Protein Alignment sick and Nav2

DIOPT Version :10

• Sequence 1: NP_001260606.1
• Gene: sick / 35277
• FlyBaseID: FBgn0263873
• Length: 2707
• Species: Drosophila melanogaster
• Sequence 2: XP_006541374.1
• Gene: Nav2 / 78286
• MGIID: 2183691
• Length: 2489
• Species: Mus musculus
• Alignment Length: 2731
• Identity: 792/2731 - (29%)
• Similarity: 1149/2731 - (42%)
• Gaps: 814/2731 - (29%)

  Fly   480 PVPSRHVQYKIRKPRPLSTHSDADSGFLSPCSPEEMRANPAILVLQQCDSVQGYMEIYTDWANYY 544
            |:.|:.:|....:..||...|..::||                     |:     :|||||||:|
Mouse    57 PLKSQGLQEPTGEGLPLLKSSSLENGF---------------------DT-----QIYTDWANHY 95

  Fly   545 LERAKSKRKVTDLSADCRDGLLLAEVIEAVTSFKVPDLVKKPKNQQQMFDNVNSCLHVLRSQSVG 609
            |.::..||.:.||..|..||:|||::|:.|.:.|:.|:...|||:.||.:|:::||:.|.::.:
Mouse    96 LAKSGHKRLIKDLQQDVTDGVLLAQIIQVVANDKIEDINGCPKNRSQMIENIDACLNFLAAKGI- 159

  Fly   610 GLENITTNDICAGRLKAVLALFFALSRFKQQAKQTKS------IGVGCGGGVGGSSSTLTGSGS- 667
            ..:.::..:|..|.|||:|.|||:|||:|||.:|.:.      :          |||.|..:||
Mouse   160 NTQGLSAEEIRNGNLKAILGLFFSLSRYKQQQQQQQQQPEKQPL----------SSSPLPPAGSQ 214

  Fly   668 VLGIGI---------GGLRTPGS--------SLNQDKNQQEQQQQQQQQQTPQQLAQSLENGNEM 715
            |.|...         .||.||.:        |..|.|.|.|.|.....:.:.|........|.:.
Mouse   215 VAGAPSQCQAGTPQHQGLATPQAPCQLLQPVSHQQGKTQVEMQSSASSKDSSQSKIIRFTLGQKK 279

  Fly   716 VNRQIAP--------AYAKVNGGTAIPLPATVMVQRRCPP----DKVRPL----PPTP--NH--- 759
            ::|...|        :.||..||:|      ....||...    ||.:|:    ||.|  ||
Mouse   280 ISRLPGPTARVAAAGSEAKTRGGSA------AANNRRSQSFNNYDKSKPVTSPPPPAPPSNHEKE 338

  Fly   760 -----TPSIPGLGKSGSDFNTSRP--NSP-----------PTSNHTIQSLKSGNNN--------- 797
                 ..|.||:.:     |...|  |||           |..:.|.:..:|.:.:
Mouse   339 PLASSASSHPGMSE-----NVPAPLENSPSVPVNCSSSAIPQPSMTSKPWRSKSLSVKHTATSAM 398

  Fly   798 -SLRPPSIKSGIPSPSSPQTAP-QKHSMLDKLKLFNKEKQQNAVNAAS-----------VASKTQ 849
             |::|...::..|:|.:.:.|| .:.|||:||||||.:....|...::           :.|..:
Mouse   399 LSVKPAGPEAPRPTPEAMKPAPNNQKSMLEKLKLFNSKGGSKAGEGSASRDTSCERLEILPSFEE 463

  Fly   850 IQSKRTSSSSGFSSARSERSDSSLSLNDGHGSQLKPPSISVSSQKPQPKTKQSKLLAAQQKKEQA 914
            .:....:::...|:.....|...::|.   |...:..|.:::::|..||..:.:....|::||:
Mouse   464 TEELEATANRALSTVGPASSSPKIALK---GIAQRTFSRALTNKKSSPKGNEKEKEKQQREKEK- 524

