DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sick and nav3

DIOPT Version :9

Sequence 1:NP_001260606.1 Gene:sick / 35277 FlyBaseID:FBgn0263873 Length:2707 Species:Drosophila melanogaster
Sequence 2:XP_021330780.1 Gene:nav3 / 567779 ZFINID:ZDB-GENE-021205-1 Length:2418 Species:Danio rerio


Alignment Length:2757 Identity:757/2757 - (27%)
Similarity:1110/2757 - (40%) Gaps:882/2757 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly   481 VPSRHVQYKIRKP----RPLST--------HSDADSGFLSPCSPE-------------------- 513
            :|...|..|:|:|    ||:.|        .|....| |:|.|.|                    
Zfish     1 MPVVGVASKLRQPAVGSRPIHTALPIPNLGRSSMAHG-LAPRSSELRVTESPMLSCQLSFKTEIH 64

  Fly   514 EMRAN----PAILVLQQCDSVQ--GYMEIYTDWANYYLERAKSKRKVTDLSADCRDGLLLAEVIE 572
            :.|.|    ||..:.:.....:  ...:|||||||:||.::...|.:.||:.|..||:||||:|:
Zfish    65 DRRTNLVPAPAATLARSSREAEESKICKIYTDWANHYLAKSGCPRLIKDLTQDIPDGVLLAEIIQ 129

  Fly   573 AVTSFKVPDLVKKPKNQQQMFDNVNSCLHVLRSQSVGGLENITTNDICAGRLKAVLALFFALSRF 637
            .:.:.|:.|:...||:..||.:||..||..|.::.| .::.::..::|.|.||::|.|||.|||:
Zfish   130 IIANEKIEDINSCPKSHSQMIENVECCLSFLGARGV-SVQGLSAEEVCNGNLKSILGLFFILSRY 193

  Fly   638 KQQ-----------------------------------------AKQTKSIGVGCGGGVGG---S 658
            |||                                         |:.|...|   ..|:..   .
Zfish   194 KQQQQHQQQYLQSLVELQQHVTHQTTGAAQLSQHKTQDMQSSLTARYTSPPG---HSGIAAPQKK 255

  Fly   659 SSTLTGSGSVLGIGIGGLRTPGSSLNQDKNQQEQQQQQQQQQTPQQLAQSLENGNEMVNRQIAPA 723
            ::.|.|...|...|.|...:.|||   :.|::.|......:..|.|.|    :||:.        
Zfish   256 NTRLPGPSRVPAAGSGSNSSKGSS---NLNRRSQSFNSIDKSKPLQYA----SGNDR-------- 305

  Fly   724 YAKVNGGTAIPLPATVMVQRRCPPDKVRPLPPTPNHTPSIPGLGKSGSDFNTSRPNSPPTSNHTI 788
             ..|.|   ||||.::                  |.:.|:|. ..||....::.|:  ||:..|.
Zfish   306 -ESVKG---IPLPGSM------------------NGSGSVPS-STSGQQLASAIPS--PTAGKTW 345

  Fly   789 QS----LKSGNNNSL---RPPSIKSGIPSPSS-----------PQTAP-QKHSMLDKLKLFN-KE 833
            :|    :|....:|:   :|||..|....|||           .::|| .:.|||:|.::.| :.
Zfish   346 RSKSMNMKHSATSSMLATKPPSPTSSPTPPSSSDRLRPPITDASKSAPGNQRSMLEKFRILNPRA 410

  Fly   834 KQQNAVNAASVASKTQIQSKRTSSSSGFSSARSERSDSSLSLNDG--HGSQLKPPSISVSSQK-- 894
            ..:.:.:.|.:|    :|.:...|..|.....|......:|...|  ..|...|||.|.:.:.  
Zfish   411 TSRTSPSVAEMA----LQEEDDLSEFGDEGTFSPTPPCGISKQQGKPSASAFAPPSKSNNCKNHN 471

