DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sick and nav2

DIOPT Version :9

Sequence 1:	NP_001260606.1	Gene:	sick / 35277	FlyBaseID:	FBgn0263873	Length:	2707	Species:	Drosophila melanogaster
Sequence 2:	XP_031755997.1	Gene:	nav2 / 733744	XenbaseID:	XB-GENE-1008034	Length:	2407	Species:	Xenopus tropicalis

Alignment Length:	2708	Identity:	771/2708 - (28%)
Similarity:	1117/2708 - (41%)	Gaps:	795/2708 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   481 VPSRHVQYKIRKPRPLSTHSDAD------SGFLSPC----------------SPEEMRANPAI-- 521
            :||..|..|::...|...||.|.      .....||                |...::..||.
Frog     1 MPSILVASKMKSGLPKPIHSAAPILHVPARTIPQPCYIKLGNRAEVSKHAFPSQTPLKPQPAYDS 65

  Fly   522 -----LVLQQCDSVQGY-MEIYTDWANYYLERAKSKRKVTDLSADCRDGLLLAEVIEAVTSFKVP 580
                 |:::...:..|: .:|||||||:||.::..||.:.||..|..||:||||:|:.|.:.|:.
Frog    66 SGDGHLIMKSHSTEGGFDTQIYTDWANHYLAKSGHKRLIKDLQQDVTDGVLLAEIIQVVANEKIE 130

  Fly   581 DLVKKPKNQQQMFDNVNSCLHVLRSQSVGGLENITTNDICAGRLKAVLALFFALSRFKQQAKQTK 645
            |:...|||:.||.:|:::||..|.::.: .::.:::.:|..|.|||:|.|||:|||:|||..|.:
Frog   131 DINGCPKNRSQMIENIDTCLSFLAAKGI-NIQGLSSEEIRNGNLKAILGLFFSLSRYKQQQSQKQ 194

  Fly   646 SIGVGCGGGVGGSSSTLTGSGSVLGIGIGGLRTPGSSLNQDKNQQEQQ---------QQQQQQQT 701
            .                            ....|...|.|..:....|         ||.||...
Frog   195 P----------------------------QQYQPAPQLYQPPSTPHAQPHPAAPLQCQQPQQPPH 231

  Fly   702 PQQLAQS------------------LENGNEMVNRQIAPAYAKVNGGTAIPLPATVMVQRRCPP- 747
            ||..||:                  ...|....:|..||:...:..||...........||...
Frog   232 PQTKAQADMHSSSSSKGPSDIKILRFSLGQRKQSRLPAPSARAMAAGTENKSRGQTGGSRRSQSF 296

  Fly   748 ---DKVRPL--PPT-----PNHTPSIPGLGKSGSDFNT-SRPNSPPTSNHTIQSLKSGNNNSLRP 801
               :|.:||  |.|     |...|.....|.|.:.|.| ..|..||..|.:.....:..|...|.
Frog   297 NNHEKAKPLNSPATVNDKGPAENPVSQQSGMSENGFPTLCNPGVPPCPNSSAIPQPNSTNKPWRS 361

  Fly   802 P-------------SIKSGIPS-PSSPQTAPQ-----KHSMLDKLKLFNKEKQQNAVNAASVASK 847
            .             |:|...|. |..|...|:     :.|||:||||||.:    .|:.|:..|.
Frog   362 KSLSAKHTATSSILSVKQAAPDCPKQPTEPPKPAPNNQKSMLEKLKLFNSK----GVSKAAGTSP 422

  Fly   848 TQIQSKRTSSSSGFSSARSERSDSSLSLNDGHGSQLKPPSISVSSQKPQPKTK---QSKLLAAQQ 909
            .....:|..|...|..|    .:..::..:|:.:.|       :|..|:...|   |..|..|..
Frog   423 EGTSCERLDSIPSFEGA----EEMDVATRNGNNANL-------ASNSPKIALKGIAQRTLGRALT 476

  Fly   910 KKEQANKATKLDK---KEKSPARSLNKEESGNESRSSTMGRTGKSSLVRAVGGVEKNTPKTSSK- 970
            .|:.:.|..:.:|   |||...:..:|..|..|::...     :.....|.|.:    ||.|||
Frog   477 NKKSSPKGAEKEKDKQKEKEKTKEASKRVSVTETKEEP-----RDEQTAAAGEI----PKKSSKI 532

  Fly   971 SSLHSKSDSKSSLKAPQLLQSPSSGGLPKPIAAIKGTSKLPSLGGGAGHLPAAESQQNQ------ 1029
            :|...|.....:.|....:..|.| |:|||  .||.|.     |..:...||.|.::::
Frog   533 ASFIPKGGKLGNAKKEASVPPPHS-GIPKP--GIKNTP-----GKASSAPPAKEGERSRKSGSGL 589