  Fly   915 NKATKLDKKEKSPARSLNKEESGNESRSSTMGRTGKSSLVRA-VGGVE-KNTPKTSSK-SSLHSK 976
                   :|||...:.|.|       |.|...|.......:| :.||. ...||.||| :|...|
Mouse   525 -------EKEKEKGKDLTK-------RVSVTDRPDLKEETKADLSGVAVTEMPKKSSKIASFIPK 575

  Fly   977 SDSKSSLKAPQLLQSPSSGGLPKP----IAAIKGTSKLPSLGG--GAGHLPAAESQQNQQLLKRE 1035
            ....:|.|  :...:||..|:|||    ::|...::.:|...|  ..|.|.:....|..||..|.
Mouse   576 GGKLNSTK--KEATAPSHSGIPKPGMKNVSAKSPSAPIPPKEGERSRGKLSSGLPPQKAQLDSRH 638

  Fly  1036 TSDISSNISQP------PPAEPPISTHA--------------------------HIHQNQTPPPP 1068
            :|..||..|..      ....|.||:..                          :.|.|.....|
Mouse   639 SSSSSSLASSEGKGPGGTSLNPSISSQTVSGSVGTTQTTGSNTVSVQLPQPQQQYNHPNTATVAP 703

  Fly  1069 YYANSQP------TSHISSHGFLSEPS----------------TPQHSSGIYGSSRLPPPKSALS 1111
            :...||.      |:..||.|...|||                .|:       :.||...|:...
Mouse   704 FLYRSQTDTEGNVTAESSSAGVSMEPSHYTKSGQPALEELTAEDPE-------ARRLRTVKNIAD 761

  Fly  1112 APRKLEYN--------------------------AGPHILS---SPT---HHQRQGLPRPLVNSA 1144
            ..:.||..                          :|..|||   .||   ....|..||.....|
Mouse   762 LRQNLEETMSSLRGTQVTHSTLETTFDTNVTTEISGRSILSLTGRPTPLSWRLGQSSPRLQAGDA 826

  Fly  1145 PN-----TPTASPNKFHTIPSKIVGTIYESKEEQLLPAPPPASGGSSILPMRPLLRGYNSHVTLP 1204
            |:     .|.|:.::|  |.::....:|.:...:.|     ||.||||.
Mouse   827 PSMGNGYPPRANASRF--ISAEAGRYVYSAPLRRQL-----ASRGSSIC---------------- 868

  Fly  1205 TRGARGGHHPHQSYLDFCESDI--------GQGYCSDGDALRVGSSPGGSRFHDIDNGYLSEGSS 1261
                      |....|..:.|:        ..||.||||.|     ....|..||.:||:::|..
Mouse   869 ----------HVDVSDKADDDVDLEGISMDAPGYMSDGDVL-----SKNIRSDDITSGYMTDGGL 918

  Fly  1262 GLNGPSSSAGGISPGKHFLSMMRARTQLPTT------------------IEERIRNSRGSLDSIG 1308
            ||.  :.....:..|   ::::|...|..|:                  |.:.|.|.  |.|.|.
Mouse   919 GLY--TRRLNRLPDG---MAVVRETLQRNTSLGLGDADSWDDSSSVSSGISDTIDNL--STDDIN 976

  Fly  1309 TAANGSSAASQASSSGGS------TTTHAQNNNNN---------NNNNSGGGAKMDGSPHHRPGS 1358
            |:::.||.|:..:||..:      ...|:|...|:         ::..|..|.||:      |||
Mouse   977 TSSSISSYANTPASSRRNLDVQTDAEKHSQVERNSLWSGDDIKKSDGGSDSGVKME------PGS 1035