  Fly   895 ----PQPKTKQSK--------------LLAAQQKKEQANKATKLDKKEKSPARSLNKEES----- 936
                ||||.|:.|              .:..:..|:.:..|:.:.|..|:.|.|:.||.:     
Zfish   472 NKSLPQPKDKEDKNKTKNKASTPPKEEPVIVETSKKGSKIASLIPKGSKTSAASVKKESAIPASS 536

  Fly   937 -----GNESRSSTMGRTGKSSLVRAVGGVEKNTPKTSSKSSLHSKSDSKSSLKAPQLLQSPSSGG 996
                 |.::.::|....|..|.|.|..|.||......|:|....:|......:...::.|.|:..
Zfish   537 SIPKPGLKAPTATSKPAGTQSCVPATTGGEKTKLNKGSQSIYMQRSLGGLENRKTSMVLSTSTSA 601

  Fly   997 LPKPIAAIKGTSKLPSLGGGA--GHLPAAESQQNQQLLKRETSDISSNISQPPPAEPPISTHAHI 1059
            |        ..|....||||.  |...|.:..|.||                           |.
Zfish   602 L--------SASTTSGLGGGCALGGNGAVQLPQQQQ---------------------------HN 631

  Fly  1060 HQNQTPPPPY----YANSQPTSHISSHGFLSEPSTPQHSSGIYGSS----------------RLP 1104
            |.|.....|:    |:.:..|:.:.     .||........:||.:                |:.
Zfish   632 HPNTATVAPFMYRTYSENDCTTVVP-----PEPCLSPTKELVYGKTAKQCLEEISGEDPETRRMR 691

  Fly  1105 PPKSALSAPRKLEYN----AGPHILSS----------PTHHQRQGLPRPLVNSAPNT----PTAS 1151
            ..|:.....:.||..    .|..|..|          .|....:|||.....|:|.:    ..:|
Zfish   692 TVKNIADLRQNLEETMSSLRGTQITHSTLETTFDTTVTTEVNGRGLPALSSRSSPMSWRLGQGSS 756

  Fly  1152 PN-KFHTIPSKIVGTIYESKEEQLLPAPPPASGGSSIL----PMRPLLRGYNSHVTLPTR----- 1206
            |. :....||.               .||.:|.||:.:    |.|.|       .|.|.|     
Zfish   757 PRLQAGDAPSY---------------TPPRSSAGSTTVRYGEPSRLL-------YTAPLRRAAAS 799

  Fly  1207 GARGGHHPHQSYLDFCESDIG-----QGYCSDGDALRVGSSPGGSRFHDID-NGYLSEG---SSG 1262
            ||||.....:..:    |::|     .||.||||.|       ....|..| :||.::|   |..
Zfish   800 GARGAEPGEKGGI----SEVGPEVDVTGYGSDGDIL-------AKNVHADDISGYHTDGGIYSRN 853

  Fly  1263 LNGPSSSAG---GISPGKHFLSMMRARTQLPTTIEERIRNSRG---SLDSIGT-------AANGS 1314
            ::..|.:.|   .::|.:..:.......|...:.::....|.|   :||:|.|       .:..|
Zfish   854 VDLYSRNVGRPAEMTPAREVVQKGVKEMQGEDSWDDSSSVSSGLSDTLDNISTDDLNPAPYSGIS 918

  Fly  1315 SAASQASSSGGSTTTHAQNNNNNNNNNSGGGAK------------MD------------------ 1349
            |..|:|:.|...|..|.:     .:.:|..||:            ||                  
Zfish   919 SRKSKAAQSNKETHRHIE-----QDASSWAGAEDLKKVDEEMEPGMDPSCKWKTSSPSSSCQGED 978