  Fly  1030 -----QLLKRETSDISSNISQ--------PPPAEPPISTHA--------------------HIHQ 1061
                 ||..|.:|..||..|.        |...:|...||.                    :.|.
Frog   590 SLHKAQLDNRHSSSSSSLASSEGKGGGCAPAGGQPGSGTHGPLQSTGSGTVSVQLPQPQQQYTHP 654

  Fly  1062 NQTPPPPYYANSQ--PTSHIS---SHGFLSEPSTPQHSSG------IYG----SSRLPPPKSALS 1111
            |.....|:...||  |...:|   |.|.::..|...:.:|      :.|    :.||...|:...
Frog   655 NTATVAPFMYRSQADPEGGVSVETSSGGINMDSALYNKTGPPCLEDLSGEDPETRRLRTVKNIAD 719

  Fly  1112 APRKLEYN----AGPHILSS----------PTHHQRQGL------PRPLV----NSAPNTPTASP 1152
            ..:.||..    .|..|..|          .|....:|:      |.||.    .|:|......
Frog   720 LRQNLEETMSSLRGTQITHSTLETTFDSNVTTEISGRGILGLTARPTPLSWRLGQSSPRLQAGD- 783

  Fly  1153 NKFHTIPSKIVGTIYESKEEQLLPAPPPASGGSSILPMRPLLRGYNSHVTLPTR---GARGGHHP 1214
                 .||  :|..|           ||.:..|..:...|....|::    |.|   .:|||:..
Frog   784 -----APS--LGNGY-----------PPRANASRFINCEPGRYVYSA----PLRKQLASRGGNIG 826

  Fly  1215 HQSY---------LDFCESDIGQGYCSDGDALRVGSSPGGSRFHDIDNGYLSEGSSGL------N 1264
            |...         ::....|.| ||.||||.|     ....|..||.:||:::|..||      .
Frog   827 HMDVSDKGGDVMDIEGVSIDAG-GYMSDGDVL-----SKNIRSDDITSGYMTDGGLGLYTRRLNR 885

  Fly  1265 GPSSSAG-------GISPGKHFLSMMRARTQLPTTIEERIRNSRGSLDSIGTAANGSSAASQASS 1322
            .|...|.       ..|.|:.........:.:.:.|.:.|.|.  |.|.|.|:::.||.|:..:|
Frog   886 LPDGMAAVRETLQRNASAGQGDADSWDDSSSVSSGISDTIDNL--STDDINTSSSISSYANTPAS 948

  Fly  1323 SGGS------TTTHAQNNNNN---------NNNNSGGGAKMDGSPHHRPGSRNGRDNWSKMPEPL 1372
            |..:      |..|...:.|:         ::..|..|.|||.      ||:     |.|.|..|
Frog   949 SRKNLDVQTDTEKHLHIDRNSLWSGDEVKRSDGGSDSGMKMDS------GSK-----WRKNPSDL 1002

  Fly  1373 NGQKVEKSDKSS------------------------------PSRRSMGGGGSG-----SSSKQG 1402
            :    ::||||:                              ||...:...|:|     .:|::|
Frog  1003 S----DESDKSTSGRKTTVISQTGSWRRGMTAQVGITAPRTKPSAAGLKAPGTGKTDDAKASEKG 1063

  Fly  1403 -----------SPSSSSRTKG----VPP---------SFGYVKRANGSIASTAEQQNIAMMMAAG 1443
                       |||.:.|:.|    .||         :||: |:..|::.      .|.::.|:|
Frog  1064 RLSPKAAHIKRSPSDAGRSSGDEAKKPPNTSRAIPTNTFGF-KKQGGTVV------GIPIVTASG 1121

  Fly  1444 GAGANGLPCGRTAHVSAVPRTA-----SGRKV-AGGTQTLPNDMNKL--PPNTQHRSF-----SL 1495
            ....:|     :|.:..:|:::     |.||. |.|:|...:...::  ..|.|:||.     |.
Frog  1122 ATITSG-----SATLGKMPKSSGLIGRSNRKANADGSQNQDDGYLQINSRTNLQYRSLPRPSKSR 1181

  Fly  1496 TGPTATQLSQSIRERLATGSHSLP-----KPGSDLHVFQHRISN--RGGTRHDGSLSDTQTYA-- 1551
            :|......:.||...:::.|..||     :||.  ....|.:..  ....:..|..||.::.|
Frog  1182 SGTGNRSSTSSIDSNISSKSAGLPIPKLREPGK--VTLGHSVPGLVNQTDKEKGISSDNESVASC 1244

