRKAAAADGRGMLPKRAKAPGGGGGMAKASAAELKVFKSGSVDSRVPGGPP 368

  Fly   961 EKNTPKTSSKSSLHSKSDSKSSLKAPQLLQSPSSGGLPKPIAAIKGTSKLPSLGGGAGHLPAAES 1025
            ..|..|..|.::|...:||:..|   ||.:...|..:.|   |.||..|:.|.|..|..:....|
Human   369 ASNLRKQKSLTNLSFLTDSEKKL---QLYEPEWSDDMAK---APKGLGKVGSKGREAPLMSKTLS 427

  Fly  1026 QQNQQLLKRETSDISSNISQPPPAEPPISTHAHIHQNQTPPPPYY----ANSQPTSHISSHG--- 1083
            :....|.:.:.|......:...|..|.:...:.|     |..||.    .:..|.:.:|..|
Human   428 KSEHSLFQAKGSPAGGAKTPLAPLAPNLGKPSRI-----PRGPYAEVKPLSKAPEAAVSEDGKSD 487

  Fly  1084 --FLSEPSTPQHSSG-----------------------IYGS------SRLPPPKS--------A 1109
              .||..:..|.|||                       :.|.      |::..|:|        .
Human   488 DELLSSKAKAQKSSGPVPSAKGQEERAFLKVDPELVVTVLGDLEQLLFSQMLDPESQRKRTVQNV 552

  Fly  1110 LSAPRKLEYNAGPHILSSPTHHQRQGLPRPLVNSAPNTPTASPNKFHTIP--SKIVGTIYESKEE 1172
            |...:.||........|..||..       |..:..::..|:|....::.  |..:...|.....
Human   553 LDLRQNLEETMSSLRGSQVTHSS-------LEMTCYDSDDANPRSVSSLSNRSSPLSWRYGQSSP 610

  Fly  1173 QLLPAPPPASGGSSILPMRPLL-----RGYNSHVTLPTRGARGGHHPHQSYLDFCES------DI 1226
            :|.....|:.|||......|..     |.:.|| |:|.|..  ....|.|.|:..||      |:
Human   611 RLQAGDAPSVGGSCRSEGTPAWYMHGERAHYSH-TMPMRSP--SKLSHISRLELVESLDSDEVDL 672

  Fly  1227 GQGYCSDGDALRVGSSPGGSRFHDIDNGYLSEGSSGLNGPSSSAGGISPGKHFLSMMRARTQLPT 1291
            ..||.||.|.:  |.:.  :...||..|: .|.||..:|.|.::..:|..:  .:...:...||:
Human   673 KSGYMSDSDLM--GKTM--TEDDDITTGW-DESSSISSGLSDASDNLSSEE--FNASSSLNSLPS 730

  Fly  1292 TIEERIRNS----RGSLDSIGTAANGSSAASQAS---------SSG------GSTTTHAQNNNNN 1337
            |.....|||    |...:....|.:|.|..|::.         .||      |::....:...:.
Human   731 TPTASRRNSTIVLRTDSEKRSLAESGLSWFSESEEKAPKKLEYDSGSLKMEPGTSKWRRERPESC 795

  Fly  1338 NNNNSGGGAKMDGSPHHRPGS-RNGRDNWSKMPEPL--------------NGQKVEKSD---KSS 1384
            ::::.||..|...|..| ||| :.|:.....:..|:              .|:..:|..   |::
Human   796 DDSSKGGELKKPISLGH-PGSLKKGKTPPVAVTSPITHTAQSALKVAGKPEGKATDKGKLAVKNT 859

  Fly  1385 PSRRSMGGGGSGSSSKQGSPSSSSRTKGVPPSFGYVK--RANGSIASTAEQQNIAMMMAAGGAG- 1446
            ..:||....|....|....|.|.........||||.|  .|.|:          |.:|..||:.
Human   860 GLQRSSSDAGRDRLSDAKKPPSGIARPSTSGSFGYKKPPPATGT----------ATVMQTGGSAT 914

  Fly  1447 ------ANGLPC----GRTAHVSAVPRTASGRKVAGGTQTLPNDMNKLPPNTQHRSFSLTGPTAT 1501
                  ::|:|.    ||...:. |..:|....:|.|.::          |.|:|  ||..| |.
Human   915 LSKIQKSSGIPVKPVNGRKTSLD-VSNSAEPGFLAPGARS----------NIQYR--SLPRP-AK 965

  Fly  1502 QLSQSIRERLATGSHSLPKPGSDLHVFQHRISNRGGTRHDGSLSD--------------TQTYAE 1552
            ..|.|:     ||....|:|.|. .:....:|.:.|......|.:              .||..|
Human   966 SSSMSV-----TGGRGGPRPVSS-SIDPSLLSTKQGGLTPSRLKEPTKVASGRTTPAPVNQTDRE 1024