  Fly  1359 R----------------NGRDN--------WSK---------MPE------------PLNG---- 1374
            :                :|:.|        |.:         ||.            |..|
Mouse  1036 KWRRNPSDMSDESDKSVSGKKNPVLSQTGSWRRGMTAEVGITMPRTKPSAPTGTLKTPGTGKTDD 1100

  Fly  1375 ----QKVEKSDKSSPSRRSMGGGG--SGSSSKQGSPSSSSRTKGV-PPSFGYVKRANGSIASTAE 1432
                :|...|.|:|..:||....|  ||..||:..| |||||..| ..|||: |:.:||.|..|
Mouse  1101 AKVSEKGRLSPKASQVKRSPSDAGRSSGDESKKTLP-SSSRTPTVNANSFGF-KKQSGSAAGLA- 1162

  Fly  1433 QQNIAMMMAAGGAGANGLPCGRTAHVSAVPRTA------SGRKVAGGTQTLPN-DMNKLP----P 1486
                  |:.|.||...    .|:|.:..:|:::      :|||.:  ....|| |...|.    .
Mouse  1163 ------MITASGATVT----SRSATLGKIPKSSALVGRPTGRKTS--MDGAPNQDDGYLSLSSRT 1215

  Fly  1487 NTQHRSF-------SLTGPTATQLSQSIRERLATGSHSLPKP----------GSDLHVFQHRISN 1534
            |.|:||.       |..|......:.||...:::.|..||.|          ||.|....::...
Mouse  1216 NLQYRSLPRPSKSNSRNGAGNRCSTSSIDSNMSSKSAGLPVPKLREPSKASLGSSLPGLVNQTDK 1280

  Fly  1535 RGGTRHD----GSLSDTQTYAEVKPEYSSYAMWL----KHSNTAG---SRLSDGESVEQLQ---- 1584
            ..|...|    .|.:..:.....:|..||....|    |:::.|.   .||..|:..:.:.
Mouse  1281 EKGISSDSESVASCNSVKVNPATQPVSSSAQATLQPGTKYADVASPTLRRLFGGKPTKPIATAET 1345

  Fly  1585 ------IGSP--ALTRHGHKMIHNRSGGPGQMAGQMSG--------NESPYVQSP---RMNRSNS 1630
                  |.:|  .||:.|:  :.:.||.....:|..|.        |:||...||   ....|||
Mouse  1346 MKSAVVISNPHATLTQQGN--LESPSGSGVLSSGSSSPLYSKNVDLNQSPLASSPSSAHSGPSNS 1408

  Fly  1631 ------------------------------------------------IRSTKSEKMYPSMMSRA 1647
                                                            :.|||.:.:.|.:.:.:
Mouse  1409 LTWGTSSSAVSKDGLGFQSVSSLHTSCESIDISLGSGGGLSHNSSPGPVASTKEDSLMPFVRTSS 1473

  Fly  1648 GEVEI----------EPYYC------------------LP-VGTNGVLTAQMAAAMAA----QSQ 1679
            .:..:          .|.:|                  || .|.....|:|:.....|    :|.
Mouse  1474 VKTTLSESPLSSPAASPKFCRSTLPRKQDSDPHLDRNTLPKKGLRYTPTSQLRTQEDAKEWFRSH 1538

  Fly  1680 AAQGNPGVGVNVGGVAWSQPTSPTPLTRGPFNTAAGASVLSP----------THGTTSAAGLVGP 1734
            :|.|......|....:.|..|||:. ||..|:..|..:.::.          ||..::|.|...|
Mouse  1539 SAGGLQDTATNSPFSSGSSVTSPSG-TRFNFSQLASPTAVTQMSLSNPTMLRTHSLSNADGQYDP 1602

  Fly  1735 -----------------------GGGAGG-----------GAMV---------GHRLTYPKKNDE 1756
                                   |....|           |..|         .|.|..|.:...
Mouse  1603 YTDSRFRNSSMSLDEKSRTMSRSGSFRDGFEEELWKESSTGCFVSYLHNSLHFSHPLLLPLRLPT 1667