  Fly  1350 -----GSPHHRPGS---------------RNGRDNWSKMPEPLNGQKVEKSDKSSPSRRSM---- 1390
                 |.|..:.||               ..|.....|.|...:..|..:..|.||...|:    
Zfish   979 ISQKTGLPMSQTGSWRRGMSAQVGITPPRTKGTSTSLKTPGKTDDAKASEKGKGSPKSPSIQRSP 1043

  Fly  1391 --GGGGSGSSSKQGSPSSSSRTKGVPP---SFGYVK---------RANGSIAST----------- 1430
              .|..||...|: .||..:|    ||   ||||.|         .|:|:..::           
Zfish  1044 SDAGKSSGDEGKK-PPSGIAR----PPTTSSFGYKKIPGPAGALITASGATLTSGSATLGKVPKS 1103

  Fly  1431 -------------------AEQQNIAMMMAAGGAGA----NGLP------------CGRTAHVSA 1460
                               |:.|:.|:::..||:..    ..||            ..|:.|.|:
Zfish  1104 ACIGKSTGISNGRKTSLDGAQHQDDAVLLGCGGSEVPLQYRSLPRPAKSSSGGSSVVSRSGHRSS 1168

  Fly  1461 VP--------RTASGRKVAGGTQTLPNDMNKLPPNTQHRSFSLTG---PTATQLSQSIRERLA-- 1512
            ..        ::|.|..||.||          |.:|:.|.....|   .:...::|:.:|::|  
Zfish  1169 SSSIDSNVSGKSAGGSGVAVGT----------PTSTKRRDTGKVGSGRSSPVTINQTDKEKVAGS 1223

  Fly  1513 ----TGSHSLPKPGSDLHVFQHRISNRGGTRHDGSLSDTQTYAEVKPEYSSYAMWLKHSNTAGSR 1573
                ||..:.||...        .|.:.|.|..||     .|    |:.:|........:.|.|:
Zfish  1224 DQEGTGLPTSPKSSP--------TSTQSGLRQPGS-----KY----PDIASPTFRRLFGSKASSK 1271

  Fly  1574 LSD-----------------GESVEQLQIGSPALTRHGHKMIHNRSGGPGQMAGQMSG------- 1614
            .|.                 |....|..:.||:          :.:|..|.|.||..|       
Zfish  1272 PSSPGTPDSGKCPSALGSPHGTLARQASLDSPS----------SGTGSLGSMGGQSGGSSPLYGK 1326

  Fly  1615 ----------------------------------------------------NES-----PYVQS 1622
                                                                :||     |:...
Zfish  1327 TPDLGTDSPASSPASGLSLPSNARPWPPNLSSSSAGSKDTLSCHSMTSLHTSSESIDLPLPHHHG 1391

  Fly  1623 PRMNRSNSIRSTKSEKM-------------YPSMMSRAGEVEIEPYYCLPVGTNGVLTAQMAAAM 1674
            |::.|:.|::||.||.|             ||. .||....|....:.....|.|:         
Zfish  1392 PKVTRTGSVKSTLSEGMPLDRNTLPKKGLRYPP-SSRQTSHEEGKEWLRSHSTGGL--------- 1446

  Fly  1675 AAQSQAAQGNPGVG-VNVGGVAWSQPTSPTPLTRGPFNTAAGASVLSPTHGTTSAAGLVGPGGGA 1738
             ..:.:....||.. .|.|...:|...|||.:::  :|..:.:...|.:.....:..|.|.|...
Zfish  1447 -QDTGSPLSPPGTTCANAGKYHYSNLLSPTSMSQ--YNIPSTSMSRSNSIPAQDSFELYGEGHPL 1508

  Fly  1739 GGGAM--------VGHRLTYPKKNDEVHGSAASLLSGGSSLYG------NAEERQAH-------- 1781
            ||.|.        :....::....||||||:.||:|..||||.      :..|.:||        
Zfish  1509 GGSATSLEERPRGMSRSGSFRDSTDEVHGSSLSLVSSTSSLYSAVLAFLDKTEEKAHSEGQTVQN 1573

