DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sick and NAV3

DIOPT Version :9

Sequence 1:NP_001260606.1 Gene:sick / 35277 FlyBaseID:FBgn0263873 Length:2707 Species:Drosophila melanogaster
Sequence 2:NP_001019554.1 Gene:NAV3 / 89795 HGNCID:15998 Length:2385 Species:Homo sapiens


Alignment Length:2679 Identity:757/2679 - (28%)
Similarity:1107/2679 - (41%) Gaps:764/2679 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   468 PTESNYVLFNPGPVPSRHVQYKIRKPRPLSTHSDADSGFLSPCSPEEMRANPAILVLQQCD---- 528
            |..:...:.|.|...|:|.     ..|||.. ::.:|..|| |.         :.:...|:    
Human    19 PVHTALPIPNLGTTGSQHC-----SSRPLEL-TETESSMLS-CQ---------LALKSTCEFGEK 67

  Fly   529 -SVQGY------MEIYTDWANYYLERAKSKRKVTDLSADCRDGLLLAEVIEAVTSFKVPDLVKKP 586
             .:||.      .:|||||||:||.::..||.:.||..|..||:||||:|:.:.:.||.|:...|
Human    68 KPLQGKAKEKEDSKIYTDWANHYLAKSGHKRLIKDLQQDIADGVLLAEIIQIIANEKVEDINGCP 132

  Fly   587 KNQQQMFDNVNSCLHVLRSQSVGGLENITTNDICAGRLKAVLALFFALSRFKQQAKQTKSIGVGC 651
            ::|.||.:||:.||..|.::.| .::.::..:|..|.|||:|.|||:|||:|||....:..    
Human   133 RSQSQMIENVDVCLSFLAARGV-NVQGLSAEEIRNGNLKAILGLFFSLSRYKQQQHHQQQY---- 192

  Fly   652 GGGVGGSSSTLTGSGSVLGIGIGGLRTPGSSLNQDKNQQEQQQQQQQQQTPQQLAQSLENGNEMV 716
                  ..|.:.....|..      .:|.|..:|.|.||:.|.....:...|      .|.:.:.
Human   193 ------YQSLVELQQRVTH------ASPPSEASQAKTQQDMQSSLAARYATQ------SNHSGIA 239

  Fly   717 NRQIAPAYAKVNGGTAIPLPATVMVQRRCPPDKVRPLPPTPNHTPSIPG---LGKSGSDFNTSRP 778
            ..|..|        |.:|.|:.|               |....:..:.|   |.:....||:...
Human   240 TSQKKP--------TRLPGPSRV---------------PAAGSSSKVQGASNLNRRSQSFNSIDK 281

  Fly   779 NSPPT--------SNHTIQSLKSGNNNSLRPPSI-----KSGIPSPS------------------ 812
            |.||.        |:...|| .||.|.:::|||.     .|.|||||                  
Human   282 NKPPNYANGNEKDSSKGPQS-SSGVNGNVQPPSTAGQPPASAIPSPSASKPWRSKSMNVKHSATS 345

  Fly   813 ------------SP---------------QTAPQ-KHSMLDKLKLFNKEKQQNAVNAASVASKTQ 849
                        ||               :|||. :.|||:|.||         |||.:.....|
Human   346 TMLTVKQSSTATSPTPSSDRLKPPVSEGVKTAPSGQKSMLEKFKL---------VNARTALRPPQ 401

  Fly   850 IQSKRTSSSSGFSSARSERSDS---SLSLNDGHGS---------QLKPP---SISVSSQKP--QP 897
            ..|...|.......|.||..:.   :..||.| ||         :|.||   |.::|::|.  ||
Human   402 PPSSGPSDGGKDDDAFSESGEMEGFNSGLNSG-GSTNSSPKVSPKLAPPKAGSKNLSNKKSLLQP 465

  Fly   898 KTKQ------SKLLAAQQKKEQANKATKLDKKEKSPARSLNKEESGNESRSSTMGRTGKSSLVRA 956
            |.|:      :|:...:..||:.::.|::..|:.|...||..:.|     .:|..:  |.||:.:
Human   466 KEKEEKNRDKNKVCTEKPVKEEKDQVTEMAPKKTSKIASLIPKGS-----KTTAAK--KESLIPS 523

  Fly   957 VGGVEK------NTPKTSSKSSLHSKSDSK---------SSLKAPQLLQSPSSGGLPKPIAAIKG 1006
            ..|:.|      ...:|.|..|..||...|         .||..|..::..|:...|.|:...:.
Human   524 SSGIPKPGSKVPTVKQTISPGSTASKESEKFRTTKGSPSQSLSKPITMEKASASSCPAPLEGREA 588