  Fly  1757 VHGSAASLLSGGSSLYGNAEERQAHEIRRLKRELQDARDQVLSLSSQLSTNAHVVTAFEQSLSNM 1821
            ||||:.||:|..||:|...||:...|||:|:|||..::::|.:|::||:.|||:|.||||||.||
Mouse  1668 VHGSSLSLVSSTSSIYSTPEEKCQSEIRKLRRELDASQEKVSALTTQLTANAHLVAAFEQSLGNM 1732

  Fly  1822 TNRLHQLTATAERKDGELTDMRQTIELLRKQSIQAGLTTAHMQSMGVQTQGQGQVQGQALGQALG 1886
            |.||..||.|||:||.||.::|:|||||:||:..|                |..:.|     .:.
Mouse  1733 TIRLQSLTMTAEQKDSELNELRKTIELLKKQNAAA----------------QAAING-----VIN 1776

  Fly  1887 QPGSDQKPPNSGSQRAINANNGSMPLGMQRQHSTDSMCSLNSISSGCSAA---QDKNKANKKKGW 1948
            .|..:.|  .:||.:|.:       |.::||||:||:.|:||.:|..|..   :..:|..|:|.|
Mouse  1777 TPELNCK--GNGSAQATD-------LRIRRQHSSDSVSSINSATSHSSVGSNIESDSKKKKRKNW 1832

  Fly  1949 ---LRSSFTKAFSRNAKISKTSRHVGHHHHHNHSQQELASGKLPLHNGHGEPLGLASLATQPAPP 2010
               |||||.:||.:.......|.|.......:.|..  :|.||| |||          :|...|.
Mouse  1833 VNELRSSFKQAFGKKKSPKSASSHSDIEEMTDSSLP--SSPKLP-HNG----------STGSTPL 1884

  Fly  2011 LPNSKQSSPAKTVTLIDNAKPIDAIDQEDQHVVEDLKKQLREKDLVLTDIRLEALSSASQLESLK 2075
            |.|:..:|      ||.     :.:|.|.:.|:: |:.:||:|::.||||||||||||.||:.|:
Mouse  1885 LRNAHSNS------LIS-----ECMDSEAETVMQ-LRNELRDKEMKLTDIRLEALSSAHQLDQLR 1937

  Fly  2076 EMMNKMRAEMMSLKHNNERLQKLVTTRSLAGSEASLGQAISPNGSVAGSSEVSRRYSLADSNSRP 2140
            |.||:|::|:..||..|:||:          ||:      ..:|.....|:||
Mouse  1938 EAMNRMQSEIEKLKAENDRLK----------SES------QGSGCSRAPSQVS------------ 1974

  Fly  2141 PMELPARLSEELELEEDCLPPAPAPEQPPPPAPNGVSVAPLSPSTHVDLTPPPPALEAAPMASPV 2205
               :.|...:.|.|.:..|                    .|:.||.:|:           :....
Mouse  1975 ---ISASPRQSLGLSQHSL--------------------NLTESTSLDM-----------LLDDT 2005

  Fly  2206 HMASATEELADVCDGKKIAIACYLGQPEAFAKYCEELQELDGFYANGHEADSQSQSERKSNYTSA 2270
            ...||.:|     .|:.:.|.                       .:..||....:..|.
Mouse  2006 GECSARKE-----GGRHVKIV-----------------------VSFQEAMKWKEDSRP------ 2036

  Fly  2271 SCNEFVIACTYISGKTTWQNLDYVVRKTFKDYVARIDPGTNLGLNTDSITSYHLGEAKRGPEMGF 2335
              :.|:|.|..:||||.|..||.|||:.||:|:..:||.:.|||::||:..|.:||.||......
Mouse  2037 --HLFLIGCIGVSGKTKWDVLDGVVRRLFKEYIVHVDPVSQLGLSSDSVLGYSIGEIKRSNASET 2099