  Fly  1553 VKPEYSSYAMWLKHSNTAGSRLSDGESVEQLQIGSPALTR------------------------- 1592
             |.:..:.|:.|...|.:...:...||..:.|...|..|:
Human  1025 -KEKAKAKAVALDSDNISLKSIGSPESTPKNQASHPTATKLAELPPTPLRATAKSFVKPPSLANL 1088

  Fly  1593 -----------------HGHKM--IH---NRSGGP------GQMAGQMSGNESPYVQSPRMNRSN 1629
                             |..|:  :|   :.||||      ...|..::.|.:.:.|...:....
Human  1089 DKVNSNSLDLPSSSDTTHASKVPDLHATSSASGGPLPSCFTPSPAPILNINSASFSQGLELMSGF 1153

  Fly  1630 SIRSTKSEKMYPSMMSRAGEVE-IEPYYCLP---VGTNGVLTAQMAAAMAAQSQAAQ----GNPG 1686
            |:  .|..:|||.:......:| ::....||   ..:..|.|.....|...:.:..:    |:|.
Human  1154 SV--PKETRMYPKLSGLHRSMESLQMPMSLPSAFPSSTPVPTPPAPPAAPTEEETEELTWSGSPR 1216

  Fly  1687 VGV---------------------------------NVGGVAWSQPTS--PTPLTRGPFNTAAG- 1715
            .|.                                 .:||:..|...|  |:|.......:|.|
Human  1217 AGQLDSNQRDRNTLPKKGLRYQLQSQEETKERRHSHTIGGLPESDDQSELPSPPALPMSLSAKGQ 1281

  Fly  1716 -ASVLSPTHGTT------------SAAGLVGPGGGAGGGAMVGHRLTYPK----------KNDEV 1757
             .:::|||..||            .||..:..|...|....:..|   ||          ..|:|
Human  1282 LTNIVSPTAATTPRITRSNSIPTHEAAFELYSGSQMGSTLSLAER---PKGMIRSGSFRDPTDDV 1343

  Fly  1758 HGSAASLLSGGSSLYGNAEER-QAHEIRRLKRELQDARDQVLSLSSQLSTNAHVVTAFEQSLSNM 1821
            |||..||.|..||.|.:|||| |:.:||:|:|||:.::::|.:|:||||.||::|.||||||.||
Human  1344 HGSVLSLASSASSTYSSAEERMQSEQIRKLRRELESSQEKVATLTSQLSANANLVAAFEQSLVNM 1408

  Fly  1822 TNRLHQLTATAERKDGELTDMRQTIELLRKQSIQAGLTTAHMQSMGVQTQGQGQVQGQALGQALG 1886
            |:||..|..|||.||.||.|:|:||:.|:|::.:|                |..:||
Human  1409 TSRLRHLAETAEEKDTELLDLRETIDFLKKKNSEA----------------QAVIQG-------- 1449

  Fly  1887 QPGSDQKPPNSGSQRAINANNGS-MPLGMQRQHSTDSMCSLNSISSGCSAAQDKN---KANKKKG 1947
                           |:||:..: ..|.::||:|:||:.|||||:|..|....|:   |..|||.
Human  1450 ---------------ALNASETTPKELRIKRQNSSDSISSLNSITSHSSIGSSKDADAKKKKKKS 1499

  Fly  1948 W---LRSSFTKAFSRNAKISKTSRHVGHHHHHNHSQ-QELA--------SGKLPLHNGHGEPLGL 2000
            |   |||||.||||    |.|     |.....::|. :|:|        |.||.    ||
Human  1500 WVYELRSSFNKAFS----IKK-----GPKSASSYSDIEEIATPDSSAPSSPKLQ----HG----- 1546

  Fly  2001 ASLATQPAPPLPNSKQSSPAKTVTLIDNAKP------IDAIDQE--DQHVVEDLKKQLREKDLVL 2057
               :|:.|.|...|..||...|......|.|      ..|.::|  ::..|.:|:.:|.||::.|
Human  1547 ---STETASPSIKSSTSSSVGTDVTEGPAHPAPHTRLFHANEEEEPEKKEVSELRSELWEKEMKL 1608

  Fly  2058 TDIRLEALSSASQLESLKEMMNKMRAEMMSLKHNNERLQKLVTTRSLAGSEASLGQAISPNGSVA 2122
            ||||||||:||.||:.|:|.|:.|:.|:..||..|:||:  |.....:||        :| |.|.
Human  1609 TDIRLEALNSAHQLDQLRETMHNMQLEVDLLKAENDRLK--VAPGPSSGS--------TP-GQVP 1662