  Fly  1007 TSKLP--------------SLGGGAGHLPAAESQQNQQLLKRETSDISSNISQPPPAEPPISTHA 1057
            ....|              |.|.||..||     |.||.....|:.::           |....|
Human   589 GQASPSGSCTMTVAQSSGQSTGNGAVQLP-----QQQQHSHPNTATVA-----------PFIYRA 637

  Fly  1058 HIHQNQTPPPPYYANSQPTSHISSHGFLSEPSTPQHSSGIYGSSRLPPPKSALSAPRKLEYNAG- 1121
            |.....|..|...:.:.||....|:...::....:.|.....:.|:...|:.....:.||.... 
Human   638 HSENEGTALPSADSCTSPTKMDLSYSKTAKQCLEEISGEDPETRRMRTVKNIADLRQNLEETMSS 702

  Fly  1122 ----------------------------PHILSSP---THHQRQGLPRPLVNSAPNT----PTAS 1151
                                        |::.|.|   |....|..||.....||:.    |.:.
Human   703 LRGTQISHSTLETTFDSTVTTEVNGRTIPNLTSRPTPMTWRLGQACPRLQAGDAPSLGAGYPRSG 767

  Fly  1152 PNKF-HTIPSKIVGTIYESKEEQLLPAPPPASGGSSILPMRPLLR------GYNSHVTLPTRGAR 1209
            .::| ||.||:.:.|                         .||.|      |..|.:.:..:.: 
Human   768 TSRFIHTDPSRFMYT-------------------------TPLRRAAVSRLGNMSQIDMSEKAS- 806

  Fly  1210 GGHHPHQSYLDF-CESDIGQGYCSDGDALRVGSSPGGSRFHDIDNGYLSEGSSGLN--------- 1264
                   |.||. .|.|:| ||.||||.|  |.|   .|..||::||:::|  |||         
Human   807 -------SDLDMSSEVDVG-GYMSDGDIL--GKS---LRTDDINSGYMTDG--GLNLYTRSLNRI 856

  Fly  1265 -------------------------GPSSSAGGISPGKHFLSM------------------MRAR 1286
                                     ..||.:.|:|.....:|.                  .|..
Human   857 PDTATSRDIIQRGVHDVTVDADSWDDSSSVSSGLSDTLDNISTDDLNTTSSVSSYSNITVPSRKN 921

  Fly  1287 TQLPTTIEER------------IRNSRGSLDSIGTAANG----SSAASQASSSGG--STTTHAQN 1333
            |||.|..|:|            ::......||.|.|...    ||...:.....|  ::.:.:|.
Human   922 TQLRTDSEKRSTTDETWDSPEELKKPEEDFDSHGDAGGKWKTVSSGLPEDPEKAGQKASLSVSQT 986

  Fly  1334 NNNNNNNNSGGGA----KMDGSPHHRPGSRNGRDNWSKMPEPLNGQKVEKSDKSSPSRRSMGGGG 1394
            .:.....::.|||    |...|....||..:......|...||.|..:::    |||......|.
Human   987 GSWRRGMSAQGGAPSRQKAGTSALKTPGKTDDAKASEKGKAPLKGSSLQR----SPSDAGKSSGD 1047

  Fly  1395 SGSSSKQGSPSSSSRTKGVPPSFGYVKRANGSIASTAEQQNIAMMMAAGGAGANGLPCGRTAHVS 1459
            .|.....|...|::.:     |||: |:.:|..:|       ||:.::|....:|     :|.:.
Human  1048 EGKKPPSGIGRSTATS-----SFGF-KKPSGVGSS-------AMITSSGATITSG-----SATLG 1094

  Fly  1460 AVPRTAS--GRKVAGGTQTLPNDMNK----------------------------LPPNTQHRS-- 1492
            .:|::|:  |:..||...:|....|:                            :|....|||  
Human  1095 KIPKSAAIGGKSNAGRKTSLDGSQNQDDVVLHVSSKTTLQYRSLPRPSKSSTSGIPGRGGHRSST 1159

  Fly  1493 ----FSLTGPTATQLSQSIRERLATGS-HSLPKP--GSDLHVFQHRISNRGGTRHDGSLSDTQTY 1550
                .:::..:|...:..:||....|| .|.|..  .:|....:..:|:.......||...:.|.
Human  1160 SSIDSNVSSKSAGATTSKLREPTKIGSGRSSPVTVNQTDKEKEKVAVSDSESVSLSGSPKSSPTS 1224

  Fly  1551 AEV------------KPEYSSYAMWLKHSNTAGSRLSDGESVEQLQ----IGSPALTRHGHKMIH 1599
            |..            .|:.:|..........||.:.:...:.|.::    :.||:.|......:.
Human  1225 ASACGAQGLRQPGSKYPDIASPTFRRLFGAKAGGKSASAPNTEGVKSSSVMPSPSTTLARQGSLE 1289