  Fly  2336 PELLPCGYIVGSVRTLYICLQG-----VGSLAFDSLIPRSIVHRYISLLTEHRRLILCGPSGTGK 2395
            ||||||||:||...|:.:.::|     :.||.|:||||:.|:.||:||||||||:||.|||||||
Mouse  2100 PELLPCGYLVGENTTILVTVKGLTENSLDSLVFESLIPKPILQRYVSLLTEHRRIILSGPSGTGK 2164

  Fly  2396 SYLARRLAEFLVARSARGNPSEAIATFNVDHKSSKDLRQYLGHIAEQAAIANGVSELPSVIILDN 2460
            :|||.||:|::|.|..|......||||||||||||:|||||.::|:|....|...::|.||||||
Mouse  2165 TYLANRLSEYVVLREGRELTDGVIATFNVDHKSSKELRQYLSNLADQCNSENNAVDMPLVIILDN 2229

  Fly  2461 LHHASALGDVFSCLLSAGPANKLPCIIGTMSQATCNTTNLQLHHNFRWVLTANHMEPVKGFLGRF 2525
            |||.|:||::|:.||:. ..:|.|.|||||:|||.:|.||||||||||||.|||.||||||||||
Mouse  2230 LHHVSSLGEIFNGLLNC-KYHKCPYIIGTMNQATSSTPNLQLHHNFRWVLCANHTEPVKGFLGRF 2293

  Fly  2526 LRRRLFQLELQTQHPQPELAAVLAWLPSVWQHINRFLEVHSSSDVTIGPRLFLACPMDLKDSQVW 2590
            |||:|.:.|:..:....||..::.|:|.||.|:|||||.||||||||||||||:||:|:..|:||
Mouse  2294 LRRKLMETEISGRVRNAELVKIINWIPKVWHHLNRFLEAHSSSDVTIGPRLFLSCPIDVDGSRVW 2358

  Fly  2591 FTDIWNYHLSPYLVEAVREGVQLYGRRGGAWNDPSAFIRNSYPWPYGPD--SVPPLRQINAEDVG 2653
            |||:|||.:.|||:||||||:|||||| ..|.||:.::.::|||...|.  ..|||.|:..||||
Mouse  2359 FTDLWNYSIIPYLLEAVREGLQLYGRR-APWEDPAKWVMDTYPWAASPQQHEWPPLLQLRPEDVG 2422

  Fly  2654 LEGVAL--------------TNGDQQDPLLNMLMRLQEAANYSEAQDQESDCAS-------LDSN 2697
            .:|.:|              |.|   |||:|||||||||||||..|..:||..|       |||:
Mouse  2423 FDGYSLPREGSTSKQVPPSDTEG---DPLMNMLMRLQEAANYSSPQSYDSDSNSNSHHDDILDSS 2484

  Fly  2698 V 2698
            :
Mouse  2485 L 2485

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sick	NP_001260606.1	CH_NAV2-like	535..638	CDD:409061	44/102 (43%)
		PHA03247	<729..1182	CDD:223021	129/605 (21%)
		Atrophin-1	<985..>1182	CDD:460830	57/293 (19%)
		McrB	<2368..2597	CDD:441011	143/228 (63%)
Nav2	XP_006541374.1	CH_NAV2	74..188	CDD:409134	48/140 (34%)
		Herpes_BLLF1	<333..727	CDD:282904	92/418 (22%)
		PHA03307	975..>1326	CDD:223039	88/371 (24%)
		Mplasa_alph_rch	<1688..>1960	CDD:275316	124/336 (37%)
		COG4372	1688..>1764	CDD:443500	43/75 (57%)
		COG4372	<1907..>1962	CDD:443500	31/71 (44%)
		McrB	<2137..2374	CDD:441011	148/237 (62%)