  Fly  1782 --EIRRLKRELQDARDQVLSLSSQLSTNAHVVTAFEQSLSNMTNRLHQLTATAERKDGELTDMRQ 1844
              :||:|:|||..::::|.:|:|||:.|||:|.|||:||:|||.||..||.|||:|:.||.::|:
Zfish  1574 TTQIRKLRRELDASQEKVATLTSQLAANAHLVAAFEKSLANMTCRLQSLTMTAEQKESELAELRE 1638

  Fly  1845 TIELLRKQSIQAGLTTAHMQSMGVQTQGQGQVQGQALGQALGQPGSDQKPPNSGSQRAINANNGS 1909
            |||.|:.|:..|            ||         |:..||..|....:                
Zfish  1639 TIEALKTQNTDA------------QT---------AIQVALNGPDHVHR---------------- 1666

  Fly  1910 MPLGMQRQHSTDSMCSLNSISSGCSA-----AQDKNKANKKKGW---------------LRSSFT 1954
            ..|.::||||::||.|:||.:|..|.     |:||.|  |||.|               |||||.
Zfish  1667 ADLRIRRQHSSESMSSINSAASHSSLGSAKDAEDKKK--KKKSWGKDRGHKVADSIPAQLRSSFK 1729

  Fly  1955 KAFSRNAKISKTSRHVGHHHHHNHSQQELASGKLPLHNGHGEP--LGLASLATQPAPPLPNSKQS 2017
            :|||:    .||::....|    ...:|:....||     ..|  |.::..|:.|.|.|     |
Zfish  1730 QAFSK----KKTNKPQSSH----DEIEEMTDSSLP-----SSPKLLHISRQASSPQPLL-----S 1776

  Fly  2018 SPAKTVTLIDNAK--PI--------------------DAIDQEDQHVVEDLKKQLREKDLVLTDI 2060
            ||:.|.....::|  ||                    :..:.|.: ::..||.:||||:|.||||
Zfish  1777 SPSTTEKCFCDSKSSPIWMPKKKSNGHVVYKHRSRLCECTEAEAE-IILQLKNELREKELKLTDI 1840

  Fly  2061 RLEALSSASQLESLKEMMNKMRAEMMSLKHNNERLQKLVTTRSLAGSEASLGQAISPNGSVAGSS 2125
            ||||||||..|:.::|.||:|:.|:..||..|:||:          |..:...|.:|..:....|
Zfish  1841 RLEALSSAHHLDQIREAMNRMQNEIELLKAENDRLK----------SSGNTTPAATPAKTARPPS 1895

  Fly  2126 EVSRRYSLADSNSRPPMELPARLSEELELEEDCLPPAPAPEQPPPPAPNGVSVAPLSPSTHVDLT 2190
            |.|   |.:.|:||..:                                |:|:..|:.:..:   
Zfish  1896 ETS---STSSSSSRQSL--------------------------------GLSLNNLNITDTI--- 1922

  Fly  2191 PPPPALEAAPMASPVHMASATEELADVCDGKKIAIACYLGQPEAFAKYCEELQELDGFYANGHEA 2255
                                   ::|:.                          ||    :|:|.
Zfish  1923 -----------------------MSDIL--------------------------LD----DGYEG 1934

  Fly  2256 D--SQSQSER-------KSNYTSA-SCNEFVIACTYISGKTTWQNLDYVVRKTFKDYVARIDPGT 2310
            :  .:.:|.|       .||.|.| ...:::|....:||||.|..||.|:|:.||:||.|:||.|
Zfish  1935 NLRKEGRSVRIVVTINSDSNKTKAMQKKQYLIGSIGVSGKTKWDVLDGVIRRLFKEYVFRVDPLT 1999