  Fly  1552 -EVKPEYSSYAMWLKHSNTAGSRLSDGESVEQLQIGSPALTR----------------------H 1593
             .:|...:|.|.      ..|||...|....  .:.||.|.|                      :
Frog  1245 NSIKMTPASQAA------CNGSRQQQGNKYP--DVSSPTLRRLFGGKPNKSLTTENMKNSMVISN 1301

  Fly  1594 GHKMIHNRSG--GPGQMAGQMSGNESP-YVQ----SPRMNRSNSIRSTKSEKM-------YPSMM 1644
            .|..:::::.  .|...|...||..|| ||:    ||..:...|..|..|..:       ..|.:
Frog  1302 PHATMNSQANPDSPSGSAILSSGGSSPLYVKSMDHSPLASSPGSAHSAPSNSLTWGTTASSSSAV 1366

  Fly  1645 SRAGEVEIEPYY--C----LPVGTN---GVLTAQ-----MA------AAMAAQSQAAQGNPGVGV 1689
            |:.|...:...:  |    :.:.:|   |.|||.     ||      :.....|::...:||...
Frog  1367 SKEGFQSVSSLHTSCESIDISLSSNNSPGALTASSREDTMAPFVRTNSIKTTLSESPLSSPGASP 1431

  Fly  1690 ----------------------------------------------------------NVGGV-- 1694
                                                                      :.||:
Frog  1432 KFSRNTLPRKQDSSYLLSHRCRSDLCLDRNTLPKKGLRCAPSCQIRSQDEAKEWLRSHSSGGLQD 1496

  Fly  1695 -AWSQPTSPTPLTRGPFNTAAGASVLSPTHGTT-------------SAAGLVGPGGGAGGGAMVG 1745
             |.:.|.||......|..|....|.|:...||:             |.:...|.|...|......
Frog  1497 TANNSPFSPGASITSPSGTRFNFSQLASPTGTSQMCLSNQTMLRAHSLSNADGCGDPYGESRFRN 1561

  Fly  1746 HRLTYPKKN-------------DEVHGSAASLLSGGSSLYGNAEERQAHEIRRLKRELQDARDQV 1797
            ..::..:|:             :|||||:.||:|..||:|...||:...|||:|:|||..::::|
Frog  1562 SSMSLDEKSRTMSRSGSFRDGFEEVHGSSLSLVSSTSSVYSTPEEKCQSEIRKLRRELDASQEKV 1626

  Fly  1798 LSLSSQLSTNAHVVTAFEQSLSNMTNRLHQLTATAERKDGELTDMRQTIELLRKQSIQAGLTTAH 1862
            .:|::|||.|||:|.||||||||||.||..||.:||:||.||.::|:||::|:||:..|
Frog  1627 SALTTQLSANAHLVAAFEQSLSNMTIRLQSLTMSAEQKDSELNELRKTIDMLKKQNAAA------ 1685

  Fly  1863 MQSMGVQTQGQGQVQGQALGQALGQPGSDQKPPNSGSQRAINANNGSMPLGMQRQHSTDSMCSLN 1927
                  |....|.:....||...|. |:.| ||:               |.::||||:||:.|:|
Frog  1686 ------QAAINGVINTPELGCKAGN-GTSQ-PPD---------------LRIRRQHSSDSVSSIN 1727

  Fly  1928 SISSGCSAAQD---KNKANKKKGW---LRSSFTKAFSRNAKISKTSRHVGHHHHHNHSQQELASG 1986
            |.:|..|...:   .:|..|:|.|   |||||.:||.:.......|.|.......:.|..  :|.
Frog  1728 SATSHSSVGSNVDSDSKKKKRKNWVNELRSSFKQAFGKKKSPKSASSHSDIEEMTDSSLP--SSP 1790

  Fly  1987 KLPLHNGHGEPLGLASLATQPAPPLPNSKQSSPAKTVTLIDNAKPIDAIDQEDQHVVEDLKKQLR 2051
            ||| |||       ::|:|   |.|..|..||.....|           :.|.:.|:: |:.:||
Frog  1791 KLP-HNG-------SALST---PRLRGSHSSSLISEFT-----------ENEAESVMQ-LRNELR 1832

  Fly  2052 EKDLVLTDIRLEALSSASQLESLKEMMNKMRAEMMSLKHNNERLQ-----KLVTTRSLAGSEASL 2111
            :|::.||||||||||||.||:.|:|.||:|::|:..||..|:||:     |...|:    |:.||
Frog  1833 DKEMKLTDIRLEALSSAHQLDQLRESMNRMQSEIEKLKSENDRLKAENNGKCSRTQ----SQVSL 1893