  Fly  2123 GSSEVS---RRYSLADSNSRPPMELPARLSEELELEEDCLPPAPAPEQPPPPAPNGVSVAPLSPS 2184
            |||.:|   |...||.::|..|           .|.:..|.|.           :|:|..  .|.
Human  1663 GSSALSSPRRSLGLALTHSFGP-----------SLADTDLSPM-----------DGISTC--GPK 1703

  Fly  2185 THVDLTPPPPALEAAPMASPVHMASATEELADVCDGKKIAIACYLGQPEAFAKYCEELQELDGFY 2249
            ..|       .|.......|.|:.
Human  1704 EEV-------TLRVVVRMPPQHII----------------------------------------- 1720

  Fly  2250 ANGHEADSQSQSERKSNYTSASCNEFVIACTYISGKTTWQNLDYVVRKTFKDYVARIDPGTNLGL 2314
                :.|.:.|             ||.:.|:.:|||..|:.||..|.:.||||::::||.:.|||
Human  1721 ----KGDLKQQ-------------EFFLGCSKVSGKVDWKMLDEAVFQVFKDYISKMDPASTLGL 1768

  Fly  2315 NTDSITSYHLGEAKRGPEMGFPELLPCGYIVGSVRTLYICLQG-----VGSLAFDSLIPRSIVHR 2374
            :|:||..|.:...||..:...||:.||.   ..|..:.:.|:|     |.||.|::|||:.::..
Human  1769 STESIHGYSISHVKRVLDAEPPEMPPCR---RGVNNISVSLKGLKEKCVDSLVFETLIPKPMMQH 1830

  Fly  2375 YISLLTEHRRLILCGPSGTGKSYLARRLAEFLVARSARGNPSEAIATFNVDHKSSKDLRQYLGHI 2439
            |||||.:||||:|.|||||||:||..||||:||.||.|......::|||:..:|.|||:.||.::
Human  1831 YISLLLKHRRLVLSGPSGTGKTYLTNRLAEYLVERSGREVTEGIVSTFNMHQQSCKDLQLYLSNL 1895

  Fly  2440 AEQAAIANGVSELPSVIILDNLHHASALGDVFSCLLSAGPANKLPCIIGTMSQATCNTTNLQLHH 2504
            |.|.....|:.::|.||:||:|..|.::.::.:..|:. ..:|.|.||||.:|....|.|..||.
Human  1896 ANQIDRETGIGDVPLVILLDDLSEAGSISELVNGALTC-KYHKCPYIIGTTNQPVKMTPNHGLHL 1959

  Fly  2505 NFRWVLTANHMEPVKGFLGRFLRRRLFQLELQTQHPQPELAAVLAWLPSVWQHINRFLEVHSSSD 2569
            :||.:..:|::||..|||.|:|||:|.:.:......:.||..||.|:|.:|.|::.|||.||:||
Human  1960 SFRMLTFSNNVEPANGFLVRYLRRKLVESDSDINANKEELLRVLDWVPKLWYHLHTFLEKHSTSD 2024

  Fly  2570 VTIGPRLFLACPMDLKDSQVWFTDIWNYHLSPYLVEAVREGVQLYGRRGGAWNDPSAFIRNSYPW 2634
            ..|||..||:||:.::|.:.||.|:||..:.|||.|..::|::::|:: .||.||..::|::.||
Human  2025 FLIGPCFFLSCPIGIEDFRTWFIDLWNNSIIPYLQEGAKDGIKVHGQK-AAWEDPVEWVRDTLPW 2088

  Fly  2635 PYGPDSVPPLRQINAEDVGLEGVALTNGDQ-----------QDPLLNMLMRLQEAANYSEAQDQE 2688
            |........|..:....||...:|....|:           .|||:.||::|||||||.|:.|:|
Human  2089 PSAQQDQSKLYHLPPPTVGPHSIASPPEDRTVKDSTPSSLDSDPLMAMLLKLQEAANYIESPDRE 2153

  Fly  2689 SDCASLDSNV 2698
            :   .||.|:
Human  2154 T---ILDPNL 2160

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sick	NP_001260606.1	CH	535..637	CDD:214479
		AAA	2382..2531	CDD:214640	66/148 (45%)
		AAA_22	2385..2476	CDD:290137	39/90 (43%)
NAV1	NP_001376546.1	PHA03378	<31..240	CDD:223065	44/225 (20%)
		SMC_prok_B	<1366..>1450	CDD:274008	45/122 (37%)
		AAA	1837..1948	CDD:214640	49/111 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	401	1.000	Domainoid score	I735
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	861	1.000	Inparanoid score	I432
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001074
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_103597
Panther	1	1.100	-	-	O	PTHR12784
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X908
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	7.050