  Fly  2311 NLGLNTDSITSYHLGEAKRGPEMGFPELLPCGYIVGSVRTLYICLQGV--GS---LAFDSLIPRS 2370
            :||:|:|||..|.:|:..|......||||||||:||....:.:.|:||  ||   |.||:|||:.
Zfish  2000 SLGMNSDSIVCYRMGDVVRSHASEVPELLPCGYLVGDNNVITVTLKGVKEGSIDDLVFDTLIPKP 2064

  Fly  2371 IVHRYISLLTEHRRLILCGPSGTGKSYLARRLAEFLVARSARGNPSEAIATFNVDHKSSKDLRQY 2435
            |:.||::||.||||:||.|||||||||||.:||.|:::::.|......:||||||.|||||||||
Zfish  2065 IIQRYLNLLMEHRRIILSGPSGTGKSYLATKLAYFILSKTGREVTDTNLATFNVDQKSSKDLRQY 2129

  Fly  2436 LGHIAEQAAIANGVSELPSVIILDNLHHASALGDVFSCLLSAGPANKLPCIIGTMSQATCNTTNL 2500
            |..:|||........|||:|:|||||||..:|.|:|:..|:. ..:|.|.:||||:|...::.||
Zfish  2130 LSSLAEQCNTEECEIELPTVVILDNLHHIGSLSDIFNGFLNC-KYHKCPYVIGTMNQGVSSSPNL 2193

  Fly  2501 QLHHNFRWVLTANHMEPVKGFLGRFLRRRLFQLELQTQHPQPELAAVLAWLPSVWQHINRFLEVH 2565
            :|||||||||.|||.|||||||||||||:|.:.|:.......:|..::.|:|.:|||:|.|||.|
Zfish  2194 ELHHNFRWVLCANHTEPVKGFLGRFLRRKLIETEIDKNMRSNDLIKIIDWIPKIWQHLNSFLEAH 2258

  Fly  2566 SSSDVTIGPRLFLACPMDLKDSQVWFTDIWNYHLSPYLVEAVREGVQLYGRRGGAWNDPSAFIRN 2630
            |||||||||||||:||||...|:|||||:|||.|.|||:||||||:||||:| .||.|||.::.:
Zfish  2259 SSSDVTIGPRLFLSCPMDADGSRVWFTDLWNYSLVPYLLEAVREGLQLYGKR-AAWEDPSKWVID 2322

  Fly  2631 SYPWPYG--PDSVPPLRQINAEDVGLEGVA----------LTNGDQQ-DPL------LNMLMRLQ 2676
            :|||...  ......|.|:..||||.:|.:          ::..|.: |||      :|||||||
Zfish  2323 TYPWSSASLQHEGQSLLQLRPEDVGYDGYSSSKDGAASKQVSQSDTEGDPLTFRDYKMNMLMRLQ 2387

  Fly  2677 EAANYSEAQDQESDCAS-----LDSNV 2698
            ||||||.||..:||.||     |||::
Zfish  2388 EAANYSSAQSCDSDSASHHEDLLDSSL 2414

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
sickNP_001260606.1 CH 535..637 CDD:214479 42/101 (42%)
AAA 2382..2531 CDD:214640 88/148 (59%)
AAA_22 2385..2476 CDD:290137 50/90 (56%)
nav3XP_021330780.1 CH 92..193 CDD:237981 42/101 (42%)
Herpes_pp85 938..>1097 CDD:332820 33/163 (20%)
Herpes_BLLF1 <1187..>1510 CDD:330317 66/372 (18%)
SH3_and_anchor <1575..>1652 CDD:275056 40/88 (45%)
AAA 2076..2196 CDD:214640 63/120 (53%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 368 1.000 Domainoid score I867
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 780 1.000 Inparanoid score I507
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001074
OrthoInspector 1 1.000 - - otm24695
orthoMCL 1 0.900 - - OOG6_103597
Panther 1 1.100 - - LDO PTHR12784
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3248
SonicParanoid 1 1.000 - - X908
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
99.080

Return to query results.
Submit another query.