  Fly  2112 GQAISPNGSVAGSSEVSRRYSLADSNSRPPM-----------------ELPARLSEELELEEDCL 2159
             .:.||..|: |.|::|  .||.:|:|...:                 .:...||||::..||..
Frog  1894 -SSCSPRQSM-GPSQLS--LSLTESSSLDMLLDDAAADGTMRKESRHVRIVVNLSEEMKWREDAR 1954

  Fly  2160 PPAPAPEQPPPPAPNGVSVAPLSPSTHVDLTPPPPALEAAPMASPVHMASATEELADVCDGKKIA 2224
            |
Frog  1955 P---------------------------------------------------------------- 1955

  Fly  2225 IACYLGQPEAFAKYCEELQELDGFYANGHEADSQSQSERKSNYTSASCNEFVIACTYISGKTTWQ 2289
                                                            ..|:|.|..:.|||.|.
Frog  1956 ------------------------------------------------RLFLIGCIGVGGKTKWD 1972

  Fly  2290 NLDYVVRKTFKDYVARIDPGTNLGLNTDSITSYHLGEAKRGPEMGFPELLPCGYIVGSVRTLYIC 2354
            .||.||::.||:|:..:||.|.||||:||:..|.:|:.||......||||||||:||...|:.:.
Frog  1973 VLDGVVKRLFKEYIIHVDPVTQLGLNSDSVLGYSIGDIKRVGNAETPELLPCGYLVGENNTICVT 2037

  Fly  2355 LQGVGS-----LAFDSLIPRSIVHRYISLLTEHRRLILCGPSGTGKSYLARRLAEFLVARSARGN 2414
            ::|:..     |.|::|.|:.|:.||||||.||||:||.|||||||:|||.||||:||....|..
Frog  2038 VRGLAQSSLDCLVFETLTPKPILQRYISLLMEHRRIILSGPSGTGKTYLANRLAEYLVQWEGREL 2102

  Fly  2415 PSEAIATFNVDHKSSKDLRQYLGHIAEQAAIANGVSELPSVIILDNLHHASALGDVFSCLLSAGP 2479
            ....||||||||||||:|||||.::|:|.:..|..::.|.|||||||||..:||::|:.||:. .
Frog  2103 AEGVIATFNVDHKSSKELRQYLSNLADQCSNENSSADTPLVIILDNLHHVGSLGEIFNGLLNC-K 2166

  Fly  2480 ANKLPCIIGTMSQATCNTTNLQLHHNFRWVLTANHMEPVKGFLGRFLRRRLFQLELQTQHPQPEL 2544
            ..|.|.|||||:|||.:|.||||||||||||.|||.|||||||||:|||:|.:.|:.::...|||
Frog  2167 YQKCPYIIGTMNQATSSTPNLQLHHNFRWVLCANHTEPVKGFLGRYLRRKLIETEINSRTRNPEL 2231

  Fly  2545 AAVLAWLPSVWQHINRFLEVHSSSDVTIGPRLFLACPMDLKDSQVWFTDIWNYHLSPYLVEAVRE 2609
            ..::.|:|.||||:|:|||.||||||||||||||:||:|:..|:|||||:|||.:.|||:|||||
Frog  2232 VKIIDWIPKVWQHLNKFLETHSSSDVTIGPRLFLSCPIDVDGSRVWFTDLWNYSIIPYLLEAVRE 2296

  Fly  2610 GVQLYGRRGGAWNDPSAFIRNSYPWPYGPD--SVPPLRQINAEDVGLEGVAL----TNGDQQ--- 2665
            |:|||||| ..|.||:.::..:|||...|.  ..|||.|:..||||.:|.::    |:..|.
Frog  2297 GLQLYGRR-APWEDPARWVMETYPWTAVPQQHEWPPLLQLRPEDVGFDGYSVPREGTSSKQAAPS 2360

  Fly  2666 ----DPLLNMLMRLQEAANYSEAQDQESDCAS------LDSNV 2698
                |||:|||||||||||||..|..:||..|      ||:::
Frog  2361 DAEGDPLMNMLMRLQEAANYSSPQSYDSDSNSNSHQDDLDTSL 2403

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sick	NP_001260606.1	CH	535..637	CDD:214479	44/101 (44%)
		AAA	2382..2531	CDD:214640	95/148 (64%)
		AAA_22	2385..2476	CDD:290137	53/90 (59%)
nav2	XP_031755997.1	CH_NAV2	73..187	CDD:409134	46/114 (40%)
nav2	XP_031755997.1	AAA_22	2067..>2152	CDD:379165	53/84 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	300	1.000	Domainoid score	I1411
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	689	1.000	Inparanoid score	I682
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001074
OrthoInspector	1	1.000	-	-		otm48342
Panther	1	1.100	-	-	O	PTHR12784
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X908
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.150