  Fly  1600 NRSGGPGQM--AGQMSGNESPYVQSP-------------------------------RMNRSNSI 1631
            :.|.|.|.|  ||.:||:.||....|                               ..|.|:|.
Human  1290 SPSSGTGSMGSAGGLSGSSSPLFNKPSDLTTDVISLSHSLASSPASVHSFTSGGLVWAANMSSSS 1354

  Fly  1632 RSTKSEKMYPSMMS-RAGEVEIEPYYCLPVGTNGVLTAQMAAAMAAQS----------------- 1678
            ..:|....|.||.| ......|:    ||:..:|.|:.........||                 
Human  1355 AGSKDTPSYQSMTSLHTSSESID----LPLSHHGSLSGLTTGTHEVQSLLMRTGSVRSTLSESMQ 1415

  Fly  1679 ---------------QAAQGNPGVGV------NVGGVAWSQPTSPTPLTRGPFNTAAG----ASV 1718
                           .:.|.|...|.      :.||:..:...||........::|||    :::
Human  1416 LDRNTLPKKGLRYTPSSRQANQEEGKEWLRSHSTGGLQDTGNQSPLVSPSAMSSSAAGKYHFSNL 1480

  Fly  1719 LSPTHGTTSAAGLVGPG-----------------------GGAGG----GAMVGHRLTYPKKNDE 1756
            :|||:  .|...|.||.                       |.|..    ...:.|..::....:|
Human  1481 VSPTN--LSQFNLPGPSMMRSNSIPAQDSSFDLYDDSQLCGSATSLEERPRAISHSGSFRDSMEE 1543

  Fly  1757 VHGSAASLLSGGSSLYGNAEERQAH--EIRRLKRELQDARDQVLSLSSQLSTNAHVVTAFEQSLS 1819
            ||||:.||:|..||||..|||: ||  :|.:|:|||..::::|.:|:||||.|||:|.|||:||.
Human  1544 VHGSSLSLVSSTSSLYSTAEEK-AHSEQIHKLRRELVASQEKVATLTSQLSANAHLVAAFEKSLG 1607

  Fly  1820 NMTNRLHQLTATAERKDGELTDMRQTIELLRKQSIQAGLTTAHMQSMGVQTQGQGQVQGQALGQA 1884
            |||.||..||.|||:|:.||.::|:|||:|:.|:..|                |..:||     |
Human  1608 NMTGRLQSLTMTAEQKESELIELRETIEMLKAQNSAA----------------QAAIQG-----A 1651

  Fly  1885 LGQPGSDQKPPNSGSQRAINANNGSMPLGMQRQHSTDSMCSLNSISSGCSAAQDK---NKANKKK 1946
            |..|   ..||..              |.::||||::|:.|:||.:|..|.....   :|..|||
Human  1652 LNGP---DHPPKD--------------LRIRRQHSSESVSSINSATSHSSIGSGNDADSKKKKKK 1699

  Fly  1947 GW-------LRSSFTKAFSRNAKISKTSRHVGHHHHHNHSQQEL------ASGKLPLHNGHGEPL 1998
            .|       |||||.:||.:.......|.|        ...:||      ||.||| ||. |: .
Human  1700 NWVNSRGSELRSSFKQAFGKKKSTKPPSSH--------SDIEELTDSSLPASPKLP-HNA-GD-C 1753

  Fly  1999 GLASL---ATQPAPPL---PNSKQSSPAKTVTLIDNAKPIDAIDQEDQHVVEDLKKQLREKDLVL 2057
            |.||:   .:..|.||   |..:|:.|    .:..:...|....:.:..::..||.:||||:|.|
Human  1754 GSASMKPSQSASASPLVWPPKKRQNGP----VIYKHRSRICECTEAEAEIILQLKSELREKELKL 1814

  Fly  2058 TDIRLEALSSASQLESLKEMMNKMRAEMMSLKHNNERLQKLVTTRSLAGSEASLGQAISPNGSVA 2122
            |||||||||||..|:.::|.||:|:.|:..||..|:||            :|..|....|....:
Human  1815 TDIRLEALSSAHHLDQIREAMNRMQNEIEILKAENDRL------------KAETGNTAKPTRPPS 1867

  Fly  2123 GSSEVSRRYSLADSNSRPPMELPARLSEELELEEDCLPPAPAPEQPPPPAPNGVSVAPLSPSTHV 2187
            .||.     |.:.|:||..:                                |:|:      .::
Human  1868 ESSS-----STSSSSSRQSL--------------------------------GLSL------NNL 1889

  Fly  2188 DLTPPPPALEAAPMASPVHMASATEELADVCDGKKIAIACYLGQPEAFAKYCEELQELDGFYANG 2252
            ::|      ||  ::|.:.:..|.:..... ||:.:.|...:.:               |:   |
Human  1890 NIT------EA--VSSDILLDDAGDATGHK-DGRSVKIIVSISK---------------GY---G 1927

  Fly  2253 HEADSQSQSERKSNYTSASCNEFVIACTYISGKTTWQNLDYVVRKTFKDYVARIDPGTNLGLNTD 2317
            ...|.:||:             ::|....:||||.|..||.|:|:.||:||.|||..|:|||::|
Human  1928 RAKDQKSQA-------------YLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRIDTSTSLGLSSD 1979

  Fly  2318 SITSYHLGEAKRGPEMGFPELLPCGYIVGSVRTLYICLQGV-----GSLAFDSLIPRSIVHRYIS 2377
            .|.||.:|:..|...:..||||||||:||....:.:.|:||     .|..||:|||:.|..||.:
Human  1980 CIASYCIGDLIRSHNLEVPELLPCGYLVGDNNIITVNLKGVEENSLDSFVFDTLIPKPITQRYFN 2044

  Fly  2378 LLTEHRRLILCGPSGTGKSYLARRLAEFLVARSARGNPSEAIATFNVDHKSSKDLRQYLGHIAEQ 2442
            ||.||.|:||.|||||||:|||.:|||:::.:|.|....:|||||||||||||:|:|||.::|||
Human  2045 LLMEHHRIILSGPSGTGKTYLANKLAEYVITKSGRKKTEDAIATFNVDHKSSKELQQYLANLAEQ 2109

  Fly  2443 AAIANGVSELPSVIILDNLHHASALGDVFSCLLSAGPANKLPCIIGTMSQATCNTTNLQLHHNFR 2507
            .:..|...|||.|||||||||..:|.|:|:..|:. ..||.|.|||||:|...::.||:||||||
Human  2110 CSADNNGVELPVVIILDNLHHVGSLSDIFNGFLNC-KYNKCPYIIGTMNQGVSSSPNLELHHNFR 2173

  Fly  2508 WVLTANHMEPVKGFLGRFLRRRLFQLELQTQHPQPELAAVLAWLPSVWQHINRFLEVHSSSDVTI 2572
            |||.|||.|||||||||:|||:|.::|::......:|..::.|:|..|.|:|.|||.||||||||
Human  2174 WVLCANHTEPVKGFLGRYLRRKLIEIEIERNIRNNDLVKIIDWIPKTWHHLNSFLETHSSSDVTI 2238

  Fly  2573 GPRLFLACPMDLKDSQVWFTDIWNYHLSPYLVEAVREGVQLYGRRGGAWNDPSAFIRNSYPWPYG 2637
            ||||||.||||::.|:|||.|:|||.|.||::||||||:|:||:| ..|.|||.::.::|||...
Human  2239 GPRLFLPCPMDVEGSRVWFMDLWNYSLVPYILEAVREGLQMYGKR-TPWEDPSKWVLDTYPWSSA 2302

  Fly  2638 --PDSVPPLRQINAEDVGLEGVALT-----------NGDQQDPLLNMLMRLQEAANYSEAQDQES 2689
              |...|.|.|:..||||.|....|           ...:.|||:||||:||||||||..|..:|
Human  2303 TLPQESPALLQLRPEDVGYESCTSTKEATTSKHIPQTDTEGDPLMNMLMKLQEAANYSSTQSCDS 2367

  Fly  2690 DCAS-----LDSNV 2698
            :..|     |||::
Human  2368 ESTSHHEDILDSSL 2381

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sickNP_001260606.1 CH 535..637 CDD:214479 45/101 (45%)
AAA 2382..2531 CDD:214640 91/148 (61%)
AAA_22 2385..2476 CDD:290137 53/90 (59%)
NAV3NP_001019554.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 17..38 5/23 (22%)
CH 81..182 CDD:237981 45/101 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 203..625 111/479 (23%)
EssA <468..545 CDD:299614 18/83 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 877..1312 91/456 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1351..1370 7/18 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1410..1468 7/57 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1650..1778 48/160 (30%)
PRKG1_interact 1794..1857 CDD:292521 31/74 (42%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1850..1881 11/47 (23%)
P-loop_NTPase 2036..>2066 CDD:304359 18/29 (62%)
AAA 2049..2169 CDD:214640 67/120 (56%)
AAA 2052..>2132 CDD:99707 50/79 (63%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2360..2385 7/22 (32%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 401 1.000 Domainoid score I735
eggNOG 1 0.900 - - E1_2CMAI
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 861 1.000 Inparanoid score I432
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001074
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_103597
Panther 1 1.100 - - LDO PTHR12784
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3248
SonicParanoid 1 1.000 - - X908
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.980

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